Results 71 to 80 of about 1,816,176 (258)

Development and Application of One-Trip Dissoluble Hollow Whipstock

open access: yesShiyou jixie
To solve the problems of cumbersome operation process, high cost and risk in the connection process of main and lateral holes existed in the current one-trip sidetracking technology, a one-trip dissoluble hollow whipstock was developed.
Guan Yanlei Zhao Jincheng Chen Jie Chen Liwei Wang Yue Yan Wei   +1 more
doaj   +1 more source

Co-Production in Community Development

open access: yes, 2018
Community development is a good case to assess how co-creation and co-production can have an impact on local neighbourhoods. One often-used illustration of the success of co-production in community development is the well-known case of Porto Alegre in Brazil.
Vanleene, D., Verschuere, B.
openaire   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

An experimental study on the CO2/sand dry-frac process

open access: yesNatural Gas Industry B, 2014
The CO2/sand dry-frac process is a waterless fracturing technology in which CO2 instead of water is used as fracturing fluid. The application of the technology abroad (in the USA and Canada) shows that it works well in stimulating low-pressure, low ...
Song Zhenyun   +8 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Development Characteristics and Controlling Factors of Deep-Water Deep Tight Sandstone Sweet-Spot Reservoirs in the Baodao Sag, Qiongdongnan Basin

open access: yesApplied Sciences
Medium-deep tight sandstone reservoirs represent a new frontier for hydrocarbon exploration. Great natural gas exploration breakthroughs have been made in the third member of the Lingshui Formation in the Baodao Sag, Qiongdongnan Basin.
Lei Zheng   +7 more
doaj   +1 more source

Cultivation of Sweet Sorghum (Sorghum bicolor (L.) Moench) and Determination of its Harvest Time to Make Use as the Raw Material for Fermentation, Practiced during Rainy Season in Dry Land of Indonesia

open access: yesPlant Production Science, 2004
We cultivated sweet sorghum cultivars – Wray, Keller and Rio – to confirm the feasibility of cultivation in dry land of Indonesia for monosodium glutamate (MSG) production. Stem yield of Wray was 4,790 ~ 6,593 g m−2.
Naoyuki Tsuchihashi, Yusuke Goto
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

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