Results 91 to 100 of about 15,782,143 (303)
A Mathematical Theory of Co-Design
CoRR, 2015 One of the challenges of modern engineering, and robotics in particular, is designing complex systems, composed of many subsystems, rigorously and with optimality guarantees. This paper introduces a theory of co-design that describes "design problems", defined as tuples of "functionality space", "implementation space", and "resources space", together ...
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Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Design Choices Framework for Co-creation Projects
, 2018 Co-creation has been adopted in many recent design and innovation projects, bringing different stakeholders together and creating a shared understanding and new ideas through creative and participative approaches.
Salmi, Anna +5 more
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管道保护To overcome the limitations of existing gas pipeline leakage location technologies-such as low accuracy, poor adaptability to operating conditions, and insufficient capability to detect micro-leakages-this study proposes a precise leakage location method
Jianchun HU +4 more
doaj +1 more source
Journal of the Audio Engineering Society, 2018 The work of Luca Turchet is supported by a Marie-Curie Individual fellowship of European Union’s Horizon 2020 research and innovation program, under grant agreement No. 749561. Mathieu Barthet also acknowledges support from the EU H2020 Audio Commons grant (688382).
Turchet L, McPherson A, Barthet M
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Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Assessment of the Co-creative Design Process
, 2016 Co-creation in Design is a multi-disciplinary process where co-designers are not only trained professionals from different disciplines, but also members from the community with whom the co-design project is focused.
Spencer, Nicholas +7 more
core +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Discover SustainabilityThe decarbonization and resilience enhancement of building energy systems face critical challenges due to the intermittent nature of solar/wind power and the continuous demand for heat/electricity.
Ying Wang, Xun Dong, Jian Wang
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A behavioral model for co-design [PDF]
, 1999 With chip size reaching one million transistors, the complexity of VLSI algorithms - i.e., algorithms implemented as a digital VLSI circuit - is approaching that of software algorithms - i.e., algorithms implemented as code. However, the design methods for circuits that are commonly found in textbooks resemble the low-level machine language programming
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