Results 31 to 40 of about 901 (171)

Trends in Utilization of Statin Therapy and Contraindicated Statin Use in HIV‐‐Infected Adults Treated With Antiretroviral Therapy From 2007 Through 2015

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
Background HIV is associated with an increased risk for atherosclerotic cardiovascular disease, which may result in many people living with HIV taking a statin.
Robert S. Rosenson, Lisandro D. Colantonio, Greer A. Burkholder, Ligong Chen, Paul Muntner   +4 more
doaj   +1 more source

Population pharmacokinetic analysis of elvitegravir and cobicistat in HIV-1-infected individuals [PDF]

, 2021
Objectives Co-formulated elvitegravir, cobicistat, tenofovir disoproxil fumarate and emtricitabine is among the preferred regimens for first-line ART. A population approach was used to characterize the pharmacokinetics of elvitegravir and cobicistat and ...
Decosterd, Laurent A., Keiser, O., Stöckle, M., Aouri, Manel, Martinez de Tejada, B., Hösli, I., Marzolini, C., Haerry, D., Battegay, M., Vernazza, P., Rudin, C., Kahlert, C., Böni, J., Kovari, H., Nadal, D., Weber, R., Kouyos, R., Regenass, S., Dollenmaier, G., Egger, M., Schmid, P., Günthard, H., Martinetti, G., Guidi, Monia, Bucher, HC, Hasse, B., Yerly, S., Braun, DL, Gaspar, Frédéric, Barceló, Catalina, Nicca, D., Burton-Jeangros, C., Buclin, Thierry, Bernasconi, E., Calmy, A., Trkola, A., Cavassini, M., Kaiser, L., Aubert, V., Elzi, L., Gorgievski, M., Hirsch, HH, Csajka, Chantal, Rotger, Margalida, Fellay, J., Panchaud, Alice, Müller, N., Rauch, A., Ledergerber, B., Tarr, P., Pantaleo, G., Metzner, K., Furrer, H., Hoffmann, M., Fux, CA, Speck, R., Klimkait, T., Fehr, J., Cavassini, Matthias, Schöni-Affolter, F.   +59 more
core  

Pharmacokinetics (PK) of ethinylestradiol/levonorgestrel co-administered with atazanavir/cobicistat

HIV Research & Clinical Practice, 2019
Background and objectives: Access to safe and reliable contraception in the context of ARVs is essential. This study aimed to investigate the steady-state pharmacokinetics (PK) of ethinylestradiol/levonorgestrel (EE/LNG) 30/150 μg (Microgynon®) and ...
Emilie R Elliot, Elisa Bisdomini, Sujan Dilly Penchala, Saye Khoo, Nneka Nwokolo, Marta Boffito   +5 more
doaj   +1 more source

Endothelial Glycocalyx Integrity in Treatment-Naïve People Living with HIV before and One Year after Antiretroviral Treatment Initiation

Viruses, 2023
Endothelial glycocalyx (EG) derangement has been associated with cardiovascular disease (CVD). Studies on EG integrity among people living with HIV (PLWH), are lacking.
Paraskevi C. Fragkou, Ignatios Ikonomidis, Dimitrios Benas, Dimitra Kavatha, Charalampos D. Moschopoulos, Konstantinos Protopapas, Gavriella Kostelli, John Thymis, Dionysia Mpirmpa, Irene Galani, Maria Tsakona, Chrysanthi Oikonomopoulou, George Theocharous, Vassilis G. Gorgoulis, Parisis Gallos, Sotirios Tsiodras, Anastasia Antoniadou, Antonios Papadopoulos, Helen Triantafyllidi   +18 more
doaj   +1 more source

Darunavir-Cobicistat versus Lopinavir-Ritonavir for COVID-19 Pneumonia: Qatar's Experience [PDF]

, 2022
Background: Coronavirus Disease 2019 (COVID-19) was first discovered in China and resulted in a pandemic crisis. 1,2 Many agents were investigated with inconclusive outcomes.
Elmekaty, Eman Zeyad I., Al Soub, Hussam, Al Maslamani, Muna, Abu Khattab, Mohammed, Hassanin, Rania, Al-Khal, Abdullatif, Rustom, Fatima, Eltaib, Sitelbanat, Alibrahim, Rim, Mohamed Ibrahim, Mohamed Izham, Elsayed, Ahmed   +10 more
core   +1 more source

Stability-indicating method development and validation for the concurrent determination of darunavir, cobicistat, emtricitabine and tenofovir alafenamide by UPLC in bulk and tablet dosage forms

Future Journal of Pharmaceutical Sciences, 2021
Background Tablet dosage forms containing combination of darunavir a protease inhibitor, cobicistat a cytochrome P450 3A inhibitor, emtricitabine and tenofovir alafenamide which were nucleoside reverse transcriptase inhibitors were approved by USFDA on ...
M. Satya Venkata Sakuntala, A. Lakshmana Rao, M. William Carey   +2 more
doaj   +1 more source

Week 96 Results of Switching from Tenofovir Disoproxil Fumarate-Based Antiretroviral Therapy to Coformulated Elvitegravir, Cobicistat, Emtricitabine, and Tenofovir Alafenamide among HIV/Hepatitis B Virus-Coinfected Patients

Microbiology Spectrum, 2023
Data regarding the durability of tenofovir alafenamide (TAF)-containing antiretroviral therapy (ART) in maintaining hepatitis B virus (HBV) viral suppression among HIV/HBV-coinfected patients are limited.
Yu-Shan Huang, Chien-Yu Cheng, Hsin-Yun Sun, Shu-Hsing Cheng, Po-Liang Lu, Chen-Hsiang Lee, Yuan-Ti Lee, Hung-Chin Tsai, Chia-Jui Yang, Chun-Eng Liu, Bo-Huang Liou, Shih-Ping Lin, Sung-Hsi Huang, Mao-Wang Ho, Hung-Jen Tang, Chien-Ching Hung   +15 more
doaj   +1 more source

Darunavir concentrations in CSF of HIV-infected individuals when boosted with cobicistat versus ritonavir [PDF]

, 2021
Objectives Cobicistat and ritonavir have different inhibitory profiles for drug transporters that could impact the distribution of co-administered drugs.
Bartels, Hanni, Decosterd, Laurent, Battegay, Manuel, Marzolini, Catia   +3 more
core  

Clinical efficacy of antiviral agents against coronavirus disease 2019: A systematic review of randomized controlled trials

Journal of Microbiology, Immunology and Infection, 2021
Despite aggressive efforts on containment measures for the coronavirus disease 2019 (COVID-19) pandemic around the world, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is continuously spreading.
Chih-Cheng Lai, Chien-Ming Chao, Po-Ren Hsueh   +2 more
doaj   +1 more source

Towards human cardiac new approach methodologies (NAMs) to evaluate the combination of repolarization prolonging and shortening drugs: a pilot study

Frontiers in Drug Discovery
Background and PurposeNonclinical human cardiac new approach methodologies (NAMs), including human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) combined with multielectrode array (MEA) represent a highly predictive in vitro model for ...
Robert M. Geiger, Carlos Serna, Bhavya Bhardwaj, Tromondae K. Feaster, Ksenia Blinova   +4 more
doaj   +1 more source