Results 41 to 50 of about 26,570 (248)

Fat digestibility is reduced in old cats with subnormal cobalamin concentrations

Journal of Nutritional Science, 2014
Fat digestibility is decreased in old cats for unknown reasons. Subclinical gastrointestinal diseases and pancreatic dysfunction, both related to ageing, can affect food digestibility.
Anna Salas, Carmen-Loreto Manuelian, Marta Garganté, Núria Sanchez, Sonia Fernández, Marco Compagnucci, Jose Joaquín Cerón, Isabelle Jeusette, Lluís Vilaseca, Celina Torre   +9 more
doaj   +1 more source

Dynamics and interactions of cobalamin and folate status during advanced aging – a longitudinal study in a community-dwelling cohort with multiple follow-ups

Nutrition Journal, 2020
Background Older people are reported to be prone to imbalances between cobalamin and folate status with possible adverse effects on health. This longitudinal study investigates dynamics and interactions of cobalamin and folate status in a cohort of ...
Alexandra Jungert, Carola Zenke-Philippi, Monika Neuhäuser-Berthold   +2 more
doaj   +1 more source

Genetic testing is necessary for correct diagnosis and treatment in patients with isolated methylmalonic aciduria: a case report

BMC Pediatrics, 2021
Background Isolated methylmalonic aciduria can be caused by pathogenic mutations in the gene for methylmalonyl-CoA mutase or in the genes encoding enzymes involved in the intracellular metabolism of cobalamin.
Katarína Brennerová, Martina Škopková, Mária Ostrožlíková, Jana Šaligová, Juraj Staník, Vladimír Bzdúch, Daniela Gašperíková   +6 more
doaj   +1 more source

Cobalamin-Dependent Apparent Intramolecular Methyl Transfer for Biocatalytic Constitutional Isomerization of Catechol Monomethyl Ethers

, 2019
Isomerization is a fundamental reaction in chemistry. However, isomerization of phenyl methyl ethers has not been described yet. Using a cobalamin-dependent methyl transferase, a reversible shuttle concept was investigated for isomerization of catechol ...
Wolfgang Kroutil (1279629), Ferdinand Zepeck, Katharina Hiebler (1674478), Sarah Bierbaumer, Ferdinand Zepeck (1479463), Katharina Hiebler, Wolfgang Kroutil, Wolfgang Skibar (2723902), Judith E. Farnberger (6550892), Judith E. Farnberger, Sarah Bierbaumer (6550895), Wolfgang Skibar   +11 more
core   +1 more source

A randomised controlled trial investigating the effect of vitamin B12 supplementation on neurological function in healthy older people: the Older People and Enhanced Neurological function (OPEN) study protocol [ISRCTN54195799]. [PDF]

, 2011
BACKGROUND: Vitamin B12 deficiency is common in older people and the prevalence increases with age. Vitamin B12 deficiency may present as macrocytic anaemia, subacute combined degeneration of the spinal cord, or as neuropathy, but is often asymptomatic ...
Allen, Elizabeth, Kerry Mills, Whyte, K, Fletcher, Astrid E, Elbourne, Diana, Richards, Marcus, Ken Whyte, Mills, Kerry, Robert Clarke, Richards, M, Letley, Louise, Dangour, Alan D, Elbourne, D, Mills, K, Ricardo Uauy, Whyte, Ken, Louise Letley, Dangour, AD, Fletcher, AE, Diana Elbourne, Fasey, Nicky, Uauy, Ricardo, Alan D Dangour, Uauy, R, Astrid E Fletcher, Marcus Richards, Clarke, Robert, Clarke, R, Nicky Fasey, Elizabeth Allen, Fasey, N, Allen, E, Letley, L   +32 more
core   +1 more source

Cobalamin deficiency resulting in a rare haematological disorder: a case report

Journal of Medical Case Reports, 2009
Introduction We present the case of a patient with a cobalamin deficiency resulting in pancytopaenia, emphasizing the importance to define, diagnose and treat cobalamin deficiency. Case presentation A 52-year-old man from the Democratic Republic of Congo
Chapuis Thomas M, Favrat Bernard, Bodenmann Patrick   +2 more
doaj   +1 more source

Utilization of cobalamin is ubiquitous in early-branching fungal phyla [PDF]

, 2021
Cobalamin is a cofactor present in essential metabolic pathways in animals and one of the water-soluble vitamins. It is a complex compound synthesized solely by prokaryotes. Cobalamin dependence is scattered across the tree of life.
Orłowska, Małgorzata, Muszewska, Anna, Steczkiewicz, Kamil   +2 more
core   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

A dodecylamine derivative of cyanocobalamin potently inhibits the activities of cobalamin-dependent methylmalonyl-CoA mutase and methionine synthase of Caenorhabditis elegans

FEBS Open Bio, 2014
In this study, we showed that cyanocobalamin dodecylamine, a ribose 5′-carbamate derivative of cyanocobalamin, was absorbed and accumulated to significant levels by Caenorhabditis elegans and was not further metabolized.
Tomohiro Bito, Yukinori Yabuta, Tsuyoshi Ichiyanagi, Tsuyoshi Kawano, Fumio Watanabe   +4 more
doaj   +1 more source

Identification and quantitation of cobalamin and cobalamin analogues in human feces [PDF]

The American Journal of Clinical Nutrition, 2008
Cobalamin (vitamin B-12) and cobalamin analogues are present in human feces, but a complete identification has not been established, and the amounts present have not been determined.We aimed to develop a liquid chromatography-mass spectrometry method for cobalamin and cobalamin analogues and to identify and quantitiate the amounts present in human ...
Robert H, Allen, Sally P, Stabler
openaire   +2 more sources