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High-pressure liquid chromatography of cobalamins and cobalamin analogs
Analytical Biochemistry, 1982Abstract High-pressure liquid chromatography has been used to separate, identify, and quantitate 37 different cyanocobalamin analogs, including the most commonly occurring analogs that result from bacterial synthesis. This technique has also been used to simultaneously separate, identify, and quantitate five naturally occurring cobalamins that differ
M, Binder +3 more
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Subclinical cobalamin deficiency
Current Opinion in Gastroenterology, 2012This review focuses on recent developments and controversies in the diagnosis, consequences, and management of subclinical cobalamin deficiency (SCCD), which affects many elderly persons.Diagnosis of SCCD depends exclusively on biochemical tests whose individual limitations suggest that combinations of tests are needed, especially in epidemiologic ...
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Cobalamin-Dependent Methyltransferases
Accounts of Chemical Research, 2001Cobalamin cofactors play critical roles in radical-catalyzed rearrangements and in methyl transfers. This Account focuses on the role of methylcobalamin and its structural homologues, the methylcorrinoids, as intermediaries in methyl transfer reactions, and particularly on the reaction catalyzed by cobalamin-dependent methionine synthase.
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[Cobalamin deficiency despite normal serum cobalamins].
Ugeskrift for laeger, 1992In a man aged 77 years with normal concentrations of cobalamins in the serum, the concentration of methylmalonic acid in the serum was raised (2,920 nmol/l; 50-370 nmol/l). (The serum cobalamin concentrations were measured both by an old R-binder method (400 pmol/l; reference interval 200-800 pmol/l) and by a more recent S-binder method (164 pmol/l; 95-
K, Rasmussen, K O, Pedersen, S, Sillesen
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Neuropsychiatric Disorders Caused by Cobalamin Deficiency in the Absence of Anemia or Macrocytosis
New England Journal of Medicine, 1988Sally P Stabler
exaly