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Current Concepts in Cobalamin Deficiency

Annual Review of Medicine, 2000
The application of sensitive metabolic tests, such as the deoxyuridine suppression test and measurement of homocysteine and methylmalonic acid, to cobalamin status has identified the entity of mild, preclinical cobalamin deficiency.
Ralph Carmel
exaly   +2 more sources

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Effective Treatment of Cobalamin Deficiency With Oral Cobalamin

Blood, 1998
Because cobalamin deficiency is routinely treated with parenteral cobalamin, we investigated the efficacy of oral therapy. We randomly assigned 38 newly diagnosed cobalamin deficient patients to receive cyanocobalamin as either 1 mg intramuscularly on days 1, 3, 7, 10, 14, 21, 30, 60, and 90 or 2 mg orally on a daily basis for 120 days.
Robert H Allen, Sally P Stäbler, J Lindenbaum   +2 more
exaly   +3 more sources

Cobalamin

Critical Reviews in Clinical Laboratory Sciences, 1996
Cobalamin (vitamin B12) is an essential nutrient derived exclusively from bacterial sources. It is an essential cofactor for three known enzymatic reactions. Untreated deficiency, caused by either the autoimmune disease pernicious anemia or nutritional lack, results in a macrocytic anemia and/or subacute combined degeneration of the spinal cord and is ...
H. V. Markle, D. C. Greenway
openaire   +2 more sources

Biliary Excretion of Cobalamin and Cobalamin Analogues in Man

Digestion, 2009
Using dialysis, gel filtration, isoelectrofocusing and radioaffinity assay, we studied the unsaturated and saturated binders of bile and the biliary concentration of cobalamin (Cbl) and Cbl analogues compared to the corresponding serum concentrations in 7 choledochodomized patients.
J L, Guéant, B, Monin, P, Boissel, P, Gaucher, J P, Nicolas   +4 more
openaire   +2 more sources

Cobalamin Deficiency

2011
Cobalamin (Cbl, vitamin B12) consists of a corrinoid structure with cobalt in the centre of the molecule. Neither humans nor animals are able to synthesize this vitamin. Foods of animal source are the only natural source of cobalamin in human diet.
Wolfgang, Herrmann, Rima, Obeid
openaire   +2 more sources

Performance of the Serum Cobalamin Assay for Diagnosis of Cobalamin Deficiency

American Journal of the Medical Sciences, 1994
The authors' objective, with this study, was to determine the use in routine clinical practice of the cobalamin serum assay in evaluating patients suspected of having cobalamin deficiency. The design was a prospective observational study of a diagnostic test compared with a criterion gold standard.
David B Matchar, Douglas C Mccrory, David S Millington   +2 more
exaly   +3 more sources

Isolation of cobalamin and cobalamin analogs by reverse affinity chromatography

Analytical Biochemistry, 1978
Abstract A method is described for adsorbing cobalamin and a number of cobalamin analogs from bacterial lysates to columns of Sepharose containing a covalently bound cobalamin-binding protein. After multiple elutions to remove impurities, cobalamin and cobalamin analogs are eluted in highly purified form with liquified phenol with recoveries in ...
J F, Kolhouse, R H, Allen
openaire   +2 more sources

Cobalamin and normal prions: A new horizon for cobalamin neurotrophism

Biochimie, 2013
It is known that cobalamin (Cbl) deficiency damages myelin by increasing tumor necrosis factor (TNF)-α and decreasing epidermal growth factor (EGF) levels in rat central nervous system (CNS), and affects the peripheral nervous system (PNS) morphologically and functionally.
G. Scalabrino, D. Veber
openaire   +3 more sources