Results 71 to 80 of about 43,643 (334)

A hidden cause of infertility in hypothyroid patients [PDF]

, 2020
Methylene tetrahydrofolate reductase (MTHFR) gene mutations could be the cause of infertility in hypothyroid patients. Hence, it is worthy to screen for MTHFR gene mutations in infertile hypothyroid females and their partners if infertility persists ...
Ahmed, Soha Magdy, Allam, Magdy Mohamed, Barakat, Sherine Samir, El-Zawawy, Hanaa Tarek, Saleh, Rasha Noureldin M.   +4 more
core   +1 more source

Inherited disorders of cobalamin metabolism disrupt nucleocytoplasmic transport of mRNA through impaired methylation/phosphorylation of ELAVL1/HuR

Nucleic Acids Research, 2018
The molecular mechanisms that underlie the neurological manifestations of patients with inherited diseases of vitamin B12 (cobalamin) metabolism remain to date obscure.
S. Battaglia-Hsu, Rose Ghemrawi, David Coelho, Natacha Dreumont, Pauline Mosca, Sébastien Hergalant, G. Gauchotte, J. M. Sequeira, Mariam Ndiongue, R. Houlgatte, J. Alberto, Rémy Umoret, Aurélie Robert, J. Paoli, M. Jung, E. Quadros, J. Guéant   +16 more
semanticscholar   +1 more source

Severe Vasoplegic Syndrome Treated with Angiotensin II and Hemoadsorption Therapy after Cardiac Surgery

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Vasoplegic syndrome (VS) is a common complication after cardiac surgery with cardiopulmonary bypass (CPB). The main pathophysiology mechanism of VS includes a systemic inflammatory response syndrome due to surgical trauma, release of pro‐inflammatory mediators caused by blood contact with foreign surfaces of heart‐lung machine (pump and tubing)
Matteo Lucchelli, Davide Tommaso Andreis, Mattia Gomarasca, Giovanni Mistraletti   +3 more
wiley   +1 more source

A dodecylamine derivative of cyanocobalamin potently inhibits the activities of cobalamin-dependent methylmalonyl-CoA mutase and methionine synthase of Caenorhabditis elegans

FEBS Open Bio, 2014
In this study, we showed that cyanocobalamin dodecylamine, a ribose 5′-carbamate derivative of cyanocobalamin, was absorbed and accumulated to significant levels by Caenorhabditis elegans and was not further metabolized.
Tomohiro Bito, Yukinori Yabuta, Tsuyoshi Ichiyanagi, Tsuyoshi Kawano, Fumio Watanabe   +4 more
doaj   +1 more source

Relationship between serum cobalamin concentration and endoscopic ileal appearance and histology in dogs with chronic inflammatory enteropathy

Journal of Veterinary Internal Medicine, 2022
Background It has not been determined whether ileal appearance differs among dogs with chronic inflammatory enteropathy (CIE) and different serum concentrations of cobalamin.
Eva M. Pérez‐Merino, Ignacio Cristóbal‐Verdejo, Francisco J. Duque‐Carrasco, Lorena Espadas‐González, Nieves Pastor‐Sirvent, Jesús M. Usón‐Casaús   +5 more
doaj   +1 more source

Transcobalamin C776G genotype modifies the association between vitamin B12 and homocysteine in older Hispanics. [PDF]

, 2010
Background/objectivesA common polymorphism, C776G, in the plasma B12 transport protein transcobalamin (TC), encodes for either proline or arginine at codon 259.
Allen, LH, Garrod, MG, Green, R, Haan, MN, Miller, JW   +4 more
core   +2 more sources

Maternal Serum Cobalamin at 18 Weeks of Pregnancy Predicts Infant Cobalamin Status at 6 Months-A Prospective, Observational Study.

Journal of NutriLife, 2018
Background An adequate maternal cobalamin status is crucial for fetal and infant neurodevelopment. Pregnancy-induced physiologic changes make evaluation of maternal cobalamin status in pregnancy difficult.
Kristin Varsi, P. Ueland, I. Torsvik, A. Bjørke-Monsen   +3 more
semanticscholar   +1 more source

B12‐Cofactor Inactivation by Cobalt to Rhodium Mutation in Methylrhodibalamin: An Antivitamin B12 and Antibiotic

ChemistryEurope, EarlyView.
Replacement of cobalt in the organometallic B12‐cofactor methylcobalamin (MeCbl) by rhodium furnishes a structural mimic with a significantly stronger metal–carbon bond. This synthetically challenging formal metal‐mutation converts the naturally optimized biological methyl‐transfer catalyst MeCbl into a designed antivitamin B12, an inactivated B12 ...
Florian J. Widner, Klaus Wurst, Markus Ruetz, Christoph Kieninger, Christoph Kreutz, Michael D. Paxhia, Evelyne Deery, Martin J. Warren, Bernhard Kräutler   +8 more
wiley   +1 more source

The relationship between exacerbated diabetic peripheral neuropathy and metformin treatment in type 2 diabetes mellitus

Scientific Reports, 2021
Metformin-treated diabetics (MTD) showed a decrease in cobalamin, a rise in homocysteine, and methylmalonic acid, leading to accentuated diabetic peripheral neuropathy (DPN). This study aimed to determine whether or not metformin is a risk factor for DPN.
Manal Mohammed Hashem, Ahmed Esmael, Abdelfattah Kasem Nassar, Mohammed El-Sherif   +3 more
doaj   +1 more source

Human gut Bacteroides capture vitamin B12 via cell surface-exposed lipoproteins. [PDF]

, 2018
Human gut Bacteroides use surface-exposed lipoproteins to bind and metabolize complex polysaccharides. Although vitamins and other nutrients are also essential for commensal fitness, much less is known about how commensal bacteria compete with each other
Barry, Natasha A, Degnan, Patrick H, Folta-Stogniew, Ewa, Goodman, Andrew L, Schofield, Whitman B, Wexler, Aaron G   +5 more
core