Results 41 to 50 of about 7,836,779 (233)

Enhancing physical fitness in older adults: a six-month medium intensity training intervention yields significant improvements

BMC Sports Science, Medicine and Rehabilitation
Background Maintaining physical fitness in older adults is crucial for preventing functional decline. This study aimed to examine the effects of a 6-month medium-intensity training (MIT) programme on physical fitness components in older adults.
Rahmat Hidayat, Wangang Lv, Danyang Li, Stuart Goodall   +3 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

The opportunities and challenges of virtual coach education in rural and remote communities

Frontiers in Sports and Active Living
IntroductionWithin sport for development (SFD), it has been widely established that coaches—and the presence of strong adult relationships—play a critical role in facilitating a broad array of positive youth outcomes.
Carrie W. LeCrom, Kalyn McDonough Smith
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Repeated sprint performance and fatigue responses across different movement patterns in amateur soccer players

BMC Sports Science, Medicine and Rehabilitation
Background The objective of this study was to examine the differences in neuromuscular fatigue, physiological responses, and physical performance between the Curved (Bangsbo) Repeated Sprint Ability Test (C-RSA) and the Linear Repeated Sprint Ability ...
Erhan Işıkdemir, Mehmet Emre Kılıç, Fevzican Kelebek   +2 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

A Preliminary Investigation of the Relationship of Three Key Bar Positions on Weightlifting Performance

International Journal of Strength and Conditioning
Background: There are three fundamental bar positions in weightlifting: 1) Set-up (S), 2) Knee (K), and 3) Power Position (P). Commonly, these positions are evaluated using a clean-grip isometric pull.
Wesley Gawel, Marten Bauer, Chieh-Hsin You, Kyle Rochua, Daniel Gahreman, Guy Hornsby, Satoshi Mizuguchi, Michael Stone   +7 more
doaj   +1 more source

Resting Hormone Alterations and Injuries: Block vs. DUP Weight-Training among D-1 Track and Field Athletes

Sports, 2018
Daily undulating periodization (DUP), using daily alterations in repetitions, has been advocated as a superior method of resistance training, while traditional forms of programming for periodization (Block) have been questioned. Nineteen Division I track
Keith B. Painter, G. Gregory Haff, N. Travis Triplett, Charles Stuart, Guy Hornsby, Mike W. Ramsey, Caleb D. Bazyler, Michael H. Stone   +7 more
doaj   +1 more source

Alterations in Adiponectin, Leptin, Resistin, Testosterone, and Cortisol across Eleven Weeks of Training among Division One Collegiate Throwers: A Preliminary Study

Journal of Functional Morphology and Kinesiology, 2020
Cytokine and hormone concentrations can be linked to the manipulation of training variables and to subsequent alterations in performance. Subjects: Nine D-1 collegiate throwers and 4 control subjects participated in this preliminary and exploratory ...
W. Guy Hornsby, G. Gregory Haff, Dylan G. Suarez, Michael W. Ramsey, N. Travis Triplett, Justin P. Hardee, Margaret E. Stone, Michael H. Stone   +7 more
doaj   +1 more source