Results 21 to 30 of about 508,637 (297)

Coagulation and coagulation signalling in fibrosis

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2013
Following tissue injury, a complex and coordinated wound healing response comprising coagulation, inflammation, fibroproliferation and tissue remodelling has evolved to nullify the impact of the original insult and reinstate the normal physiological function of the affected organ.
Mercer, Paul F., Chambers, Rachel C.
openaire   +2 more sources

Hermansky-Pudlak syndrome subtype 5 (HPS-5) novel mutation in a 65 year-old with oculocutaneous hypopigmentation and mild bleeding diathesis: The importance of recognizing a subtle phenotype

Platelets, 2018
Hermansky-Pudlak syndrome (HPS) − characterized by the distinct clinical phenotypes of both oculocutaneous albinism and mild bleeding diathesis–is caused by mutations in genes that have crucial roles in the assembly of cellular organelles (skin ...
Juliana Perez Botero, Dong Chen, Julie A. Majerus, Lea M. Coon, Rong He, Deepti M. Warad, Rajiv K. Pruthi, William L. Nichols   +7 more
doaj   +1 more source

Semi-automated thrombin dynamics applying the ST Genesia thrombin generation assay

Frontiers in Cardiovascular Medicine, 2022
BackgroundThe haemostatic balance is an equilibrium of pro- and anticoagulant factors that work synergistically to prevent bleeding and thrombosis.
Audrey Carlo, Qiuting Yan, Qiuting Yan, Hugo Ten Cate, Romy De Laat-Kremers, Romy De Laat-Kremers, Bas De Laat, Bas De Laat, Marisa Ninivaggi   +8 more
doaj   +1 more source

The effect of unfractionated heparin, enoxaparin, and danaparoid on lupus anticoagulant testing: Can activated carbon eliminate false‐positive results?

Research and Practice in Thrombosis and Haemostasis, 2020
Background Heparins and heparinoids interfere with functional clotting assays used for lupus anticoagulant (LAC) detection. However, current guidelines for LAC testing do not provide clear guidance on this matter.
Pieter M.M. De Kesel, Katrien M.J. Devreese   +1 more
doaj   +1 more source

The Role of Cytokines in Activation of Coagulation and Fibrinolysis in Dengue Shock Syndrome [PDF]

, 2002
In a prospective clinical study of 50 patients with Dengue Shock Syndrome (DSS), we investigated the association of tumor necrosis factor- (TNF-), interleukin-1 (IL-1), IL-1 receptor antagonist (IL-1Ra), and IL-6 with activation markers of coagulation
Cate, Hugo ten, Djokomoeljanto, Robert J., Gorp , Eric C.M. van, Dolmans, Wil M.V., Hack, C. Erik, Suharti, Catharina, Meer, Jos W.M. van der, Setiati , Tatty E.   +7 more
core   +2 more sources

Viscoelastic Testing in Liver Disease

Annals of Hepatology, 2018
Long thought to be hypocoagulable, new evidence suggests cirrhosis patients have “rebalanced” coagulation in the setting of decreased synthesis of both pro- and anti-coagulant factors. Traditional testing like PT/INR reflects only the decreased synthesis
Jessica P.E. Davis, Patrick G. Northup, Stephen H. Caldwell, Nicolas M. Intagliata   +3 more
doaj   +1 more source

Assessing the individual roles of FII, FV, and FX activity in the thrombin generation process

Frontiers in Cardiovascular Medicine, 2022
Thrombin generation (TG) is known as a physiological approach to assess the hemostatic function. Although it correlates well with thrombosis and bleeding, in the current setup it is not sensitive to the effects of fluctuations in single coagulation ...
Cuicui Bai, Cuicui Bai, Joke Konings, Joke Konings, Marisa Ninivaggi, Marcus Lancé, Bas de Laat, Bas de Laat, Romy de Laat-Kremers   +8 more
doaj   +1 more source

The central limit theorem for the Smoluchovski coagulation model [PDF]

, 2010
The general model of coagulation is considered. For basic classes of unbounded coagulation kernels the central limit theorem (CLT) is obtained for the fluctuations around the dynamic law of large numbers (LLN) described by the Smoluchovski equation.
Kolokoltsov, V. N. (Vasiliĭ Nikitich)
core   +1 more source

Synergistic Effect of Bypassing Agents and Sequence Identical Analogue of Emicizumab and Fibrin Clot Structure in the In Vitro Model of Hemophilia A

TH Open, 2020
Development of inhibitors to factor VIII (FVIII) occurs in approximately 30% of severe hemophilia A (HA) patients. These patients are treated with bypassing agents (activated prothrombin complex concentrate [aPCC] and recombinant activated FVII-rFVIIa ...
Yanan Zong, Aleksandra Antovic, Nida Mahmoud Hourani Soutari, Jovan Antovic, Iva Pruner   +4 more
doaj   +1 more source

Failure of Fondaparinux in Autoimmune Heparin-Induced Thrombocytopenia

TH Open, 2020
Heparin-induced thrombocytopenia (HIT) is an immune adverse reaction to heparin that is associated with life-threatening thrombotic complications.
Michelangelo Sartori, Benilde Cosmi
doaj   +1 more source