Results 1 to 10 of about 32,600 (115)

Metagenomic next-generation sequencing: new horizons in microbiology [PDF]

Frontiers in Cellular and Infection Microbiology
The COVID-19 pandemic has exposed vulnerabilities in global health systems while accelerating the adoption of metagenomic next-generation sequencing (mNGS) as a transformative tool for culture-independent, unbiased microbial detection.
Nan Guo, Nan Guo, Nan Guo, Nan Guo, Shihan Chen, Lina Guo, Xiaotong Qiu, Zhenjun Li, Zhenjun Li   +8 more
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Computed tomography–guided precision biopsy combined with metagenomic next-generation sequencing for etiological diagnosis in patients with blood culture-negative systemic infections [PDF]

Journal of International Medical Research
Objective To evaluate the diagnostic efficacy of computed tomography–guided percutaneous biopsy combined with metagenomic next-generation sequencing in patients with blood culture-negative systemic infections and to assess the clinical impact of using ...
Yongkun Fang, Chenglin Fan, Pingping Liu, Shengping Wang, Wei Zhang   +4 more
doaj   +2 more sources

Metagenomic next-generation sequencing targeted and metagenomic next-generation sequencing for pulmonary infection in HIV-infected and non-HIV-infected individuals

Frontiers in Cellular and Infection Microbiology
BackgroundWhen individuals infected with human immunodeficiency virus (HIV) experience pulmonary infections, they often exhibit severe symptoms and face a grim prognosis.
Luyao Sun, Kaiyu Zhang, Yong Liu, Lihe Che, Peng Zhang, Bin Wang, Na Du   +6 more
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Pathogenic Detection by Metagenomic Next-Generation Sequencing in Osteoarticular Infections

Frontiers in Cellular and Infection Microbiology, 2020
Objectives: To evaluate metagenomic next-generation sequencing (mNGS) as a diagnostic tool in detecting pathogens from osteoarticular infection (OAI) samples.Methods: 130 samples of joint fluid, sonicate fluid, and tissue were prospectively collected ...
Zi-da Huang, Zi-jie Zhang, Bin Yang, Wen-bo Li, Chong-jing Zhang, Xin-yu Fang, Chao-fan Zhang, Wen-ming Zhang, Jian-hua Lin   +8 more
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Clinical impact of metagenomic next-generation sequencing for pathogen identification and guided therapy in pediatric intensive care unit patients with severe pulmonary infections [PDF]

Microbiology Spectrum
To explore the diagnostic efficiency, clinical concordance, and precision treatment value of metagenomic next-generation sequencing (mNGS) for severe pulmonary infections in children in the pediatric intensive care unit (PICU), and to provide evidence ...
Yuping Xu, Ruijuan Ren, Weiqing Liu, Ling Liu, Xinyan Cui, Jia Guo, Shujun Li   +6 more
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Direct detection and identification of periprosthetic joint infection pathogens by metagenomic next-generation sequencing

Scientific Reports, 2023
This study assessed the application of metagenomic next-generation sequencing in pathogen detection of periprosthetic joint infections. A total of 95 cases who previously had undergone hip and knee replacement undergoing revision from January 2018 to ...
Linjie Hao, Pengfei Wen, Wei Song, Binfei Zhang, Yanjie Wu, Yumin Zhang, Tao Ma, Yusheng Qiu   +7 more
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The microbiological diagnostic performance of metagenomic next-generation sequencing in patients with sepsis

BMC Infectious Diseases, 2021
Background In this study, we aimed to perform a comprehensive analysis on the metagenomic next-generation sequencing for the etiological diagnosis of septic patients, and further to establish optimal read values for detecting common pathogens. Methods In
Di Ren, Chao Ren, Renqi Yao, Lin Zhang, Xiaomin Liang, Guiyun Li, Jiaze Wang, Xinke Meng, Jia Liu, Yu Ye, Haoli Li, Sha Wen, Yanhong Chen, Dan Zhou, Xisi He, Xiaohong Li, Kai Lai, Ying Li, Shuiqing Gui   +18 more
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Improving Pulmonary Infection Diagnosis with Metagenomic Next Generation Sequencing

Frontiers in Cellular and Infection Microbiology, 2021
Pulmonary infections are among the most common and important infectious diseases due to their high morbidity and mortality, especially in older and immunocompromised individuals.
Yi-Yi Qian, Hong-Yu Wang, Yang Zhou, Hao-Cheng Zhang, Yi-Min Zhu, Xian Zhou, Yue Ying, Peng Cui, Hong-Long Wu, Hong-Long Wu, Wen-Hong Zhang, Wen-Hong Zhang, Wen-Hong Zhang, Wen-Hong Zhang, Jia-Lin Jin, Jing-Wen Ai   +15 more
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Leishmaniasis Diagnosis via Metagenomic Next-Generation Sequencing

Frontiers in Cellular and Infection Microbiology, 2020
Leishmaniasis is a vector-borne disease caused by Leishmania. Although the incidence of leishmaniasis in China is currently low, it has not been completely eradicated.
Hongbin Chen, Chunhong Fan, Hua Gao, Yuyao Yin, Xiaojuan Wang, Yawei Zhang, Hui Wang   +6 more
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Application of metagenomic next-generation sequencing in cutaneous tuberculosis

Frontiers in Cellular and Infection Microbiology, 2022
Tuberculous infection in a skin wound is a rare but well-known condition. This study describes a child infected with tuberculosis after being wounded. Because of swelling and pain in his wrist tissue, he was admitted to the Affiliated Hospital of Jining ...
Min Kong, Min Kong, Wei Li, Qingsheng Kong, Haixin Dong, Aizhong Han, Liqing Jiang, Liqing Jiang   +7 more
doaj   +1 more source