Results 51 to 60 of about 6,638 (137)
Cobalamin in the healthy human intestinal tract.
, 2019 Ingested food containing cobalamin enters the stomach. IF is produced in the stomach and binds cobalamin in the small intestine. There, cobalamin–IF complexes are absorbed by host enterocytes in the terminal ileum (indicated by outward arrows in small ...
Carol A. Rowley (6172088) +1 more
core +1 more source
Membrane transport of cobalamin
, 2022 A wide variety of organisms encode cobalamin-dependent enzymes catalyzing essential metabolic reactions, but the cofactor cobalamin (vitamin B12) is only synthesized by a subset of bacteria and archaea.
Mark Nijland +7 more
core +1 more source
Bioavailability through lactic fermentation in millet for combating hidden hunger
Food Biomacromolecules, EarlyView.Millets are nutrient‐rich grains with considerable potential to combat hidden hunger, but the presence of anti‐nutritional factors, can restrict mineral bioavailability. Processing strategies including soaking, germination, cooking, and lactic acid fermentation can reduce the anti‐nutritional factors.
Ajina Anila Sugathan +3 more
wiley +1 more source
Scientific Reports, 2021 Metformin-treated diabetics (MTD) showed a decrease in cobalamin, a rise in homocysteine, and methylmalonic acid, leading to accentuated diabetic peripheral neuropathy (DPN). This study aimed to determine whether or not metformin is a risk factor for DPN.
Manal Mohammed Hashem +3 more
doaj +1 more source
Synthesis of a “Base‐On” Yellow Corrinoid From Vitamin B12
Helvetica Chimica Acta, EarlyView.A rare “base‐on” yellow corrinoid is obtained from vitamin B12 in a concise semi‐synthesis. Structural and spectroscopic characterization identifies 5,6‐dihydroxyaquacobalamin, in which interruption of the corrin π‐system coexists with dimethylbenzimidazole coordination to cobalt(III), providing new insight into the structure and electronic properties ...
Lucas Prieto +2 more
wiley +1 more source
, 1984 To examine possible regulatory roles of liver and kidney in cobalamin metabolism, specific activities of the two cobalamin-dependent enzymes, uptake in vivo of cyano [57Co]cobalamin [( 57Co]CNCbl) and the binding of [57Co]Cbl to intracellular proteins ...
Treston, A.M. +4 more
core +1 more source
JPGN Reports, EarlyView.ABSTRACT Vitamin B12 (cobalamin, Cbl) is an essential micronutrient for DNA synthesis and neurological development. Its deficiency in infants, although infrequent in developed countries, can cause megaloblastic anemia, psychomotor delay, and neurological damage that may become irreversible if not treated early.
Sandra Sala‐Lluch +5 more
wiley +1 more source
Cobalamin binding and cobalamin-dependent enzyme activity in normal and mutant human fibroblasts
, 1978 binding of radioactive cobalamin by normal cultured human fibroblasts grown in medium containing [57Co]-cobalamin. We have also assessed the significance of defects in this binding activity exhibited by two classes ofhuman mutants (cbl C and cbl D) each ...
Ira Mellman +2 more
core +1 more source
More than just anemia: Uncovering celiac disease beneath the surface: A case report
JPGN Reports, EarlyView.Abstract Celiac disease (CD) is an immune‐mediated disorder triggered by gluten in genetically susceptible individuals. Although iron deficiency anemia is a common presentation, other micronutrient deficiencies may occur. We describe a 3.5‐year‐old female whose initial presentation of CD was severe, asymptomatic normocytic anemia secondary to copper ...
Evan Greenhall +3 more
wiley +1 more source
Ligand Binding Characteristics of the Cobalamin Binder from Zebrafish.
, 2012 The zebrafish cobalamin binder (as well as human TC, HC, and IF) was incubated for 18 hours with 57[Co]-cobalamin and increasing concentrations of the unlabeled ligand: cyano-cobalamin (A), dicyano-cobinamide (B) and adenosyl-pseudo-cobalamin (C ...
Eva Greibe (171188) +2 more
core +1 more source