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High-pressure liquid chromatography of cobalamins and cobalamin analogs
Analytical Biochemistry, 1982Abstract High-pressure liquid chromatography has been used to separate, identify, and quantitate 37 different cyanocobalamin analogs, including the most commonly occurring analogs that result from bacterial synthesis. This technique has also been used to simultaneously separate, identify, and quantitate five naturally occurring cobalamins that differ
M, Binder +3 more
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Cimetidine and malabsorption of cobalamin
Digestive Diseases and Sciences, 1982Cimetidine in a dosage of 1000 mg daily (200 mg t.i.d. plus 400 mg nocte) reduced the absorption of protein-bound cobalamin by peptic ulcer patients and normal subjects. However, cimetidine in a dosage of 400 mg at night had no significant effect, nor did tripotassium dicitratobismuthate in a dosage of 480 mg daily. Thus long-term administration of 400
A M, Streeter +5 more
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Cobalamin and the Nervous System
New England Journal of Medicine, 1988To the stalwart little band of investigators of vitamin B12 — now more rationally termed cobalamin — there is comfort in knowing that the stream of important scientific problems will never end.
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Nitrous Oxide and the Cobalamins
Clinical Science, 1980Vitamin B12 is able to cleave the anaesthetic gas nitrous oxide and in the process is itself oxidized to an inactive form. This has provided an opportunity for exploring the effect of vitamin B12 deficiency in the experimental animal as well as in man, and hence for unravelling some of the tangled skeins of vitamin B12-folate interrelations.
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Cobalamins and the spectrochemical series
Dalton Transactions, 2008UV-visible-NIR spectra of a variety of cobalamins were run in water and methanol. A broad absorption band (band A) with extinction coefficients of about an order of magnitude less than those of the alphabeta bands was found in the red and NIR regions for Cl-cobalamin (Cl-cbl), Br-cbl, I-cbl, SC(NH(2))(2)-cbl(+) and SeCN-cbl.
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