Results 51 to 60 of about 1,533,791 (361)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Design and evaluation of multilayer Yb4Hf3O12-based T/EBCs with enhanced thermal stability for high-temperature applications

Journal of Advanced Ceramics
Thermal/environmental barrier coatings (T/EBCs) systems are regarded as potential solutions to address the degradation challenges of ceramic matrix composites (CMCs) under extreme temperatures in aeroengine applications.
Yiming Wu, Du Hong, Xin Zhong, Dong Fan, Liping Huang, Yaran Niu, Xuebin Zheng   +6 more
doaj   +1 more source

Mixed polyvalent-monovalent metal coating for carbon-graphite fibers [PDF]

, 1982
An improved coating of gasification catalyst for carbon-graphite fibers is provided comprising a mixture of a polyvalent metal such as calcium and a monovalent metal such as lithium.
Harper-Tervet, J., Humphrey, M. F., Tervet, F. W.   +2 more
core   +1 more source

Structure and wear mechanisms of nano-structured TiAlCN/VCN multilayer coatings [PDF]

, 2007
Dry sliding wear of transition metal nitride coatings usually results in a dense and strongly adhered tribofilm on the worn surface. This paper presents detailed electron microscopy and Raman spectroscopy characterizations of the microstructure, a newly ...
Ajayi, Barshilia, Biswas, Constable, Donnet, Ehiasarian, Erdemir, Hovsepian, Hovsepian, Jamal, Lahres, Luo, Luo, Luo, Luo, Luo, Münz   +16 more
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Microstructure and Mechanical Properties of Gas Tungsten Arc Welded High Manganese Steel Sheet

Metals, 2019
This study investigated microstructure and mechanical properties of high manganese steel sheet fabricated by gas tungsten arc welding (GTAW). The weld zone showed longitudinal coarse grains due to the coalescence of columnar dendrites grown into the ...
Geon-Woo Park, Haeju Jo, Minha Park, Sunmi Shin, Won-Seok Ko, Nokeun Park, Byung-Jun Kim, Yong-Sik Ahn, Jong Bae Jeon   +8 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Surface Charge Effects for the Hydrogen Evolution Reaction on Pt(111) Using a Modified Grand-Canonical Potential Kinetics Method

Molecules
Surface charges of catalysts have important influences on the thermodynamics and kinetics of electrochemical reactions. Herein, we develop a modified version of the grand-canonical potential kinetics (GCP-K) method based on density functional theory (DFT)
Shaoyu Kong, Min Ouyang, Yi An, Wei Cao, Xiaobo Chen   +4 more
doaj   +1 more source

Fabrication of micro-/nano-structured superhydrophobic ceramic coating with reversible wettability via a novel solution precursor vacuum plasma spray process

Materials & Design, 2018
A novel plasma spray process, solution precursor vacuum plasma spray, was developed and used to fabricate superhydrophobic ceramic coatings. By injecting Yb(NO3)3 solution into a plasma jet operated at low pressure, a crystalline Yb2O3 coating was ...
Pengyun Xu, Thomas W. Coyle, Larry Pershin, Javad Mostaghimi   +3 more
doaj   +1 more source

Chlorhexidine-filled porous ceramic coating fabricated by the aerosol deposition method for immediate and long-term enveloped virus inactivation

Journal of Asian Ceramic Societies, 2022
We developed an antiviral ceramic coating for immediate and long-term enveloped virus inactivation. The coating consisted of a porous ceramic coating fabricated by aerosol deposition and filled with chlorhexidine (CHX).
Taku Goto, Yoichi Yamada, Takeji Ueda, Sumiko Shiota, Mitsugu Sohma, Jun Akedo   +5 more
doaj   +1 more source