Results 31 to 40 of about 50,818 (248)

How the Cobra Got Its Flesh-Eating Venom: Cytotoxicity as a Defensive Innovation and Its Co-Evolution with Hooding, Aposematic Marking, and Spitting

Toxins, 2017
The cytotoxicity of the venom of 25 species of Old World elapid snake was tested and compared with the morphological and behavioural adaptations of hooding and spitting. We determined that, contrary to previous assumptions, the venoms of spitting species
Nadya Panagides, Timothy N.W. Jackson, Maria P. Ikonomopoulou, Kevin Arbuckle, Rudolf Pretzler, Daryl C. Yang, Syed A. Ali, Ivan Koludarov, James Dobson, Brittany Sanker, Angelique Asselin, Renan C. Santana, Iwan Hendrikx, Harold van der Ploeg, Jeremie Tai-A-Pin, Romilly van den Bergh, Harald M.I. Kerkkamp, Freek J. Vonk, Arno Naude, Morné A. Strydom, Louis Jacobsz, Nathan Dunstan, Marc Jaeger, Wayne C. Hodgson, John Miles, Bryan G. Fry   +25 more
doaj   +1 more source

WTAP‐Mediated m6A Modification Targets the LRP1‐Lipid Metabolism Axis to Regulate Joint Cartilage Regeneration

Advanced Science, EarlyView.
WTAP drives cartilage regeneration by activating an LRP1‐dependent lipid metabolic program in macrophages, enhancing IL‐10 and TGF‐β secretion to promote chondrogenic differentiation. Leveraging this mechanism, virtual screening identifies LRP1‐targeting compounds that effectively stimulate cartilage repair, highlighting a druggable epigenetic ...
Chenyan Huang, Chenyu Deng, Zhengrong Gao, Chen Chen, Huimin Zheng, Yue Yang, Yan Wei   +6 more
wiley   +1 more source

Balancing Stealth and Targetability: cCPP‐ and PEG‐Modified Liposomes for the Targeted Delivery of Anti‐HER2 Nanobodies

Advanced Science, EarlyView.
This study addresses the rapid renal clearance of anti‐HER2 nanobodies by developing specialized liposomal carriers. It details the formulation of dual modified liposomes, demonstrating how PEGylation preserves structural integrity and cell‐penetrating peptides enhance cellular interaction.
Giulia Pander, Maria del Pilar Palacios Cisneros, Clara Certa, Megan Stierli, Katharina Beck, Nicolas Färber, Lisa Blank, Fiona Tanner, Eric Mühlberg, Sabrina Wohlfart, Christian Kleist, Jörg Huwyler, Gert Fricker, Walter Mier, Philipp Uhl   +14 more
wiley   +1 more source

COBrA and COBrA-CT: Ontology Engineering Tools [PDF]

, 2007
COBrA is a Java-based ontology editor for bio-ontologies and anatomies that differs from other editors by supporting the linking of concepts between two ontologies, and providing sophisticated analysis and verification functions. In addition to the Gene Ontology and Open Biology Ontologies formats, COBrA can import and export ontologies in the Semantic
Stuart Aitken, Yin Chen
openaire   +1 more source

Synthesis of functionalized polyolefins in a new continuous bench‐scale reactor apparatus

AIChE Journal, EarlyView.
Abstract In‐reactor functionalized polyolefins (FPOs), produced by molecular catalysts, are a new class of polymer materials with applications ranging from high performance adhesives to bitumen compatibilization. In this work, we disclose a procedure for the synthesis of FPOs in a new Continuous Bench‐scale Reactor Apparatus (COBRA).
Miloud Bouyahyi, Job Guzman, Travis Conant, Reggie Tennyson, Christoph Brose, Riccardo Conti, Peter Kolb, Andreas Müller   +7 more
wiley   +1 more source

Coagulotoxic Cobras: Clinical Implications of Strong Anticoagulant Actions of African Spitting Naja Venoms That Are Not Neutralised by Antivenom but Are by LY315920 (Varespladib)

Toxins, 2018
Snakebite is a global tropical disease that has long had huge implications for human health and well-being. Despite its long-standing medical importance, it has been the most neglected of tropical diseases.
Mátyás A. Bittenbinder, Christina N. Zdenek, Bianca op den Brouw, Nicholas J. Youngman, James S. Dobson, Arno Naude, Freek J. Vonk, Bryan G. Fry   +7 more
doaj   +1 more source

Patient‐Mounted Neuro Optical Coherence Tomography for Targeted Minimally Invasive Micro‐Resolution Volumetric Imaging in Brain In Vivo

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
Herein, a patient‐mounted neuro optical coherence tomography system that integrates a 5 degrees‐of‐freedom skull‐mounted robot (Skullbot) with a 0.6 mm neuroendoscope for targeted, minimally invasive deep brain imaging, is developed. The system offers high‐resolution imaging with precise deployment, demonstrated through successful tumor imaging in a ...
Chao Xu, Zhiwei Fang, Huxin Gao, Tinghua Zhang, Tao Zhang, Peng Liu, Hongliang Ren, Wu Yuan   +7 more
wiley   +1 more source

CoBRA without experts: New paradigm for software development effort estimation using COCOMO metrics

, 2023
Software development effort estimation (SDEE) is a critical activity in developing software. Accurate effort estimation in the early phases of software design life cycle has important effects on the success of software projects. COCOMO (Constructive Cost
Sami, Ashkan, Tahayori, Hooman, Feizpour, Elham, Elham Feizpour, Ashkan Sami, Hooman Tahayori   +5 more
core   +1 more source

Referências hematológicas para a jararaca de rabo branco (Bothrops leucurus) recém capturadas da natureza Hematological references for wild recently-caught white-tailed lancehead (Bothrops leucurus)

Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 2006
The hematological values for the specie Bothrops leucurus, recently captured from nature, were determined from blood samples of 29 snakes (11 males and 18 females).
K.F. Grego, J.A.S. Alves, L.C. Rameh de Albuquerque, W. Fernandes   +3 more
doaj   +1 more source

Porcine kidney xenotransplantation: From primate models to clinical reality

Animal Models and Experimental Medicine, EarlyView.
In the face of a critical shortage of human donor kidneys for end‐stage renal disease patients, porcine kidney xenotransplantation has emerged as a viable solution. This field has navigated major hurdles, including immune rejection, physiological incompatibilities, potential biomechanical differences and the risk of cross‐species infection. To overcome
Zihang Guo, Ling Zhang, Shoulong Deng, Chuan Qin   +3 more
wiley   +1 more source