Results 161 to 170 of about 2,001,286 (262)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

The community representative council of the National Drug Abuse Treatment Clinical Trials Network: Co-design and early impact. [PDF]

J Subst Use Addict Treat
Moore SK, McLeman B, Saunders EC, Chapman SH, Marsch LA, Ackerson B, Cowan A, Doss DP, Filion S, Fowler R, Fox L, Gary J, Hamilton J, Jones R, Jordan A, Kibben R, Lamont M, Lawdahl T, Martin J, Pee J, Potter J, Peavy M, Ross TB, Scott D, Suarez E, Vest N, Vo H, Rosa C.   +27 more
europepmc   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Co-design and feasibility testing of a midwife-led birth debrief: an implementation science project. [PDF]

BMC Public Health
Buchanan K, Backhouse P, Graham L, O'Meagher A, Bayes S.   +4 more
europepmc   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Assistive Robotics for Healthy Aging: A Foundational Phenomenological Co-Design Exercise. [PDF]

J Med Internet Res
Potter S, Hawley M, Higgins A, Amirabdollahian F, Dragone M, Di Nuovo A, Caleb-Solly P.   +6 more
europepmc   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Creation of EmpowerMe Website to Promote Self-Efficacy in Survivors of Stroke: Co-Design Study. [PDF]

J Med Internet Res
Lynch EA, O'Malley A, Adey-Wakeling Z, Bonevski B, Cadilhac DA, Chamberlain S, Churilov L, Clark R, Cullen R, Godecke E, Harvey G, Jones F, Lannin NA, Larcombe S, Law J, McGrath A, Murphy L, Nesbitt K, Zacharia K, Bidargaddi N, English C.   +20 more
europepmc   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source