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Evaluation of laboratory findings indicating pancreatitis in healthy lean, obese, and diabetic cats. [PDF]
J Vet Intern MedJørgensen FK +4 more
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Critical Reviews in Clinical Laboratory Sciences, 1996
Cobalamin (vitamin B12) is an essential nutrient derived exclusively from bacterial sources. It is an essential cofactor for three known enzymatic reactions. Untreated deficiency, caused by either the autoimmune disease pernicious anemia or nutritional lack, results in a macrocytic anemia and/or subacute combined degeneration of the spinal cord and is ...
H. V. Markle, D. C. Greenway
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Cobalamin (vitamin B12) is an essential nutrient derived exclusively from bacterial sources. It is an essential cofactor for three known enzymatic reactions. Untreated deficiency, caused by either the autoimmune disease pernicious anemia or nutritional lack, results in a macrocytic anemia and/or subacute combined degeneration of the spinal cord and is ...
H. V. Markle, D. C. Greenway
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Effective Treatment of Cobalamin Deficiency With Oral Cobalamin
Blood, 1998Because cobalamin deficiency is routinely treated with parenteral cobalamin, we investigated the efficacy of oral therapy. We randomly assigned 38 newly diagnosed cobalamin deficient patients to receive cyanocobalamin as either 1 mg intramuscularly on days 1, 3, 7, 10, 14, 21, 30, 60, and 90 or 2 mg orally on a daily basis for 120 days.
Sally P. Stabler +4 more
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Biliary Excretion of Cobalamin and Cobalamin Analogues in Man
Digestion, 1984Using dialysis, gel filtration, isoelectrofocusing and radioaffinity assay, we studied the unsaturated and saturated binders of bile and the biliary concentration of cobalamin (Cbl) and Cbl analogues compared to the corresponding serum concentrations in 7 choledochodomized patients.
Patrick Boissel +4 more
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The retention of cobalamin by the liver in the cobalamin-deficient rat
Clinical Science, 19851. The effect of cobalamin deficiency on whole body cobalamin content and its turnover was examined in the rat. Quantitative and qualitative changes in hepatic cobalamin were also followed and the effect of deficiency on the turnover of this cobalamin was determined in the isolated perfused liver. 2.
Owens, J.A. +2 more
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Isolation of cobalamin and cobalamin analogs by reverse affinity chromatography
Analytical Biochemistry, 1978Abstract A method is described for adsorbing cobalamin and a number of cobalamin analogs from bacterial lysates to columns of Sepharose containing a covalently bound cobalamin-binding protein. After multiple elutions to remove impurities, cobalamin and cobalamin analogs are eluted in highly purified form with liquified phenol with recoveries in ...
Robert H. Allen, J. Fred Kolhouse
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Cobalamin and normal prions: A new horizon for cobalamin neurotrophism
Biochimie, 2013It is known that cobalamin (Cbl) deficiency damages myelin by increasing tumor necrosis factor (TNF)-α and decreasing epidermal growth factor (EGF) levels in rat central nervous system (CNS), and affects the peripheral nervous system (PNS) morphologically and functionally.
G. Scalabrino, D. Veber
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Performance of the Serum Cobalamin Assay for Diagnosis of Cobalamin Deficiency
The American Journal of the Medical Sciences, 1994The authors' objective, with this study, was to determine the use in routine clinical practice of the cobalamin serum assay in evaluating patients suspected of having cobalamin deficiency. The design was a prospective observational study of a diagnostic test compared with a criterion gold standard.
David B. Matchar +5 more
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Cobalamin and cobalamin-binding capacity in human milk
Nutrition Research, 1994Abstract Information on variability of cobalamin and its binding protein concentrations in human milk is scarce. We investigated their relationship and longitudinal changes up to the third month of lactation, and their inter and intraindividual variability within the day, between breasts and within the feed in samples from nine healthy lactating ...
Fátima Lúcia de Carvalho Sardinha +1 more
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