Results 81 to 90 of about 31,900 (295)

Assessing effectiveness of serious game training designed to assist in upper limb prosthesis rehabilitation

Frontiers in Rehabilitation Sciences
IntroductionControlling a myoelectric upper limb prosthesis is difficult, therefore training is required. Since training with serious games showed promising results, the current paper focuses on game design and its effectivity for transfer between in ...
Bart Maas, Corry K. Van Der Sluis, Raoul M. Bongers   +2 more
doaj   +1 more source

Implementation of thermal and fuel stratification strategies to extend the load limit of HCCI engine

Journal of Thermal Science and Technology, 2019
The HCCI engine can be a possible potential engine technology that gives high performance with fewer dangerous exhaust emissions. In HCCI engines, low-temperature combustion of lean, highly premixed charge effectively reduces the NOX and soot.
Amit KARWADE, Shashikant THOMBRE
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

GDNF‐RET signaling drives pulmonary neuroendocrine cell hyperplasia and allergic airway inflammation

FEBS Letters, EarlyView.
A neuroimmune interaction centered on the PNEC‐ILC2 axis in an asthma model. PNEC‐derived CGRP activates nearby ILC2s, which then release cytokines, including IL‐5 and IL‐13. These cytokines promote eosinophil and macrophage infiltration. Subsequently, GDNF produced by these cells induces PNEC hyperplasia via the GDNF receptors, RET and GFRα1 ...
Tasuku Kawano, Erina Ike, Suguru Okada, Tomoko Takahashi   +3 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Structure of a 13-fold superhelix (almost) determined from first principles

IUCrJ, 2015
Nuclear hormone receptors are cytoplasm-based transcription factors that bind a ligand, translate to the nucleus and initiate gene transcription in complex with a co-activator such as TIF2 (transcriptional intermediary factor 2).
Guillaume A. Schoch, Massimo Sammito, Claudia Millán, Isabel Usón, Markus G. Rudolph   +4 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Specific heat of stage-2 MnCl$_{2}$ graphite intercalation compound: co-existence of spin glass phase and incommensurate short-range spin order [PDF]

, 2009
Masatsugu Suzuki, Itsuko S. Suzuki, Tadashi Adachi, Yōji Koike   +3 more
openalex   +1 more source

Equi‐MOI ratio for rapid baculovirus‐mediated multiprotein co‐expression in insect cells integrating selenomethionine for structural studies

FEBS Open Bio
Proteins often co‐exist as multicomponent assemblies, making their co‐expression essential in recombinant production processes. The baculovirus expression vector system is commonly used to produce recombinant multiprotein complexes mostly for structural ...
Andrej Bitala, Mário Benko, Marek Nemčovič, Ivana Nemčovičová   +3 more
doaj   +1 more source

CFD Simulation of Pre-Chamber Spark-Ignition Large Bore CNG Engine: Model Development, Practical Applications, and Experimental Validation

Energies
This study develops and validates a three-dimensional CFD model for a 12 L large-bore active-type pre-chamber spark-ignition (PCSI) engine fueled by natural gas.
Soo-Jin Jeong, Seokpan Seo, Seong-Joon Moon   +2 more
doaj   +1 more source