Results 71 to 80 of about 31,900 (295)

Some Simple Economics of Energy Transition

Substantia, 2019
After explaining the current climate emergency, this survey article summarises financial cost estimates for transition to zero carbon by 2050, which even in the medium term, neglecting catastrophic climate collapse, are much less than the cost of ...
Felix FitzRoy
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Role of Fe/Co Ratio in Dual Phase Ce0.8gd0.2o2− Δ –Fe3-Xcoxo4 Composites for Oxygen Separation

, 2023
Liudmila Fischer, Ke Ran, Christina Schmidt, Kerstin Neuhaus, Joachim Mayer, Patrick Behr, H.J.M. Bouwmeester, Arian Nijmeijer, Stefan Baumann, W.A. Meulenberg   +9 more
openalex   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

The formation of CO$_2$ through consumption of gas-phase CO on vacuum-UV irradiated water ice

, 2022
J. Terwisscha van Scheltinga, N. F. W. Ligterink, A. D. Bosman, M. R. Hogerheijde, H. Linnartz   +4 more
openalex   +1 more source

Satellite-Based Assessment of Spatially Heterogeneous XCO₂ and Marine pCO₂ Trends (2015–2020)

Remote Sensing
Satellite remote sensing has revolutionized the monitoring of atmospheric carbon dioxide (CO2) concentrations, yet its integration into studies of air–sea CO2 flux dynamics remains limited. Leveraging high-resolution observations from the Orbiting Carbon
Siqi Zhang, Zhenhua Zhang, Peng Chen, Haiqing Huang, Delu Pan   +4 more
doaj   +1 more source

The Virtual Teacher (VT) Paradigm: Learning New Patterns of Interpersonal Coordination Using the Human Dynamic Clamp.

PLoS ONE, 2015
The Virtual Teacher paradigm, a version of the Human Dynamic Clamp (HDC), is introduced into studies of learning patterns of inter-personal coordination.
Viviane Kostrubiec, Guillaume Dumas, Pier-Giorgio Zanone, J A Scott Kelso   +3 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source