Results 51 to 60 of about 302,864 (297)

Development of Economic Water Usage Sensor and Cyber-Physical Systems Co-Simulation Platform for Home Energy Saving [PDF]

open access: yes, 2017
In this thesis, two Cyber-Physical Systems (CPS) approaches were considered to reduce residential building energy consumption. First, a flow sensor was developed for residential gas and electric storage water heaters.
Singer, Joe
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

AER and dynamic systems co-simulation over Simulink with Xilinx System Generator [PDF]

open access: yes, 2008
Address-Event Representation (AER) is a neuromorphic communication protocol for transferring information of spiking neurons implemented into VLSI chips.
Civit Balcells, Antón   +5 more
core  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Robot virtual prototype in ADAMS [PDF]

open access: yes, 2012
Tato práce se zabývá vytvořením virtuálního modelu robotu v ADAMS a co-simulačním propojením tohoto modelu s návrhem řízení v Matlab/Simulink. Robotem je segway Pierot vytvořený v rámci předchozích závěrečných prací. Obsahem této práce je vytvoření multi-
Příleský, Libor
core  

Checking SysML Models for Co-simulation

open access: yes, 2016
Cyber-physical systems (CPSs) are often treated modularly to tackle both complexity and heterogeneity; and their validation may be done modularly by co-simulation: the coupling of the individual subsystem simulations. This modular approach underlies the FMI standard.
Nuno Amálio   +3 more
openaire   +2 more sources

Behavioural Models for FMI Co-simulations [PDF]

open access: yes, 2016
Simulation is a favoured technique for analysis of cyber-physical systems. With their increase in complexity, co-simulation, which involves the coordinated use of heterogeneous models and tools, has become widespread. An industry standard, FMI, has been developed to support orchestration; we provide the first behavioural semantics of FMI.
Cavalcanti, A. L. C.   +2 more
openaire   +3 more sources

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Co-Simulation of Hybrid Systems with SpaceEx and Uppaal [PDF]

open access: yes, 2015
The Functional Mock-up Interface (FMI) is an industry standard which enables co-simulation of complex heterogeneous systems using multiple simulation engines.
Bogomolov, Sergiy   +6 more
core   +3 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

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