Results 41 to 50 of about 7,877,554 (342)
Research on the Volumetric Efficiency of a Novel Stacked Roller 2D Piston Pump
Machines, 2021 In order to improve the volumetric efficiency of the axial piston pump, this paper proposes a novel stacked roller 2D piston pump. It utilizes the alternate communication between the distribution cylinder and the oil intake and discharge ports of the ...
Chenchen Zhang +5 more
doaj +1 more source
Heterogeneous co-simulation for embedded and cyber-physical systems design
, 2020 The growing complexity of embedded and cyber-physical systems makes the design of all system components from scratch increasingly impractical. Consequently, already from early stages of a design flow, designers rely on prior experience, which comes in ...
Sander, Ingo,, Attarzadeh-Niaki, S. -H
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Energies, 2022 Building models and their connected subsystems are often simulated as standalone entities. However, in order to monitor a system′s reactions to changing parameters and to assess its energy efficiency, it must be exposed to the actual dynamic context of ...
Abdelhak Kharbouch +5 more
doaj +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Checking SysML Models for Co-simulation
, 2016 Cyber-physical systems (CPSs) are often treated modularly to tackle both complexity and heterogeneity; and their validation may be done modularly by co-simulation: the coupling of the individual subsystem simulations. This modular approach underlies the FMI standard.
Nuno Amálio +3 more
openaire +2 more sources
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Co-simulation of Event-B and Ptolemy II Models via FMI [PDF]
, 2014 In the framework of model-based design formal modelling, verification and simulation of safety-critical systems are supported by several methods and tools. Interfacing these tools often becomes challenging for heterogeneous systems.
Savicks, Vitaly +3 more
core
Enabling Python Driven Co-Simulation Models with PythonFMU [PDF]
, 2020 This paper introduces PythonFMU, an easy to use framework for exporting Python 3.x code as cosimulation compatible models compliant with version 2.0 of the Functional Mock-up Interface (FMI).
Frederic Collonval +5 more
core +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source