Frontiers in Cellular and Infection MicrobiologyBackgroundMetagenomic next-generation sequencing (mNGS) technology has been widely used to diagnose various infections. Based on the most common pathogen profiles, targeted mNGS (tNGS) using multiplex PCR has been developed to detect pathogens with ...
Yong Liu +5 more
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Application of Metagenomic Next-Generation Sequencing in Mycobacterium tuberculosis Infection
Frontiers in Medicine, 2022 The fight against Mycobacterium tuberculosis (MTB) has been going on for thousands of years, while it still poses a threat to human health. In addition to routine detections, metagenomic next-generation sequencing (mNGS) has begun to show presence as a ...
Yaoguang Li +7 more
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Metagenomic Next-Generation Sequencing Reveals Porphyromonas gingivalis in Geriatric Severe Pneumonia Complicated by Empyema: Case Report [PDF]
Infection and Drug ResistanceNa Guo,1,* Guannan Ma,2,* Huimin Liu,1 Jingxuan Qiu,1 Yan Yu,1 Yunlei Gao,1 Zhong Yi,1 Zhirong Wan,1 Lei Zhang,2,3 Xiaorui Wu4 1Department of Geriatrics, Aerospace Center Hospital, Beijing, People’s Republic of China; 2Medical Research ...
Guo N +9 more
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Metagenomic Next-Generation Sequencing Unveils Prognostic Microbial Synergism and Guides Precision Therapy in Candidemia: A Retrospective Cohort Study [PDF]
Infection and Drug ResistanceYuhui Chen,1,2 Meng Li,1,2 Xinai Gan,1,2 Yutong Wang,1,2 Xinzhu Tang,1,2 Yongzhao Zhou,3,4 Ting Niu1,5,6 1Department of Hematology, Institute of Hematology, West China Hospital, Sichuan University, Chengdu, People’s Republic of China; 2West China School ...
Chen Y +6 more
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Application of targeted metagenomic next-generation sequencing in pneumonia patients
Microbiology SpectrumAfter the coronavirus disease 2019 (COVID-19) pandemic, the incidence rate of mixed infections, especially in critically ill patients with severe pneumonia, increases due to the immunity gap and has also been proven to be associated with mortality ...
Guanjun Ren +13 more
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Metagenomic Next-Generation Sequencing Reveals Tannerella forsythia in Lung Abscesses: A Retrospective Case Series Linking Smoking, Oral Health, and Diagnostic Challenges [PDF]
Infection and Drug ResistanceWen Wang, Qiongya Mo, Xuchun Ding,* Junjie Pan* Department of Respiratory and Critical Care Medicine, Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, People’s Republic of China*
Wang W, Mo Q, Ding X, Pan J
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Metagenomic Next-Generation Sequencing for Periprosthetic Joint Infections
Cureus, 2023 Periprosthetic joint infection (PJI) after arthroplasty is a major complication, which requires significant resources, resulting in high costs for the medical system. In recent years, significant progress has been made in the diagnosis and treatment of periprosthetic infections, the identification of the pathogen being the central element in the ...
Cretu, Bogdan +6 more
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Epileptic Seizure after Use of Moxifloxacin in Man with Legionella longbeachae Pneumonia
Emerging Infectious Diseases, 2020 Legionellosis caused by Legionella longbeachae is diagnosed mainly by PCR. We report a case of L. longbeachae infection in mainland China, which was diagnosed by metagenomic next-generation sequencing, in a man who developed an epileptic seizure after ...
Jin-Yong Wang +3 more
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Frontiers in Cellular and Infection Microbiology, 2022 IntroductionRapid, sensitive, and specific laboratory assays are critical for the diagnosis and management of central nervous system (CNS) infections. The purpose of this study is to explore the intellectual landscape of research investigating methods ...
Yangyang Guo +6 more
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Emergomyces orientalis Emergomycosis Diagnosed by Metagenomic Next-Generation Sequencing
Emerging Infectious Diseases, 2021 Emergomyces is a newly described dimorphic fungus genus; it may cause fatal infections in immunocompromised patients, but diagnosis is often delayed. We report a case of disseminated emergomycosis caused by the novel species Emergomyces orientalis in a ...
Da He +9 more
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