Results 241 to 250 of about 31,900 (295)

Parent-of-origin effects on complex traits in up to 236,781 individuals. [PDF]

open access: yesNature
Hofmeister RJ   +14 more
europepmc   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

open access: yesFEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo   +7 more
wiley   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

open access: yesFEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin   +3 more
wiley   +1 more source

Base editing in the AUTS2 gene and high-throughput NGS genotyping of clones: a strategy for generating a cellular model. [PDF]

open access: yesVavilovskii Zhurnal Genet Selektsii
Yan AP   +10 more
europepmc   +1 more source

Antisense oligonucleotides to KIF1A polymorphisms expand targets and rescue patient-derived neurons in vitro. [PDF]

open access: yesNat Commun
Zuccaro MV   +13 more
europepmc   +1 more source

A rapid accurate approach to inferring pedigrees in endogamous populations. [PDF]

open access: yesGenetics
Williams CM   +12 more
europepmc   +1 more source

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