Results 41 to 50 of about 644,330 (242)

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Biocatalytic Reduction of Formaldehyde to Methanol: Effect of pH on Enzyme Immobilization and Reactive Membrane Performance

Bulletin of Chemical Reaction Engineering & Catalysis, 2021
Thermodynamic stabled CO2 molecules can be biocatalytically reduced to methanol via three cascade dehydrogenases (formate, formaldehyde and alcohol) with the aid of cofactor as the electron donor.
Norhayati Abdul Rahman, Fauziah Marpani, Nur Hidayati Othman, Nur Hashimah Alias, Junaidah Jai, Nik Raikhan Nik Him   +5 more
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

New experiences with foamed bitumen asphalts in hungarian road building

Romanian Journal of Transport Infrastructure, 2015
The use of low temperature (LT) asphalt products can result in a significant decrease of temperature required for asphalt production. This reduces energy costs and consumption.
Puchard Zoltan, Gorgenyi Agnes
doaj   +1 more source

High-efficiency carbon dioxide reduction using catalytic nonthermal plasma desorption

Mechanical Engineering Journal, 2023
To sustainably reduce carbon dioxide (CO2) emissions at ambient temperature and atmospheric pressure, CO2 is reduced to carbon monoxide (CO) using nonthermal plasma (NTP) flow and a catalyst.
Hiroyuki WAKIMOTO, Haruhiko YAMASAKI, Tomoyuki KUROKI, Masaaki OKUBO   +3 more
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Renewable production of nylon precursors from lignin

Cell Reports Sustainability
Summary: Cyclohexanone and cyclohexanol are critical monomeric precursors in the production of nylon 6 and nylon 66, which are conventionally sourced from petroleum.
Kaile Li, Shijie Yu, Alexandra Radu, Yongqing Xu, Juniza Md Saad, Badr A. Mohamed, Qinghai Li, Yanguo Zhang, Zhicheng Luo, Hui Zhou   +9 more
doaj   +1 more source

Emerging applications of nanodiamonds in photocatalysis

Functional Diamond, 2022
As a fascinating nanocarbon photocatalytic material, nanodiamonds (NDs) have attracted more and more attention recently due to their high chemical stability, high carrier mobility, narrowing band gap, easy surface modification, and mass production.
Li-Xia Su, Yu Cao, Hao-Shan Hao, Qi Zhao, Jinfang Zhi   +4 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source