Results 91 to 100 of about 57,159 (288)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Transcriptome analysis of a new peanut seed coat mutant for the physiological regulatory mechanism involved in seed coat cracking and pigmentation

Frontiers in Plant Science, 2016
Seed-coat cracking and undesirable color of seed coat highly affects external appearance and commercial value of peanuts (Arachis hypogaea L.). With an objective to find genetic solution to the above problems, a peanut mutant with cracking and brown ...
Liyun Wan, Bei Li, Manish Kumar Pandey, Yanshan Wu, Lei Yong, Liying Yan, Xiaofeng Dai, Huifang Jiang, Wei Guo, Juncheng Zhang, Rajeev K Varshney, Rajeev K Varshney, Boshou Liao   +12 more
doaj   +1 more source

Genome-wide association analysis for known color coat loci and racing performance.

, 2019
Manhattan plot for (a) Chestnut coat color, (b) gray coat color, and (c) racing performance.
Hideki Innan (268707), Jeffrey A. Fawcett (83181), Teruaki Tozaki (102292), Takahiro Sakamoto (680396), Fumio Sato (268376), Watal M. Iwasaki (4416970)   +5 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

A noncoding melanophilin gene (MLPH) SNP at the splice donor of exon 1 represents a candidate causal mutation for coat color dilution in dogs [PDF]

, 2007
Coat color dilution in several breeds of dog is characterized by a specific pigmentation phenotype and sometimes accompanied by hair loss and recurrent skin inflammation, the so-called color dilution alopecia or black hair follicular dysplasia.
Günzel-Apel, Anne-Rose, Drögemüller, Cord, Leeb, Tosso, Philipp, Ute, Haase, Bianca   +4 more
core   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Comparison of Growth Traits of Male Bali Cattle (Bos javanicus) with Different Adult Coat Colors

Tropical Animal Science Journal
Bali cattle have a distinct coloration that indicates the sexual dimorphism of adult cattle. However, coat color deviations are found in bulls due to either genetic impurity or inbreeding. Furthermore, information is needed to determine whether there is
I. Suhendro, J. Jakaria, R. Priyanto, W. Manalu, S. Hartono, R. R. Noor   +5 more
doaj   +1 more source

Equine coat color genetics

, 1980
Senior seminar (D.V.M.) -- Cornell University, 1981. Includes bibliographical references (leaves 14-16).The effects of the most important coat color genes in horses are reviewed.
Feldman, Jean F.
core  

Genomic regions associated with coat color in Gir cattle

Indicine cattle breeds are adapted to the tropical climate and their coat plays an important role in this process. Coat color influences thermoregulation and the adhesion of ectoparasites and may be associated with productive and reproductive traits ...
Senes, Beatriz Bastos, Alves, Jackeline Santos, Feitosa, Fabieli Loise Braga, Senes, Beatriz Bastos, Alves, Jackeline Santos, Maciel, Silel Vinicius Simões Andrade, Costa, Raphael Bermal, Oliveira, Ingrid Pereira Pinto, Vasconcelos Silva, Josineudson Augusto II, de Camargo, Gregório Miguel Ferreira, Costa, Raphael Bermal, Camargo, Gregorio, Maciel, Silel Vinicius Simões Andrade, Silva, Josineudson Augusto I. I. de Vasconcelos [UNESP]   +13 more
core   +1 more source