Results 31 to 40 of about 5,352 (210)
Journal of Virus Eradication, 2018 Background: Higher plasma tenofovir concentrations are associated with higher risks of renal and bone adverse events. The pharmacokinetic boosters ritonavir (RTV) and cobicistat (COBI) significantly increase plasma area under the curve (AUC ...
Andrew Hill +3 more
doaj +1 more source
Rifabutin-Cobicistat Drug Interaction Resulting in Severe Bilateral Panuveitis
Case Reports in Ophthalmology, 2020 We report a novel case of severe bilateral panuveitis with hypopyon secondary to rifabutin and cobicistat drug interaction in the setting of human immunodeficiency virus (HIV) infection and latent tuberculosis (TB).
Christopher B. Toomey +2 more
doaj +1 more source
Biotransformation of Cobicistat: Metabolic Pathways and Enzymes [PDF]
Drug Metabolism Letters, 2016 Cobicistat (COBI) is a pharmacoenhancer for antiretroviral therapy.The current study was designed to profile the metabolic pathways of COBI and to determine the enzymes that contribute to COBI metabolism.We screened COBI metabolites in mice and human liver microsomes. We also used cDNAexpressed human cytochromes P450 (CYPs) to explore the role of human
Pengcheng, Wang +4 more
openaire +2 more sources
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018 Background HIV is associated with an increased risk for atherosclerotic cardiovascular disease, which may result in many people living with HIV taking a statin.
Robert S. Rosenson +4 more
doaj +1 more source
Elvitegravir/cobicistat pharmacokinetics in pregnant and postpartum women with HIV [PDF]
, 2018 OBJECTIVE: To evaluate elvitegravir and cobicistat pharmacokinetics during pregnancy compared with postpartum and in infant washout samples after delivery.
Smith, Elizabeth +14 more
core +1 more source
Iatrogenic Cushing's syndrome by an interaction between cobicistat and fluticasone: a case report
, 2021 SUMMARY We report a case of iatrogenic Cushing's syndrome associated with an interaction between cobicistat and fluticasone in a seropositive woman treated with elvitegravir/cobicistat/emtricitabina/TAF (Genvoya®).
Matilla García,E +5 more
core +1 more source
Pharmacokinetics (PK) of ethinylestradiol/levonorgestrel co-administered with atazanavir/cobicistat
HIV Research & Clinical Practice, 2019 Background and objectives: Access to safe and reliable contraception in the context of ARVs is essential. This study aimed to investigate the steady-state pharmacokinetics (PK) of ethinylestradiol/levonorgestrel (EE/LNG) 30/150 μg (Microgynon®) and ...
Emilie R Elliot +5 more
doaj +1 more source
Viruses, 2023 Endothelial glycocalyx (EG) derangement has been associated with cardiovascular disease (CVD). Studies on EG integrity among people living with HIV (PLWH), are lacking.
Paraskevi C. Fragkou +18 more
doaj +1 more source
Cobicistat as a Potential Booster of Ponatinib and Dasatinib Exposure in a CML Patient: A Case Study [PDF]
, 2023 The authors present a case of a 57-year-old patient with chronic myeloid leukemia who was treated with ponatinib and subsequently treated with dasatinib.
Oude Munnink, Thijs H +9 more
core +1 more source
Data on the stability of darunavir/cobicistat suspension after tablet manipulation
Data in Brief, 2020 The COVID-19 outbreak is now one of the most critical crises to manage for most of the national healthcare systems in the world. In the absence of authorised pharmacological treatments, many antiretrovirals, including darunavir/cobicistat fixed ...
D. Zanon +8 more
doaj +1 more source