Results 191 to 200 of about 2,001,286 (262)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Culturally adapting diabetes self-management education: a community engaged co-design approach. [PDF]

Transl Behav Med
Kansariwala T, Maurer M, Wen MJ, Pickard A, Shiyanbola OO.   +4 more
europepmc   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

A Preventive Social Media Intervention for Perinatal Depression and Anxiety in Regional, Rural, and Remote Communities: Participatory Co-Design Study. [PDF]

J Med Internet Res
Lynch KJ, Shatte ABR, Muller J, George K, Rossini G, Anson A, Hala C, Dimmock J, Hutchinson D, Teague S.   +9 more
europepmc   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Co-Design of strategies to enhance access to Virtual Urgent Care models by equity-deserving populations. [PDF]

PLOS Digit Health
Hitzig SL, Ahmed YHE, Alamgir A, Kupka CF, Ledwos C, Sothilingam R, Alitawi R, Motsenok M, Orr J, Reis L, Siqueira I, Sivakumaran S, Brush T, Devotta K, Haseeb MK, Huynh E, Jalil E, Khorasheh T, Ky K, McLeod SL, MacLellan W, Mills S, Pilested K, Rosenstein D, Sheppard CL, Stothers S, Zhang J, Yoon R, Zhang C, Mehta S, Najeeb U, Hall JN.   +31 more
europepmc   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Maternal Health Literacy among Migrant Women: A Co-Design Study in Portugal. [PDF]

Port J Public Health
Gonçalves E, Dias S, Marques MJ.
europepmc   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Development of a Cystic Fibrosis Weight Management Programme:  protocol for a co-design study. [PDF]

NIHR Open Res
Barrett J, Topping AE, Ntoumanis N, Turner AM, White H, Fenton SAM.   +5 more
europepmc   +1 more source