Results 301 to 310 of about 928,460 (400)

Targeting Decidual CD16+ Immune Cells with Exosome‐Based Glucocorticoid Nanoparticles for Miscarriage

open access: yesAdvanced Science, EarlyView.
Exosome‐based nanoparticles (GC‐Exo‐CD16Ab) are designed to deliver glucocorticoids (GC) specifically to decidual CD16+ NK cells and macrophages. This targeted delivery effectively suppresses the cytotoxicity of decidual NK cells, inhibits M1 macrophage polarization, and modulates the decidual microenvironment.
Linlin Wang   +17 more
wiley   +1 more source

Effects of storage time and temperature on coagulation factor and natural anticoagulant activities in healthy individuals. [PDF]

open access: yesSci Rep
Nakanishi R   +7 more
europepmc   +1 more source

T‐Cell‐Dependent Bispecific IgGs Protect Aged Mice From Lethal SARS‐CoV‐2 Infection

open access: yesAdvanced Science, Volume 12, Issue 15, April 17, 2025.
This study describes the development of spike‐targeting T‐cell‐dependent bispecific full‐length human immunoglobulin Gs with enhanced efficacy in the treatment of COVID‐19. The significance of T‐cell‐based immunity during infection is highlighted. These results have significant implications for better clinical effectiveness of therapies for COVID‐19 ...
Wenyan Fu   +8 more
wiley   +1 more source

Muco‐Penetrating Lipid Nanoparticles Having a Liquid Core for Enhanced Intranasal mRNA Delivery

open access: yesAdvanced Science, Volume 12, Issue 11, March 20, 2025.
Muco‐penetrating, ionizable lipid‐incorporated liquid lipid nanoparticles (iLLNs) with tunable pKa values are designed for enhanced intranasal mRNA delivery. The top candidate iLLN‐2/mRNA complexes demonstrate superior transgene expression in the nasal cavity and antigen‐specific mucosal immunity in mice over the benchmark mRNA‐lipid nanoparticles ...
Nipuni Maniyamgama   +9 more
wiley   +1 more source

Scale‐Up of Human Amniotic Epithelial Cells Through Regulation of Epithelial‐Mesenchymal Plasticity Under Defined Conditions

open access: yesAdvanced Science, Volume 12, Issue 11, March 20, 2025.
Freshly isolated human amniotic epithelial cells (hAECs) from full‐term amniotic membranes include mature epithelial cells as well as cells in a senescent state. During in vitro culture, hAECs undergo epithelial‐mesenchymal transition (EMT) and enter a partial epithelial‐mesenchymal transition (pEMT) state (E/M hybrid) resembling early developmental ...
Wangping Hao   +12 more
wiley   +1 more source

Fatal Crossroads: D-penicillamine and Disseminated Intravascular Coagulation in Wilson's Disease. [PDF]

open access: yesCureus
Mando R   +7 more
europepmc   +1 more source

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