Results 61 to 70 of about 1,961,078 (257)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

The impact of long-term elevated CO2 on C and N retention in stable SOM pools [PDF]

, 2008
Elevated atmospheric CO2 frequently increases plant production and concomitant soil C inputs, which may cause additional soil C sequestration. However, whether the increase in plant production and additional soil C sequestration under elevated CO2 can be
Kessel, C., van, Six, J., Graaff, M.A., de   +2 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Some Questions for Communities and Developers Interested in Hosting Carbon Capture and Utilization Projects

This document was created to support communities and developers in their efforts to create clear expectations for carbon capture and utilization (CCU) projects.
Global CO2 Initiative
core   +1 more source

Climate-dependent CO2 emissions from lakes [PDF]

, 2010
Inland waters, just as the world's oceans, play an important role in the global carbon cycle. While lakes and reservoirs typically emit CO2, they also bury carbon in their sediment.
Sternberg, Leonel da S. L, Nes, E.H., van, Mazzeo, N., Da Motta Marques, David M. L, Scheffer, M., Van Nes, Egbert H, Cole, J.J., Mazzeo, Néstor, Cole, Jon J, Sternberg, L.S.L., Kosten, Sarian, Roland, Fábio, Da Motta Marques, D.M.L., Scheffer, Marten, Kosten, S., Motta Marques, D.M.L., Da, Roland, F., van Nes, E.H.   +17 more
core   +1 more source

Temperature-dependent co-adsorption of H2O and CO2 by aminated porous solid adsorbers for direct air capture

Sustainable Chemistry for Climate Action
We hypothesize that dynamic aspects of the chemisorption of CO2 and co-adsorption of H2O on aminated adsorbents are highly important when used in direct air capture (DAC) technologies.
Dennis Prietzel, Johanna Fricke, Pierre Stiernet, Marc Rüggeberg, Christine Schütz, Nadine Simon, Jiayin Yuan, Niklas Hedin   +7 more
doaj   +1 more source

Effect of Dominant Fatty Acid Esters on Emission Characteristics of Waste Animal Fat Biodiesel in CI Engine

Frontiers in Energy Research, 2019
This present study aims in understanding the influence of dominant fatty acid esters of waste animal fat biodiesel on its emission characteristics in CI engine.
Ranjitha Jambulingam, Vijayalakshmi Shankar, Shalini Palani, Gokul Raghavendra Srinivasan, Gokul Raghavendra Srinivasan   +4 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

The transcriptome of Populus in elevated CO2 reveals increased anthocyanin biosynthesis during delayed autumnal senescence [PDF]

, 2010
The delay in autumnal senescence that has occurred in recent decades has been linked to rising temperatures. Here, we suggest that increasing atmospheric CO2 may partly account for delayed autumnal senescence and for the first time, through transcriptome
Tallis, M.J., Street, N.R., Calfapietra, C., Street, N. R., DeAngelis, P., Tallis, Matthew, C. Calfapietra, Street, N., M. J. Tallis, Karnosky, D., Karnosky, D. F., De Angelis, P., Zhang, J., F. Miglietta, G. Taylor, Taylor, G., Tallis, M. J., J. Zhang, N. R. Street, P. De Angelis, Rogers, A., Y. Lin, Lin, Y., Karnosky, D.F., D. F. Karnosky, A. Rogers, Miglietta, F.   +26 more
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source