Results 151 to 160 of about 14,134 (199)

Isolation of cobalamin and cobalamin analogs by reverse affinity chromatography

Analytical Biochemistry, 1978
Abstract A method is described for adsorbing cobalamin and a number of cobalamin analogs from bacterial lysates to columns of Sepharose containing a covalently bound cobalamin-binding protein. After multiple elutions to remove impurities, cobalamin and cobalamin analogs are eluted in highly purified form with liquified phenol with recoveries in ...
Robert H. Allen, J. Fred Kolhouse
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Cobalamin and normal prions: A new horizon for cobalamin neurotrophism

Biochimie, 2013
It is known that cobalamin (Cbl) deficiency damages myelin by increasing tumor necrosis factor (TNF)-α and decreasing epidermal growth factor (EGF) levels in rat central nervous system (CNS), and affects the peripheral nervous system (PNS) morphologically and functionally.
G. Scalabrino, D. Veber
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Performance of the Serum Cobalamin Assay for Diagnosis of Cobalamin Deficiency

The American Journal of the Medical Sciences, 1994
The authors' objective, with this study, was to determine the use in routine clinical practice of the cobalamin serum assay in evaluating patients suspected of having cobalamin deficiency. The design was a prospective observational study of a diagnostic test compared with a criterion gold standard.
David B. Matchar, John R. Feussner, John R. Feussner, David S. Millington, Douglas C McCrory, Douglas C McCrory   +5 more
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Cobalamin and cobalamin-binding capacity in human milk

Nutrition Research, 1994
Abstract Information on variability of cobalamin and its binding protein concentrations in human milk is scarce. We investigated their relationship and longitudinal changes up to the third month of lactation, and their inter and intraindividual variability within the day, between breasts and within the feed in samples from nine healthy lactating ...
Fátima Lúcia de Carvalho Sardinha, Nadia M.F. Trugo   +1 more
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Membrane transport of cobalamin

2022
A wide variety of organisms encode cobalamin-dependent enzymes catalyzing essential metabolic reactions, but the cofactor cobalamin (vitamin B12) is only synthesized by a subset of bacteria and archaea. The biosynthesis of cobalamin is complex and energetically costly, making cobalamin variants and precursors metabolically valuable.
Nijland, Mark, Martínez Felices, Jose M., Slotboom, Dirk J., Thangaratnarajah, Chancievan   +3 more
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Cobalamin Deficiency

2011
Cobalamin (Cbl, vitamin B12) consists of a corrinoid structure with cobalt in the centre of the molecule. Neither humans nor animals are able to synthesize this vitamin. Foods of animal source are the only natural source of cobalamin in human diet.
Wolfgang, Herrmann, Rima, Obeid
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Cimetidine and malabsorption of cobalamin

Digestive Diseases and Sciences, 1982
Cimetidine in a dosage of 1000 mg daily (200 mg t.i.d. plus 400 mg nocte) reduced the absorption of protein-bound cobalamin by peptic ulcer patients and normal subjects. However, cimetidine in a dosage of 400 mg at night had no significant effect, nor did tripotassium dicitratobismuthate in a dosage of 480 mg daily. Thus long-term administration of 400
M. T. Pheils, F. A. Bathur, G. G. Crane, R. S. Hilmer, A.M. Streeter, K. J. Goulston   +5 more
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High-pressure liquid chromatography of cobalamins and cobalamin analogs

Analytical Biochemistry, 1982
Abstract High-pressure liquid chromatography has been used to separate, identify, and quantitate 37 different cyanocobalamin analogs, including the most commonly occurring analogs that result from bacterial synthesis. This technique has also been used to simultaneously separate, identify, and quantitate five naturally occurring cobalamins that differ
Kenneth C. Van Horne, Mitchell Binder, J. Fred Kolhouse, Robert H. Allen   +3 more
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Cobalamin Absorption and Acquired Forms of Cobalamin Malabsorption

1989
Cobalamin (Cbl), or vitamin B12, cannot be synthesized in the human body, and the only possible source for this vitamin is thus the diet. Daily requirements are 1-3 µg [31]. Dietary sources are primarily animal proteins. Liver, mammalian kidneys, and seafood are especially rich in this vitamin. Meat, fish, milk, and dairy foods also contain vitamin B12,
D. Cattan, J. Belaïche
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Cobalamin and the Nervous System

New England Journal of Medicine, 1988
To the stalwart little band of investigators of vitamin B12 — now more rationally termed cobalamin — there is comfort in knowing that the stream of important scientific problems will never end.
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