Results 91 to 100 of about 4,064,010 (293)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

CO2 conversion to CO by fluidized bed biomass gasification: Analysis of operational parameters

Journal of CO2 Utilization
Thermochemical conversion of CO2 with biomass to CO in fluidized bed gasifiers is promising for a sustainable carbon economy. Knowledge about this process is expanded by investigating experimental parameters influencing CO2 conversion in such a system ...
Florian J. Müller, Josef Fuchs, Miguel Fanjul Cuesta, Ana Oblanca Gutiérrez, Simon Pratschner, Stefan Müller, Franz Winter   +6 more
doaj   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Cutting-edge development in waste-recycled nanomaterials for energy storage and conversion applications

Nanotechnology Reviews, 2022
Abd Elkodous Mohamad, Hamad Hesham A., Abdel Maksoud Mohamad I. A., Ali Gomaa A. M., El Abboubi Mouna, Bedir Ahmed G., Eldeeb Ahmed A., Ayed Abdelmoneim A., Gargar Zineb, Zaki Fatma S., Farage Dina A. M., Matsuda Atsunori, Abdelnour Marina R., Sabra Bassant A., Elsayed Ali, Abdelrazek Taghreed A., Abdelhameed Salma T., Gharieb Mohamed A., Rabee Maisara M., Aboeldiar Sahar A., Abdo Nadeen A., Elwakeel Abdullah M., Mahmoud Amira S., Elsaid Moustafa M. M., Omar Wafaa M., Hania Rinad Abu, Mahmoud Nouran G., Elsayed Ahmed S. S., Mohamed Tarek M., Sewidan Muhamed A., Sayed Mostafa A. M., Abbas Abdulrahman A., Elsayed Ahmed H., Alazab Alaa Marouf, Basyooni Mohamed A., Magdy Mona, Mashaly Eman A., Salem Omnia M., Saber Suzan, Hafez Ahmad Ali, Tan Wai Kian, Kawamura Go   +41 more
doaj   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Recent Progress in CO2 Conversion: An Overview of Catalytic Strategies for Sustainable Fuel and Chemical Synthesis

SmartMat
The conversion of carbon dioxide (CO2) into value‐added chemicals and renewable fuels is a promising approach to mitigate climate change and promote the development of sustainable energy systems. However, despite the broad range of products, including CO,
An Zhang, Yanming Cai, Liang Guo, Chao Wang, Qingbo Wa, Yanping Xu, Jian Zhou, Hongshuang Fan, Ziyun Li, Xinyue Long, Jiabei Tang, Zijian Li, Li Zhai, Zhenyu Shi, Wei Zhai, Yuhui Tian, Shuai Bi, Hao Wei, Mingliang Hu, Yang Xu, Yiran Zhang, Yu Zhang, Ruiying Ding, Junjun Li, Shuangqun Chen, Jianfeng Huang, Zhanxi Fan, Xingchen Jiao, Guigao Liu, Haiqing Wang, Haifeng Tian, Jingyu Pang, Kuncheng Zhang, Weisong Liu, Huijuan Cui, Lingling Zhang, Xiaofu Sun, Jianling Zhang, Dan Ren, Sheng Zhang, Lu Qiao, Zhe Weng, Hongmei Li, Min Liu, Miao Zhong, Lei Wang, Jun Gu, Hao Bin Wu, Bolong Huang, Weijia Zhou, Chuan Xia, Min‐Rui Gao, Changbin Zhang, Rong Cao, Wei Chen, Yuan‐Biao Huang, Yongye Liang, Ya‐Qian Lan, Guoxiong Wang, Baoyu Xia, Yujie Xiong, Xinbin Ma, Tongbu Lu, Jinhua Ye, Yi Xie, Buxing Han, Jiawei Liu, Zhicheng Zhang, Hua Zhang   +68 more
doaj   +1 more source

A review of catalytic conversion of carbon dioxide to gas: Applications, challenges, and future development directions

Journal of CO2 Utilization
Catalytic conversion of CO2 is a clean technology that converts CO2 into usable energy, possessing significant environmental protection and energy utilization value. This article reviews the reaction mechanism, catalyst types and performance, challenges,
Junlin He, Chao Feng, Tao Lin, Mingwei Tu, Rong Zhu, Yanhong Wang, Huapeng Yang, Shanghai Yi, Guangsheng Wei, Xiaoling Wang, Jie Zhang   +10 more
doaj   +1 more source