Results 71 to 80 of about 1,533,791 (361)
SensorsBearings are critical components whose failures in industrial machinery can lead to catastrophic breakdowns and costly downtime; yet, accurate early-stage diagnosis remains challenging due to the non-stationary, nonlinear nature of vibration signals and ...
Shouda Wang +3 more
doaj +1 more source
Broadband optical radiation detector [PDF]
, 1981 A method and apparatus for detecting optical radiation by optically monitoring temperature changes in a microvolume caused by absorption of the optical radiation to be detected is described.
Gupta, A., Hong, S. D., Moacanin, J.
core +1 more source
Coating and Pharmacokinetic Evaluation of Air Spray Coated Drug Coated Balloons [PDF]
Cardiovascular Engineering and Technology, 2018 Drug coated balloons (DCB) are becoming the standard-care treatment for peripheral arterial disease (PAD). DCB use excipients to transfer and retain anti-proliferative drugs, such as paclitaxel. Excipients thus play a vital role in the design and function of DCB, however methods to coat balloons with excipients and anti-proliferative drugs remain ...
Emily A. Turner +4 more
openaire +2 more sources
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Development and Examination of Coated Coronary Stents [PDF]
, 2007 The aim of this study is to show the developments carried out by us with coated stents, expansion properties, furthermore the failures of the coatings. The coating was examined before and after expansion, paying special attention to the curves.
Bognár, Eszter +3 more
core
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
A global coating quality model for top-spray fluidized beds: spray sub model [PDF]
, 2010 Fluidized beds are amongst others used in industrial applications for coating particles. Little research has been performed in developing a quality model for a coating process.
Dewettinck, Koen +3 more
core +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source