Results 31 to 40 of about 26,570 (248)

De novo cobalamin biosynthesis, transport, and assimilation and cobalamin-mediated regulation of methionine biosynthesis in Mycobacterium smegmatis [PDF]

, 2021
Cobalamin is an essential cofactor in all domains of life, yet its biosynthesis is restricted to some bacteria and archaea. Mycobacterium smegmatis, an environmental saprophyte frequently used as surrogate for the obligate human pathogen M. tuberculosis,
Wiesner, L., Koch, A., Kipkorir, T., Mizrahi, V., Mashabela, G.T., de Wet, T.J., Warner, D.F.   +6 more
core   +2 more sources

Extracellular loops of BtuB facilitate transport of vitamin B12 through the outer membrane of E. coli.

PLoS Computational Biology, 2020
Vitamin B12 (or cobalamin) is an enzymatic cofactor essential both for mammals and bacteria. However, cobalamin can be synthesized only by few microorganisms so most bacteria need to take it up from the environment through the TonB-dependent transport ...
Tomasz Pieńko, Joanna Trylska
doaj   +1 more source

Effect of oral or injectable supplementation with cobalamin in dogs with hypocobalaminemia caused by chronic enteropathy or exocrine pancreatic insufficiency

Journal of Veterinary Internal Medicine, 2022
Background Recent studies have shown similar efficacy of oral supplementation of cobalamin compared to injectable supplementation in dogs, but few prospective, randomized studies have been published.
Chee‐Hoon Chang, Jonathan A. Lidbury, Jan S. Suchodolski, Joerg M. Steiner   +3 more
doaj   +1 more source

Scientific Opinion on Dietary Reference Values for cobalamin (vitamin B12)

EFSA Journal, 2015
Following a request from the European Commission, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) derived Dietary Reference Values (DRVs) for cobalamin (vitamin B12).
EFSA Panel on Dietetic Products, Nutrition, and Allergies (NDA)
doaj   +1 more source

Sinorhizobium meliloti Requires a Cobalamin-Dependent Ribonucleotide Reductase for Symbiosis With Its Plant Host

Molecular Plant-Microbe Interactions, 2010
Vitamin B12 (cobalamin) is a critical cofactor for animals and protists, yet its biosynthesis is limited to prokaryotes. We previously showed that the symbiotic nitrogen-fixing alphaproteobacterium Sinorhizobium meliloti requires cobalamin to establish a
Michiko E. Taga, Graham C. Walker
doaj   +1 more source

Decreased cobalamin sensitivity and biological aging acceleration in the general population

The Journal of Nutrition, Health and Aging
Background: The evidence on the association between cobalamin (Cbl) and aging or relevant outcomes is limited and controversial. We aimed to investigate the relationships between cobalamin intake- and function-related biomarkers and biological aging ...
Fan Tang, Hongbin Qiu, Yan Liu, Junchen Guo, Zheming Huang, Shaohong Fang, Yiying Zhang, Shanjie Wang   +7 more
doaj   +1 more source

Effects of oral cobalamin supplementation on serum cobalamin concentrations in dogs with exocrine pancreatic insufficiency: A pilot study [PDF]

, 2021
The objective of this retrospective study was to evaluate serum cobalamin concentrations before and after oral cobalamin supplementation in dogs with low serum cobalamin concentrations and exocrine pancreatic insufficiency (EPI). Eighteen dogs with serum
Toresson, Linda, Steiner, Joerg M., Spodsberg, Eva, Lidbury, Jonathan, Spillmann, Thomas, Suchodolski, Jan, Olmedal, Gunilla   +6 more
core   +1 more source

Cobalamin and folate status in 6 to 35 months old children presenting with acute diarrhea in Bhaktapur, Nepal.

PLoS ONE, 2014
BackgroundCobalamin and folate are essential micronutrients and are important in DNA and RNA synthesis, cell proliferation, growth, hematopoiesis, and cognitive function.
Manjeswori Ulak, Ram K Chandyo, Ramesh K Adhikari, Pushpa R Sharma, Halvor Sommerfelt, Helga Refsum, Tor A Strand   +6 more
doaj   +1 more source

Prevalence of serum cobalamin and folate deficiency among children aged 6–59 months: A hospital-based cross-sectional study from Northern India

Journal of Family Medicine and Primary Care, 2022
Context: Cobalamin and folate are essential for the synthesis of nucleic acids and in the maintenance of myelin. They are required during the period of the rapid growth of infancy and childhood.
Surbhi Gupta, Partha Haldar, Archana Singh, Sumit Malhotra, Shashi Kant   +4 more
doaj   +1 more source

Transcriptomic and proteomic changes associated with cobalamin-dependent propionate production by the rumen bacterium Xylanibacter ruminicola

mSystems
Xylanibacter ruminicola is an abundant rumen bacterium that produces propionate in a cobalamin (vitamin B12)-dependent manner via the succinate pathway.
Sam C. Mahoney-Kurpe, Nikola Palevich, Dragana Gagic, Patrick J. Biggs, Peter M. Reid, Ianina Altshuler, Phillip B. Pope, Graeme T. Attwood, Christina D. Moon   +8 more
doaj   +1 more source