Results 1 to 10 of about 689,025 (351)

Dogs with sepsis are more hypercoagulable and have higher fibrinolysis inhibitor activities than dogs with non-septic systemic inflammation. [PDF]

Front Vet Sci
IntroductionHemostatic imbalance in dogs with sepsis is characterized by hypercoagulability and hypofibrinolysis. We aimed to determine whether these abnormalities are unique features of sepsis or are also present in dogs with non-septic critical illness.
Hill E, Zhu Y, Brooks MB, Goggs R.
europepmc   +2 more sources

Utility of ACMG classification to support interpretation of molecular genetic test results in patients with factor VII deficiency

Frontiers in Medicine, 2023
BackgroundThe American College of Medical Genetics and Genomics (ACMG) and the Association for Molecular Pathology (AMP) have introduced an internationally shared framework for variant classification in genetic disorders.
Rosa Sonja Alesci, Carola Hecking, Benjamin Racké, Detlev Janssen, Carl-Erik Dempfle   +4 more
doaj   +1 more source

Recombinant factor IX‐Fc fusion protein in severe hemophilia B: Patient‐reported outcomes and health‐related quality of life

Research and Practice in Thrombosis and Haemostasis, 2021
Introduction In 2017, all people with severe hemophilia B in Ireland switched to recombinant factor IX Fc fusion protein concentrate (rFIXFc) prophylaxis.
Mairead O’Donovan, Eimear Quinn, Kate Johnston, Evelyn Singleton, Julie Benson, Brian O'Mahony, Declan Noone, Cleona Duggan, Ruth Gilmore, Kevin Ryan, James S. O'Donnell, Niamh M. O’Connell   +11 more
doaj   +1 more source

Higher cyclosporine-A concentration increases the risk of relapse in AML following allogeneic stem cell transplantation from unrelated donors using anti-thymocyte globulin

Scientific Reports, 2023
Cyclosporine-A (CsA) is used to prevent acute graft-versus-host disease (aGvHD). European Society for Blood and Marrow transplantation (EBMT) recommends a CsA target serum concentration of 200–300 µg/L during the first month after allogeneic ...
Mikael Lisak, Malin Nicklasson, Robert Palmason, Stina Wichert, Cecila Isaksson, Per-Ola Andersson, Jan-Erik Johansson, Stig Lenhoff, Mats Brune, Markus Hansson   +9 more
doaj   +1 more source

Direct Oral Anticoagulant removal by a DOAC filter: Impact on lupus anticoagulant testing – Evaluation on spiked and patient samples

Research and Practice in Thrombosis and Haemostasis, 2022
Background DOAC Filter (DF) is a new device to overcome interference in lupus anticoagulant (LAC) testing by direct oral anticoagulants (DOACs). Objectives We evaluated DOAC removal from plasma and elimination of DOAC interference in LAC testing by DF ...
Eleni A. Linskens, Pieter De Kesel, Katrien M. J. Devreese   +2 more
doaj   +1 more source

Coagulation and non‐coagulation effects of thrombin [PDF]

Journal of Thrombosis and Haemostasis, 2016
Thrombin is a multifunctional serine protease produced from prothrombin, and is a key regulator in hemostatic and non-hemostatic processes. It is the main effector protease in primary hemostasis by activating platelets, and plays a key role in secondary hemostasis.
Henri M. H. Spronk, Jelle J. Posthuma, Jens Posma   +2 more
openaire   +3 more sources

Heparin-induced thrombocytopenia and COVID-19

Hematology Reports, 2021
Heparin-induced thrombocytopenia (HIT) has not been included as a possible cause of thrombocytopenia in Coronavirus Disease 2019 (COVID-19) patients. We report a case of HIT in a patient with COVID-19 treated with heparin.
Michelangelo Sartori, Benilde Cosmi
doaj   +1 more source

Application of the thrombin generation assay in patients with antiphospholipid syndrome: A systematic review of the literature

Frontiers in Cardiovascular Medicine, 2023
BackgroundThe antiphospholipid syndrome (APS) is classified by the presence of antiphospholipid antibodies (aPL) and thrombotic and/or adverse obstetric outcomes. The diagnosis and risk assessment of APS is challenging.
Rachel Gehlen, Rachel Gehlen, Arne Vandevelde, Arne Vandevelde, Bas de Laat, Bas de Laat, Katrien M. J. Devreese, Katrien M. J. Devreese   +7 more
doaj   +1 more source

Semi-automated thrombin dynamics applying the ST Genesia thrombin generation assay

Frontiers in Cardiovascular Medicine, 2022
BackgroundThe haemostatic balance is an equilibrium of pro- and anticoagulant factors that work synergistically to prevent bleeding and thrombosis.
Audrey Carlo, Qiuting Yan, Qiuting Yan, Hugo Ten Cate, Romy De Laat-Kremers, Romy De Laat-Kremers, Bas De Laat, Bas De Laat, Marisa Ninivaggi   +8 more
doaj   +1 more source

Coagulation and coagulation signalling in fibrosis

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2013
Following tissue injury, a complex and coordinated wound healing response comprising coagulation, inflammation, fibroproliferation and tissue remodelling has evolved to nullify the impact of the original insult and reinstate the normal physiological function of the affected organ.
Paul F. Mercer, Rachel C. Chambers
openaire   +3 more sources