Results 151 to 160 of about 2,001,286 (262)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Reducing Stigma in Lung Cancer Screening: Co-Design of a Targeted Resource for Health Professionals in Australia. [PDF]

Health Expect
McFadden K, Harrison NJ, Rose S, Hollinshead G, Rankin NM, Weber M, Dunlop K, Luo D, Nickel B, Houssami N, Dodd RH.   +10 more
europepmc   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

The Co-design of Educational Video Games

, 2022
Daniel Kleffmann, Igor Mayer, Thomas P. Buijtenweg   +2 more
openaire   +2 more sources

Integrating stakeholder perspectives in the co-design of medical device software to monitor Parkinson's disease symptoms- A case-study. [PDF]

MethodsX
Raut RA, Polus B, Ngo QC, Pah ND, Clay-Williams R, Kumar DK.   +5 more
europepmc   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Co-design of a decision aid for the management of lentigo maligna in older and frailer adults. [PDF]

Skin Health Dis
Karponis D, Cardamone E, Mistry K, Halliday F, Patel M, Levell NJ, Stratigos AJ, Nikolaou V, Venables ZC.   +8 more
europepmc   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Co-Design of a Physical Activity Maintenance Intervention for People With Stroke: Protocol for a Mixed Methods Study. [PDF]

JMIR Res Protoc
Pedlow K, McDonough S, Duff N, McConnell K, McFeeters C, Carlin A, Hughes N, Campbell Z, Bell A, Stephenson A, Adamson G, Hawkins J, Howes S.   +12 more
europepmc   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source