Results 41 to 50 of about 689,025 (351)

Identification of functional and diverse circulating cancer‐associated fibroblasts in metastatic castration‐naïve prostate cancer patients

Molecular Oncology, EarlyView.
Cancer‐associated fibroblasts (CAFs) promote cancer growth, invasion (metastasis), and drug resistance. Here, we identified functional and diverse circulating CAFs (cCAFs) in patients with metastatic prostate cancer (mPCa). cCAFs were found in higher numbers and were functional and diverse in mPCa patients versus healthy individuals, suggesting their ...
Richell Booijink, Leon W. M. M. Terstappen, Eshwari Dathathri, Khrystany Isebia, Jaco Kraan, John Martens, Ruchi Bansal   +6 more
wiley   +1 more source

Coagulation for the clinician.

South African journal of surgery. Suid-Afrikaanse tydskrif vir chirurgie, 2006
The integrity of the circulation is maintained through the provision of a rapid, potent, but tightly localised coagulation response to vascular damage. There is, however, one extraordinary problem in the regulation of haemostasis – blood flows. Normal haemostasis is the ability of the haemostatic system to control activation of clot formation and clot
openaire   +5 more sources

Translation and Cultural Adaptation of the ISTH-Bleeding Assessment Tool to European Portuguese

Acta Médica Portuguesa
Introduction: A distinctive bleeding history is the first diagnostic stage of congenital hemorrhagic diseases. Furthermore, since it is in fact an assessment of the patient’s phenotype, it is not a (mere) complementary diagnostic method or test - it is ...
Diana Carneiro-Leão, Sofia Teixeira, Rita Queirós Pereira, Teresa Mota, Manuela Lopes, Susana Nobre-Fernandes, Fernando Araújo   +6 more
doaj   +1 more source

Mass-conserving weak solutions to Oort-Hulst-Safronov coagulation equation with singular rates [PDF]

arXiv, 2020
Existence of global weak solutions to the continuous Oort-Hulst-Safronov (OHS) coagulation equation is investigated for coagulation kernels capturing a singularity near zero and growing linearly at infinity. The proof mainly relies on a relation, between classical Smoluchowski coagulation equation (SCE) and OHS coagulation equation, which is introduced
arxiv  

Uniqueness of measure solutions for multi-component coagulation equations [PDF]

arXiv, 2023
We prove uniqueness of measure solutions for a multi-component version of Smoluchowski's coagulation equation. The result is valid for a broad range of coagulation kernels and allows to include a source term. The classical coagulation equation is also covered as a special case.
arxiv  

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

Spatial coagulation with bounded coagulation rate [PDF]

Journal of Evolution Equations, 2011
v2, revised and polished version; 11 pages.
openaire   +3 more sources

Increased BMI and Blood Lipids Are Associated With a Hypercoagulable State in the Moli-sani Cohort

Frontiers in Cardiovascular Medicine, 2022
The coagulation system can be assessed by the thrombin generation (TG) assay, and increased TG peak height, endogenous thrombin potential (ETP), and velocity index are associated with an increased risk of thrombosis. Obesity had been reported to increase
Romy de Laat-Kremers, Augusto Di Castelnuovo, Lisa van der Vorm, Simona Costanzo, Marisa Ninivaggi, Chiara Cerletti, Dana Huskens, Dana Huskens, Amalia De Curtis, Alessandro Gialluisi, Alessandro Gialluisi, Cuicui Bai, Cuicui Bai, Giovanni de Gaetano, Dongmei Yin, Maria Benedetta Donati, Bas de Laat, Bas de Laat, Bas de Laat, Licia Iacoviello, Licia Iacoviello, The Moli-sani Investigators   +21 more
doaj   +1 more source

Development of 4T1 breast cancer mouse model system for preclinical carbonic anhydrase IX studies

FEBS Open Bio, EarlyView.
Carbonic anhydrase IX (CAIX) is a well‐recognised therapeutic target and prognostic biomarker in cancer. We developed and characterised a robust murine breast cancer model system that is suitable for CAIX studies in vitro and in vivo—it comprises both CAIX‐positive and CAIX‐negative controls and provides a solid platform for the comprehensive ...
Zane Kalniņa, Ilva Liekniņa, Svetlana Koteloviča, Ramona Petrovska, Gediminas Žvinys, Agne Petrosiute, Asta Zubrienė, Matīss Toms Laugalis, Vendija Skeltona, Juris Jansons, Madara Kreishmane, Edita Čapkauskaitė, Daumantas Matulis, Kaspars Tārs   +13 more
wiley   +1 more source