Results 51 to 60 of about 209,835 (241)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Visualising text co-occurrence networks [PDF]

, 2016
We present a tool for automatically generating a visual summary of unstructured text data retrieved from documents, web sites or social media feeds. Unlike tools such as word clouds, we are able to visualise structures and topic relationships occurring in a document. These relationships are determined by a unique approach to co-occurrence analysis. The
Hirsch, Laurie, Andrews, Simon
openaire  

Deciphering microeukaryotic–bacterial co-occurrence networks in coastal aquaculture ponds

Marine Life Science & Technology, 2023
AbstractMicroeukaryotes and bacteria are key drivers of primary productivity and nutrient cycling in aquaculture ecosystems. Although their diversity and composition have been widely investigated in aquaculture systems, the co-occurrence bipartite network between microeukaryotes and bacteria remains poorly understood.
Zheng, Xiafei, Xu, Kui, Naoum, Jonathan, Lian, Yingli, Wu, Bo, He, Zhili, Yan, Qingyun   +6 more
openaire   +2 more sources

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Plant–mycorrhizal fungus co‐occurrence network lacks substantial structure

Oikos, 2015
The interactions between plants and arbuscular mycorrhizal fungi (AMF) maintain a crucial link between macroscopic organisms and the soil microbial world. These interactions are of extreme importance for the diversity of plant communities and ecosystem functioning.
Francisco Encinas‐Viso, David Alonso, John N. Klironomos, Rampal S. Etienne, Esther R. Chang   +4 more
openaire   +3 more sources

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Unbalanced diets enhance the complexity of gut microbial network but destabilize its stability and resistance

Stress Biology, 2023
Stability is a fundamental ecological property of the gut microbiota and is associated with host health. Numerous studies have shown that unbalanced dietary components disturb the gut microbial composition and thereby contribute to the onset and ...
Penghao Sun, Mengli Wang, Wei Zheng, Shuzhen Li, Xiaoyan Zhu, Xuejun Chai, Shanting Zhao   +6 more
doaj   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Suspended particulates mediate bacterial community coalescence in different habitats of a large sediment-laden river

Ecological Indicators, 2022
Many studies have reported the influence of dispersal processes on aquatic bacterial communities, but the role of community coalescence is still unknown in sediment-laden rivers.
Baozhu Pan, Xinyuan Liu, He Sun, Yitong Ding, Yiming Hou, Qingwei zhu   +5 more
doaj   +1 more source

Using null models to infer microbial co-occurrence networks

PLOS ONE, 2016
AbstractAlthough microbial communities are ubiquitous in nature, relatively little is known about the structural and functional roles of their constituent organisms’ underlying interactions. A common approach to study such questions begins with extracting a network of statistically significant pairwise co-occurrences from a matrix of observed ...
Connor, Nora, Barberán, Albert, Clauset, Aaron   +2 more
openaire   +4 more sources