Results 31 to 40 of about 446,893 (239)

Advances in the Synthesis of Fluorinated Scaffolds by Transition Metal-Catalyzed C–H Bond Activation

open access: yesCHIMIA, 2020
Thanks to the unique features of the fluorine atom and the fluorinated groups, fluorine-containing molecules are essential. Therefore, the search for new fluorinated groups as well as straightforward and original methodologies for their installation is ...
Sara Mazet   +2 more
doaj   +1 more source

A strategic perspective for managing socio-technical systems: the missing link [PDF]

open access: yes, 2009
Most man-made systems around us are mainly socio-technical systems. As such it is imperative that to manage such systems effectively we need to understand their properties at both the micro and macro level and the holistic functioning of such systems ...
John, Godfaurd, RICS - COBRA
core  

Lyophilized Synthetic Platelets: In Vitro Characterization and in Vivo Evaluation in Mouse Thrombocytopenia Model

open access: yesAdvanced Science, EarlyView.
ABSTRACT Platelet transfusions to treat bleeding complications use donor‐derived platelets stored at room‐temperature, that have a shelf‐life of only 5–7 days due to bacterial contamination risks. Cold‐stored and freeze‐dried platelets are being investigated for extending shelf‐life, but these still have the inherent challenge of donor‐dependency.
Ujjal Didar Singh Sekhon   +20 more
wiley   +1 more source

How the Cobra Got Its Flesh-Eating Venom: Cytotoxicity as a Defensive Innovation and Its Co-Evolution with Hooding, Aposematic Marking, and Spitting

open access: yesToxins, 2017
The cytotoxicity of the venom of 25 species of Old World elapid snake was tested and compared with the morphological and behavioural adaptations of hooding and spitting. We determined that, contrary to previous assumptions, the venoms of spitting species
Nadya Panagides   +25 more
doaj   +1 more source

COBRA Subsidies for Laid-Off Workers: An Initial Report Card [PDF]

open access: yes, 2009
Reviews the implementation of the government subsidy of COBRA health insurance premiums for laid-off workers in the 2009 stimulus package and its effects on COBRA enrollment and medical spending.
Jack A. Meyer   +3 more
core  

WTAP‐Mediated m6A Modification Targets the LRP1‐Lipid Metabolism Axis to Regulate Joint Cartilage Regeneration

open access: yesAdvanced Science, EarlyView.
WTAP drives cartilage regeneration by activating an LRP1‐dependent lipid metabolic program in macrophages, enhancing IL‐10 and TGF‐β secretion to promote chondrogenic differentiation. Leveraging this mechanism, virtual screening identifies LRP1‐targeting compounds that effectively stimulate cartilage repair, highlighting a druggable epigenetic ...
Chenyan Huang   +6 more
wiley   +1 more source

Maintaining Health Insurance During a Recession: Likely COBRA Eligibility [PDF]

open access: yes, 2009
Assesses laid-off workers' eligibility and financial ability to extend employer-sponsored insurance through COBRA. Recommends extending COBRA and providing premium assistance, as well as expanding Medicaid and State Children's Health Insurance ...
Cathy Schoen   +3 more
core  

Patient‐Mounted Neuro Optical Coherence Tomography for Targeted Minimally Invasive Micro‐Resolution Volumetric Imaging in Brain In Vivo

open access: yesAdvanced Intelligent Systems, Volume 7, Issue 3, March 2025.
Herein, a patient‐mounted neuro optical coherence tomography system that integrates a 5 degrees‐of‐freedom skull‐mounted robot (Skullbot) with a 0.6 mm neuroendoscope for targeted, minimally invasive deep brain imaging, is developed. The system offers high‐resolution imaging with precise deployment, demonstrated through successful tumor imaging in a ...
Chao Xu   +7 more
wiley   +1 more source

Realizing Health Reform's Potential: When Unemployed Means Uninsured: The Toll of Job Loss on Health Coverage, and How the Affordable Care Act Will Help [PDF]

open access: yes, 2011
Examines how the 2010 healthcare reform will significantly expand affordable health coverage options for the unemployed who cannot afford COBRA. Calls for re-establishing COBRA premium subsidies to bridge coverage gaps until it is implemented in ...
Michelle M. Doty   +3 more
core  

Porcine kidney xenotransplantation: From primate models to clinical reality

open access: yesAnimal Models and Experimental Medicine, EarlyView.
In the face of a critical shortage of human donor kidneys for end‐stage renal disease patients, porcine kidney xenotransplantation has emerged as a viable solution. This field has navigated major hurdles, including immune rejection, physiological incompatibilities, potential biomechanical differences and the risk of cross‐species infection. To overcome
Zihang Guo   +3 more
wiley   +1 more source

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