Results 151 to 160 of about 7,496,605 (313)
Modulation of the immune response to Mycobacterium tuberculosis during malaria/M. tuberculosis co-infection [PDF]
Tuberculosis (TB) causes significant morbidity and mortality on a global scale. The African region has 24% of the world's TB cases. TB overlaps with other infectious diseases such as malaria and HIV, which are also highly prevalent in the African region.
Agbakoba, Nneka R. +7 more
core +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Victoria [cartographic material] /
, 1890 Map of Victoria showing towns, districts, counties and railways with relief shown by hachures.; Plate [4] from: Pearson's Australasian school atlas. Library ed. Melbourne : J.W.
J. W. Pearson & Co.
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Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Victoria [cartographic material]
Map of Victoria showing administrative districts highlighted in different colours.; Plate [2] from: Whitehead's Atlas of Australasia. Melbourne : Published by E.
Whitehead & Co.
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Karte der Inseln des Westlichen Grossen Oceans [cartographic material] /
, 1879 Plate 1 from: [Maps of Oceania by L.Friederichsen & Co., probably published in Mitteilungen der Geographischen Gesellschaft in Hamburg, 1879]. Hamburg : L.
L. Friederichsen & Co.
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Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Karte der Ansiedelungen am Hafen von Apia, Insel Upolo [cartographic material] /
, 1879 Plate 3 from: [Maps of Oceania by L.Friederichsen & Co., probably published in Mitteilungen der Geographischen Gesellschaft in Hamburg, 1879]. Hamburg : L. Friederichsen & Co., 1879.; Map of Apia, Samoa.
L. Friederichsen & Co.
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