Results 11 to 20 of about 58,932 (285)

Leishmaniasis Diagnosis via Metagenomic Next-Generation Sequencing [PDF]

Frontiers in Cellular and Infection Microbiology, 2020
Leishmaniasis is a vector-borne disease caused by Leishmania. Although the incidence of leishmaniasis in China is currently low, it has not been completely eradicated.
Hongbin Chen, Chunhong Fan, Hua Gao, Yuyao Yin, Xiaojuan Wang, Yawei Zhang, Hui Wang   +6 more
doaj   +3 more sources

Application of metagenomic next-generation sequencing in cutaneous tuberculosis

Frontiers in Cellular and Infection Microbiology, 2022
Tuberculous infection in a skin wound is a rare but well-known condition. This study describes a child infected with tuberculosis after being wounded. Because of swelling and pain in his wrist tissue, he was admitted to the Affiliated Hospital of Jining ...
Min Kong, Min Kong, Wei Li, Qingsheng Kong, Haixin Dong, Aizhong Han, Liqing Jiang, Liqing Jiang   +7 more
doaj   +3 more sources

Improving Pulmonary Infection Diagnosis with Metagenomic Next Generation Sequencing [PDF]

Frontiers in Cellular and Infection Microbiology, 2021
Pulmonary infections are among the most common and important infectious diseases due to their high morbidity and mortality, especially in older and immunocompromised individuals.
Yi-Yi Qian, Hong-Yu Wang, Yang Zhou, Hao-Cheng Zhang, Yi-Min Zhu, Xian Zhou, Yue Ying, Peng Cui, Hong-Long Wu, Hong-Long Wu, Wen-Hong Zhang, Wen-Hong Zhang, Wen-Hong Zhang, Wen-Hong Zhang, Jia-Lin Jin, Jing-Wen Ai   +15 more
doaj   +3 more sources

Pneumocystis Jirovecii Pneumonia Diagnosis via Metagenomic Next-Generation Sequencing

Frontiers in Medicine, 2022
The incidence of non-HIV-infected Pneumocystis Jirovecii Pneumonia (PJP) is increasing. The prognosis for non-HIV PJP is poor and diagnostic tests are of lower sensitivity in non-HIV patients.
Xiaoxiao Lu, Jianhui Zhang, Jianhui Zhang, Wentao Ma, Lihua Xing, Hanbing Ning, Mengying Yao   +6 more
doaj   +3 more sources

Emergomyces orientalis Emergomycosis Diagnosed by Metagenomic Next-Generation Sequencing [PDF]

Emerging Infectious Diseases, 2021
Emergomyces is a newly described dimorphic fungus genus; it may cause fatal infections in immunocompromised patients, but diagnosis is often delayed. We report a case of disseminated emergomycosis caused by the novel species Emergomyces orientalis in a ...
Da He, Min Quan, Hongyan Zhong, Zhixing Chen, Xioahui Wang, Fang He, Junyan Qu, Taoyou Zhou, Xiaoju Lv, Zhiyong Zong   +9 more
doaj   +3 more sources

Clinical Metagenomic Next-Generation Sequencing for Pathogen Detection [PDF]

Annual Review of Pathology: Mechanisms of Disease, 2019
Nearly all infectious agents contain DNA or RNA genomes, making sequencing an attractive approach for pathogen detection. The cost of high-throughput or next-generation sequencing has been reduced by several orders of magnitude since its advent in 2004, and it has emerged as an enabling technological platform for the detection and taxonomic ...
Gu, Wei, Miller, Steve, Chiu, Charles Y
openaire   +6 more sources

Chronic Meningitis Investigated via Metagenomic Next-Generation Sequencing [PDF]

JAMA Neurology, 2018
Identifying infectious causes of subacute or chronic meningitis can be challenging. Enhanced, unbiased diagnostic approaches are needed.To present a case series of patients with diagnostically challenging subacute or chronic meningitis using metagenomic next-generation sequencing (mNGS) of cerebrospinal fluid (CSF) supported by a statistical framework ...
Wilson, Michael R, O’Donovan, Brian D, Gelfand, Jeffrey M, Sample, Hannah A, Chow, Felicia C, Betjemann, John P, Shah, Maulik P, Richie, Megan B, Gorman, Mark P, Hajj-Ali, Rula A, Calabrese, Leonard H, Zorn, Kelsey C, Chow, Eric D, Greenlee, John E, Blum, Jonathan H, Green, Gary, Khan, Lillian M, Banerji, Debarko, Langelier, Charles, Bryson-Cahn, Chloe, Harrington, Whitney, Lingappa, Jairam R, Shanbhag, Niraj M, Green, Ari J, Brew, Bruce J, Soldatos, Ariane, Strnad, Luke, Doernberg, Sarah B, Jay, Cheryl A, Douglas, Vanja, Josephson, S Andrew, DeRisi, Joseph L   +31 more
openaire   +6 more sources

Metagenomic next-generation sequencing for mixed pulmonary infection diagnosis [PDF]

BMC Pulmonary Medicine, 2019
Background Metagenomic next-generation sequencing (mNGS) is emerging as a promising technique for pathogens detection. However, reports on the application of mNGS in mixed pulmonary infection remain scarce.
Jiahui Wang, Yelei Han, Jing Feng
doaj   +4 more sources

Assessment of metagenomic assembly using simulated next generation sequencing data. [PDF]

PLoS ONE, 2012
Due to the complexity of the protocols and a limited knowledge of the nature of microbial communities, simulating metagenomic sequences plays an important role in testing the performance of existing tools and data analysis methods with metagenomic data ...
Daniel R Mende, Alison S Waller, Shinichi Sunagawa, Aino I Järvelin, Michelle M Chan, Manimozhiyan Arumugam, Jeroen Raes, Peer Bork   +7 more
doaj   +6 more sources

Application of metagenomic next-generation sequencing and targeted metagenomic next-generation sequencing in diagnosing pulmonary infections in immunocompetent and immunocompromised patients

Frontiers in Cellular and Infection Microbiology
BackgroundMetagenomic next-generation sequencing (mNGS) technology has been widely used to diagnose various infections. Based on the most common pathogen profiles, targeted mNGS (tNGS) using multiplex PCR has been developed to detect pathogens with ...
Yong Liu, Wencai Wu, Yunping Xiao, Hongyan Zou, Sijia Hao, Yanfang Jiang   +5 more
doaj   +3 more sources