Results 41 to 50 of about 405,994 (233)

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Design and evaluation of multilayer Yb4Hf3O12-based T/EBCs with enhanced thermal stability for high-temperature applications

Journal of Advanced Ceramics
Thermal/environmental barrier coatings (T/EBCs) systems are regarded as potential solutions to address the degradation challenges of ceramic matrix composites (CMCs) under extreme temperatures in aeroengine applications.
Yiming Wu, Du Hong, Xin Zhong, Dong Fan, Liping Huang, Yaran Niu, Xuebin Zheng   +6 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Microstructure and Mechanical Properties of Gas Tungsten Arc Welded High Manganese Steel Sheet

Metals, 2019
This study investigated microstructure and mechanical properties of high manganese steel sheet fabricated by gas tungsten arc welding (GTAW). The weld zone showed longitudinal coarse grains due to the coalescence of columnar dendrites grown into the ...
Geon-Woo Park, Haeju Jo, Minha Park, Sunmi Shin, Won-Seok Ko, Nokeun Park, Byung-Jun Kim, Yong-Sik Ahn, Jong Bae Jeon   +8 more
doaj   +1 more source

Recent Development of Electrolyte Engineering for Sodium Metal Batteries

Batteries, 2022
Intermittent renewable energy requires a powerful energy storage system to smoothen the relationship between power generation and power consumption. Due to the rapidly rising price of Li resources, the development of Li-ion batteries (LIBs) has been ...
Yingying Ji, Jiabao Li, Jinliang Li
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Chlorhexidine-filled porous ceramic coating fabricated by the aerosol deposition method for immediate and long-term enveloped virus inactivation

Journal of Asian Ceramic Societies, 2022
We developed an antiviral ceramic coating for immediate and long-term enveloped virus inactivation. The coating consisted of a porous ceramic coating fabricated by aerosol deposition and filled with chlorhexidine (CHX).
Taku Goto, Yoichi Yamada, Takeji Ueda, Sumiko Shiota, Mitsugu Sohma, Jun Akedo   +5 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Surface Charge Effects for the Hydrogen Evolution Reaction on Pt(111) Using a Modified Grand-Canonical Potential Kinetics Method

Molecules
Surface charges of catalysts have important influences on the thermodynamics and kinetics of electrochemical reactions. Herein, we develop a modified version of the grand-canonical potential kinetics (GCP-K) method based on density functional theory (DFT)
Shaoyu Kong, Min Ouyang, Yi An, Wei Cao, Xiaobo Chen   +4 more
doaj   +1 more source