Results 111 to 120 of about 51,500 (320)

Lifespan‐Extending Endogenous Metabolites

Aging Cell, Volume 25, Issue 2, February 2026.
Endogenous metabolites act as mediators of longevity by modulating conserved cellular pathways. We summarize mechanistic evidence linking specific metabolites to lifespan and healthspan benefits across model systems, with discussion of clinical evidence, translational opportunities, and remaining knowledge gaps.
Yizhou Jiang, Jing‐Dong J. Han
wiley   +1 more source

COBALAMIN DEFICIENCY

The Professional Medical Journal, 2016
Objectives: The present study aims to evaluate the serum cobalamin inHelicobacter pylori (H. pylori) infected patients. Study Design: Case control study. Place andDuration: Department of Medicine, Isra University Hospital Hyderabad from March 2013- April2014.
Shumaila Shaikh, Azhar Memon, Muhammad Atif Ata, Haji Khan Khoharo   +3 more
openaire   +2 more sources

Biochemical Testing Promotes Interpretation of Variants of Uncertain Significance in Prenatal Genetic Disease Testing in Four Organic Acidurias

Clinical Genetics, Volume 109, Issue 2, Page 211-217, February 2026.
This review demonstrates how amniotic fluid biochemical testing provides critical phenotypic evidence (ACMG PP4) for reclassifying variants of uncertain significance (VUS) in prenatal organic acidurias. Integrating metabolite analysis with genetic testing enhances diagnostic accuracy and enables informed clinical decisions for affected families ...
Kaili Yin, Qingwei Qi
wiley   +1 more source

Investigating the origins of B12 biosynthesis in the most ancient roots of the tree of life [PDF]

, 2015
Vitamin B12, also known as B12 or cobalamin, is a vital nutrient required across all branches of life, but the ability to synthesize this complex molecule de novo is limited to only a few archaea and bacteria.
Alicea, Edil, Bibis, Stergios S., Celone, Veronica, Jutla, Tripta, Petrus, Amanda K., Swithers, Kristen S.   +5 more
core  

Comparative effectiveness of sodium‐glucose cotransporter‐2 inhibitors and glucagon‐like peptide‐1 receptor agonists for incident dementia: A retrospective multicohort study

Diabetes, Obesity and Metabolism, Volume 28, Issue 2, Page 1443-1452, February 2026.
Abstract Objective This study provides real‐world evidence on the comparative effectiveness of glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) and sodium‐glucose cotransporter‐2 inhibitors (SGLT2i) regarding the risk of incident dementia in adults with type 2 diabetes mellitus (T2DM).
Filippos Anagnostakis, Michail Kokkorakis, Shrihari Nagarajan, Georgia Anastasiou, Christos S. Mantzoros   +4 more
wiley   +1 more source

A double-blind, randomized, comparative study of the use of a combination of uridine triphosphate trisodium, cytidine monophosphate disodium, and hydroxocobalamin, versus isolated treatment with hydroxocobalamin, in patients presenting with compressive neuralgias [PDF]

, 2017
CONTEXT: This paper reports on the results of treatment of compressive neuralgia using a combination of nucleotides (uridine triphosphate trisodium [UTP] and cytidine monophosphate disodium [CMP]) and vitamin B(12).
Buchman, Luiz, Geller, Mauro, Goldberg, Henrique, Goldberg, Stephanie Wrobel, Mezitis, Spyros GE, Mibielli, Marco Antonio, Nunes, Carlos Pereira, Oliveria, Lisa, Rzetelna, Helio, Wajnsztajn, Fernanda   +9 more
core   +2 more sources

A cobalt concentration sensitive Btu-like system facilitates cobalamin uptake in Anabaena sp. PCC 7120

Microbial Cell
Metal homeostasis is central to all forms of life, as metals are es-sential micronutrients with toxic effects at elevated levels. Macromolecular machines facilitate metal uptake into the cells and their intracellular level is regulated by multiple means,
Julia Graf, Leonard Fresenborg, Hans-Michael Seitz, Rafael Pernil, Enrico Schleiff   +4 more
doaj   +1 more source

Cobalamin and folate deficiencies among children in the age group of 12-59 months in India

Biomedical Journal, 2015
Background: Anemia is a major public health problem among children under 5 years of age in India. Cobalamin and folate deficiencies play an important role in the etiology of anemia.
Umesh Kapil, GS Toteja, Ajeet Singh Bhadoria   +2 more
doaj   +1 more source

Accessing the impact of harvest weights of Tenebrio molitor on amino acid digestibility and metabolizable energy in cecectomized laying hens

Journal of the Science of Food and Agriculture, Volume 106, Issue 1, Page 665-674, 15 January 2026.
Abstract BACKGROUND The effects of harvest weights on composition, amino acid (AA) digestibility and metabolizable energy (MEN) of Tenebrio molitor (TM) were investigated using cecectomized laying hens. The partially defatted and dried TM variants comprised median individual frass‐free harvest weights of 60, 80, 100, and 120 mg of larvae, and a pupae ...
Adewunmi Omotoso, Elena Werner, Nils Hautkapp, Markus Rodehutscord, Wolfgang Siegert   +4 more
wiley   +1 more source

Ion torrent-based transcriptional assessment of a Corynebacterium pseudotuberculosis equi strain reveals denaturing high-performance liquid chromatography a promising rRNA depletion method [PDF]

, 2013
Corynebacterium pseudotuberculosis equi is a Gram-positive pathogenic bacterium which affects a variety of hosts. Besides the great economic losses it causes to horse-breeders, this organism is also known to be an important infectious agent to cattle and
Azarani, Azarani, Baird, Barakat, Biberstein, Braverman, Bustin, Chen, Chen, Colbert, Conesa, Efstratiou, Gaspar, Hantke, Jones, Jünemann, Lukashin, Martin, Meldrum, Muto, Nguyen, Nolden, Pacheco, Papp-Wallace, Patel, Paton, Pfaffl, Piddington, Pinho, Pinto, Ramos, Ramos, Richardson, Ruiz, Sambrook, Schulz, Sorek, Spier, Swiercz, Trost, Vliet, Weinberg, Westermann, Wong, Zerbino   +44 more
core   +1 more source