Results 21 to 30 of about 4,498 (182)

Rifabutin-Cobicistat Drug Interaction Resulting in Severe Bilateral Panuveitis

Case Reports in Ophthalmology, 2020
We report a novel case of severe bilateral panuveitis with hypopyon secondary to rifabutin and cobicistat drug interaction in the setting of human immunodeficiency virus (HIV) infection and latent tuberculosis (TB).
Christopher B. Toomey, Jeffrey Lee, Doran B. Spencer   +2 more
doaj   +1 more source

Biotransformation of Cobicistat: Metabolic Pathways and Enzymes [PDF]

Drug Metabolism Letters, 2016
Cobicistat (COBI) is a pharmacoenhancer for antiretroviral therapy.The current study was designed to profile the metabolic pathways of COBI and to determine the enzymes that contribute to COBI metabolism.We screened COBI metabolites in mice and human liver microsomes. We also used cDNAexpressed human cytochromes P450 (CYPs) to explore the role of human
Pengcheng, Wang, Amina I, Shehu, Ke, Liu, Jie, Lu, Xiaochao, Ma   +4 more
openaire   +2 more sources

Trends in Utilization of Statin Therapy and Contraindicated Statin Use in HIV‐‐Infected Adults Treated With Antiretroviral Therapy From 2007 Through 2015

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
Background HIV is associated with an increased risk for atherosclerotic cardiovascular disease, which may result in many people living with HIV taking a statin.
Robert S. Rosenson, Lisandro D. Colantonio, Greer A. Burkholder, Ligong Chen, Paul Muntner   +4 more
doaj   +1 more source

Pharmacokinetics (PK) of ethinylestradiol/levonorgestrel co-administered with atazanavir/cobicistat

HIV Research & Clinical Practice, 2019
Background and objectives: Access to safe and reliable contraception in the context of ARVs is essential. This study aimed to investigate the steady-state pharmacokinetics (PK) of ethinylestradiol/levonorgestrel (EE/LNG) 30/150 μg (Microgynon®) and ...
Emilie R Elliot, Elisa Bisdomini, Sujan Dilly Penchala, Saye Khoo, Nneka Nwokolo, Marta Boffito   +5 more
doaj   +1 more source

Endothelial Glycocalyx Integrity in Treatment-Naïve People Living with HIV before and One Year after Antiretroviral Treatment Initiation

Viruses, 2023
Endothelial glycocalyx (EG) derangement has been associated with cardiovascular disease (CVD). Studies on EG integrity among people living with HIV (PLWH), are lacking.
Paraskevi C. Fragkou, Ignatios Ikonomidis, Dimitrios Benas, Dimitra Kavatha, Charalampos D. Moschopoulos, Konstantinos Protopapas, Gavriella Kostelli, John Thymis, Dionysia Mpirmpa, Irene Galani, Maria Tsakona, Chrysanthi Oikonomopoulou, George Theocharous, Vassilis G. Gorgoulis, Parisis Gallos, Sotirios Tsiodras, Anastasia Antoniadou, Antonios Papadopoulos, Helen Triantafyllidi   +18 more
doaj   +1 more source

Data on the stability of darunavir/cobicistat suspension after tablet manipulation

Data in Brief, 2020
The COVID-19 outbreak is now one of the most critical crises to manage for most of the national healthcare systems in the world. In the absence of authorised pharmacological treatments, many antiretrovirals, including darunavir/cobicistat fixed ...
D. Zanon, A. Manca, A. De Nicolò, A. D'Avolio, U.M. Musazzi, F. Cilurzo, N. Maximova, C. Tomasello, P. Minghetti   +8 more
doaj   +1 more source

Stability-indicating method development and validation for the concurrent determination of darunavir, cobicistat, emtricitabine and tenofovir alafenamide by UPLC in bulk and tablet dosage forms

Future Journal of Pharmaceutical Sciences, 2021
Background Tablet dosage forms containing combination of darunavir a protease inhibitor, cobicistat a cytochrome P450 3A inhibitor, emtricitabine and tenofovir alafenamide which were nucleoside reverse transcriptase inhibitors were approved by USFDA on ...
M. Satya Venkata Sakuntala, A. Lakshmana Rao, M. William Carey   +2 more
doaj   +1 more source

Week 96 Results of Switching from Tenofovir Disoproxil Fumarate-Based Antiretroviral Therapy to Coformulated Elvitegravir, Cobicistat, Emtricitabine, and Tenofovir Alafenamide among HIV/Hepatitis B Virus-Coinfected Patients

Microbiology Spectrum, 2023
Data regarding the durability of tenofovir alafenamide (TAF)-containing antiretroviral therapy (ART) in maintaining hepatitis B virus (HBV) viral suppression among HIV/HBV-coinfected patients are limited.
Yu-Shan Huang, Chien-Yu Cheng, Hsin-Yun Sun, Shu-Hsing Cheng, Po-Liang Lu, Chen-Hsiang Lee, Yuan-Ti Lee, Hung-Chin Tsai, Chia-Jui Yang, Chun-Eng Liu, Bo-Huang Liou, Shih-Ping Lin, Sung-Hsi Huang, Mao-Wang Ho, Hung-Jen Tang, Chien-Ching Hung   +15 more
doaj   +1 more source

Clinical efficacy of antiviral agents against coronavirus disease 2019: A systematic review of randomized controlled trials

Journal of Microbiology, Immunology and Infection, 2021
Despite aggressive efforts on containment measures for the coronavirus disease 2019 (COVID-19) pandemic around the world, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is continuously spreading.
Chih-Cheng Lai, Chien-Ming Chao, Po-Ren Hsueh   +2 more
doaj   +1 more source

The effect of ivermectin alone and in combination with cobicistat or elacridar in experimental Schistosoma mansoni infection in mice

Scientific Reports, 2021
Schistosoma mansoni is less susceptible to the antiparasitic drug ivermectin than other helminths. By inhibiting the P-glycoprotein or cytochrome P450 3A in mice host or parasites in a murine model, we aimed at increasing the sensitivity of S. mansoni to
Belén Vicente, Julio López-Abán, Juliane Chaccour, Juan Hernández-Goenaga, Patricia Nicolas, Pedro Fernández-Soto, Antonio Muro, Carlos Chaccour   +7 more
doaj   +1 more source