Results 31 to 40 of about 557,202 (265)
Molecular Oncology, Volume 20, Issue 6, Page 1626-1642, June 2026.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Analysis of the effect of bending, fatigue, erosion-corrosion and tensile stresses on HVOF coating of metallic surfaces [PDF]
, 2006 The aim of the present study was to evaluate the bending, fatigue, tensile stresses and erosion-coiTosion characteristics o f HVOF thermally sprayed Inconel-625 powder coatings when deposited on three different metallic surfaces: (a) plain stainless ...
Al Fadhli, Hussain
core
Thermoviscous Coating and Rimming Flow
, 2012 A comprehensive description is obtained of steady thermoviscous (i.e. with temperature-dependent viscosity) coating and rimming flow on a uniformly rotating horizontal cylinder that is uniformly hotter or colder than the surrounding atmosphere.
Wilson, Stephen +5 more
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, Volume 20, Issue 6, Page 1453-1472, June 2026.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Study into mechanical and electrochemical properties of coating deposits and welded-coated components using the HVOF (High Velocity Oxy-Fuel) process. [PDF]
, 2007 The present study examines the metallurgical, mechanical and corrosion properties of High Velocity Oxy-Fuel (HVOF) thermal spray coatings of Inconel 625 powders on plain and welded surfaces of mild carbon and stainless steel (304).
Boudi, Adnan Abdullatif
core
Asymptotic and numerical analysis of a simple model for blade coating
, 2008 Motivated by the industrial process of blade coating, the two-dimensional flow of a thin film of Newtonian fluid on a horizontal substrate moving parallel to itself with constant speed under a fixed blade of finite length in which the flows upstream and ...
Duffy, B.R. +7 more
core +1 more source
Molecular Oncology, Volume 20, Issue 6, Page 1591-1611, June 2026.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Computer model to predict electron beam-physical vapour deposition (EB-PVD) and thermal barrier coating (TBC) deposition on substrates with complex geometry [PDF]
, 2000 For many decades gas turbine engineers have investigated methods to improve engine efficiency further. These methods include advances in the composition and processing of materials, intricate cooling techniques, and the use of protective coatings ...
Pereira, Vitor Emanuel M. Loureiro S.
core
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, Volume 20, Issue 6, Page 1612-1625, June 2026.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source