Results 61 to 70 of about 7,877,554 (342)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Co-simulation of bio-inspired multi-agent algorithms

, 2020
This paper reports on the co-simulation of a team of robots deployed in an exploration task, coordinated by a bio-inspired exploration algorithm. The co-simulation integrates the high-level exploration algorithm with detailed implementations of the robot
Fagiolini A., Palmieri M., Domenici A., Bernardeschi C.   +3 more
core  

Operating Performance of Pure Electric Loaders with Different Types of Motors Based on Simulation Analysis

Energies, 2021
The electrification of loader designs can utilise several power motor types. Hence, this study investigates the operational performance of pure electric-powered loaders matched with three types of motors. Firstly, for the ZL08 loader, it is proposed that
Xuefei Li, Chao Duan, Kun Bai, Zongwei Yao   +3 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Distributed hierarchical control of islanded active distribution networks with dynamic consensus algorithm and adaptive virtual impedance

Frontiers in Energy Research
In the event of an upstream grid fault, the Active Distribution Network (ADN) can switch to autonomous operation, coordinating controllable Distributed Generators (DGs) and Energy Storage Systems (ESS) to maintain power supply reliability.
Xiaoyun Wang, Xiaoyun Wang, Zimin Zhu, Zimin Zhu, Yu Duan, Yu Duan, Xiaofang Wu, Xiaofang Wu, Jian Ma, Jian Ma, Xing Ma, Xing Ma   +11 more
doaj   +1 more source

Augmented Reality Mapping of Rock Mass Discontinuities and Rockfall Susceptibility Based on Unmanned Aerial Vehicle Photogrammetry

Remote Sensing, 2019
In rockfall hazard management, the investigation and detection of potential rockfall source areas on rock cliffs by remote-sensing-based susceptibility analysis are of primary importance.
Yichi Zhang, Pan Yue, Guike Zhang, Tao Guan, Mingming Lv, Denghua Zhong   +5 more
doaj   +1 more source

Building Distributed Co-Simulations Using CoHLA [PDF]

2018 21st Euromicro Conference on Digital System Design (DSD), 2018
The construction of a co-simulation for large cyber-physical systems can be very time consuming. We have defined a domain specific language called CoHLA that facilitates this construction based on the standards FMI and HLA. Scalability of this approach is investigated by the application to Internet of Things (IoT) systems.
Thomas Nägele, Jozef Hooman, Jack Sleuters   +2 more
openaire   +3 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Co-Simulation of Algebraically Coupled Dynamic Subsystems [PDF]

Dynamic Systems and Control, 2001
Abstract This paper analyzes the problem of Co-Simulation. The term Co-Simulation is used to describe a large dynamic system that is simulated by running a group of independently coded subsystem simulators. Very commonly, the Co-Simulation of subsystems faces incompatible boundary conditions, i.e., causal conflicts.
Bei Gu, H. Harry Asada
openaire   +2 more sources

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source