Results 41 to 50 of about 73,663 (246)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Analyzing the phased changes of socioeconomic drivers to carbon dioxide and particulate matter emissions in the Yangtze River Delta

Ecological Indicators, 2022
Enhancing the environmental collaborative governance to reduce carbon dioxide (CO2) and particulate matter (PM2.5) emissions is an important and significant low-carbon green growth strategy in China.
Huaxing Lin, Ping Jiang
doaj   +1 more source

CO2 emissions: a dynamic structural analysis

Revista de Administração da UFSM, 2021
Purpose - The purpose of this article is to analyze the impact of energy consumption and economic growth on CO2 emissions worldwide and to present the temporary evolution of CO2 emissions during the pandemic. Design/methodology/approach - The final sample was composed of 72 countries observed for a period of 15 years; the data were collected in the ...
Marco Aurelio Vieira, Paulo Sergio Ceretta   +1 more
openaire   +3 more sources

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Forecasting interactive relationships and long-term equilibrium of CO2 emissions in industrial interdependent regions

Carbon Management, 2020
This is the first study that analyses the interactive relationships of carbon dioxide (CO2) emissions between China and Taiwan, two industrial dependent regions, by applying Lotka-Volterra equations.
Bi-Huei Tsai, Cheng-Chi Chen
doaj   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Brazilian Productive Structure and Co2 Emissions [PDF]

SSRN Electronic Journal, 2010
This paper analyzes the relation between economic performance and CO2 emissions in Brazil, in the year 2004. The contribution of the productive sectors to total emission is established, taking into account the technological structure of the economy, the interrelations among sectors, the sectoral capacity of generating value-added and the participation ...
Imori, Denise, Guilhoto, Joaquim José Martins   +1 more
openaire   +1 more source

Sustainable bioplastics manufacturing from renewable sources

FEBS Open Bio, EarlyView.
Bioplastics are manufactured by using polymers from different bio‐based sources. These novel materials not only offer biodegradability but also possess various functional properties that make them suitable for diverse applications. Recent developments in the preparation of bioplastics are reported, highlighting the distinct properties of each type of ...
C. Valeria L. Giosafatto, Marika Avitabile, Michela Famiglietti, Talayeh Kordjazi, Marzieh Moosavi‐Nasab, Odile F. Restaino, Loredana Mariniello   +6 more
wiley   +1 more source

Dynamic spatial spillover effects of financial agglomeration on CO2 emissions: the case of China

Humanities & Social Sciences Communications
Research on the impact of financial agglomeration on CO2 emissions is a vital avenue for advancing CO2 emissions reduction and aligning with the Sustainable Development Goals set forth by the United Nations.
Jun Wan, Chenggang Li, Zhangting Yang, Liang Wu, Mu Yue   +4 more
doaj   +1 more source