Profiling cytotoxicity of nanofractionated elapid snake venoms in human cell lines representing different tissues [PDF]
Journal of Pharmaceutical AnalysisElapid snakebites cause severe toxicity, predominantly neurotoxicity and general cytotoxicity. However, the specific cellular impacts of individual venom toxins remain largely underexplored.
Jeroen Kool +2 more
exaly +4 more sources
A Quest for a Universal Plasma-Derived Antivenom Against All Elapid Neurotoxic Snake Venoms
Frontiers in Immunology, 2021 This review describes the research aimed at the development of universal antivenom against elapid neurotoxic snake venoms. The antivenoms produced in Thailand in the 1980s were of low potency, especially against the elapid venoms.
Kavi Ratanabanangkoon
exaly +3 more sources
Differential Effects of Marimastat and Prinomastat on the Metalloprotease Activity of Various Snake Venoms [PDF]
ToxinsSnakebite envenoming is a neglected tropical disease, responsible for approximately 140,000 deaths globally each year. Vipers and elapid snakes represent the most significant snake families in medical contexts, exhibiting a variety of venom components ...
Mahtab Khatibi +6 more
doaj +2 more sources
Venom Down Under: Dynamic Evolution of Australian Elapid Snake Toxins
Toxins, 2013 Despite the unparalleled diversity of venomous snakes in Australia, research has concentrated on a handful of medically significant species and even of these very few toxins have been fully sequenced.
Timothy Jackson +2 more
exaly +3 more sources
Antimicrobial Activity of Micrurus Venoms and Bioactive Films Functionalized with Purified L-Amino Acid Oxidase [PDF]
ToxinsPhytopathogenic bacteria and fungi significantly reduce fruit and vegetable yields, resulting in substantial economic losses. Conventional management relies on synthetic agrochemicals; however, their intensive use poses risks to human health ...
Vitelbina Núñez Rangel +7 more
doaj +2 more sources
X Marks the Clot: Evolutionary and Clinical Implications of Divergences in Procoagulant Australian Elapid Snake Venoms [PDF]
ToxinsAustralian elapid snakes possess potent procoagulant venoms, capable of inducing severe venom-induced consumption coagulopathy (VICC) in snakebite victims through rapid activation of the coagulation cascade by converting the FVII and prothrombin zymogens
Holly Morecroft +5 more
doaj +2 more sources
Heating up the Blunts: Prothrombin Activation, with Factor Va as an Obligate Cofactor, Is the Dominant Procoagulant Mechanism of Blunt-Nosed Viper Venoms (Macrovipera Species) [PDF]
ToxinsVenoms of the Palearctic vipers in the Macrovipera genus cause severe procoagulant clinical effects, yet the precise molecular targets remain incompletely defined. To fill this toxicological knowledge gap, we tested five Macrovipera venoms—M.
Patrick S. Champagne +2 more
doaj +2 more sources
Assessing the Utility of Broad-Acting Inhibitors as Therapeutics in Diverse Venoms [PDF]
ToxinsExamination of venom constituent bioactivities from diverse venomous animals shows certain highly conserved classes, including enzymes (e.g., phospholipases and metalloproteinases) and pore-forming proteins.
Raechel Kadler +2 more
doaj +2 more sources
Toxins, 2023 The cytotoxicity caused by snake venoms is a serious medical problem that greatly contributes to the morbidity observed in snakebite patients. The cytotoxic components found in snake venoms belong to a variety of toxin classes and may cause cytotoxic ...
Eric Wachtel +8 more
doaj +1 more source
PLoS Neglected Tropical Diseases, 2021 Development of a rapid, on-site detection tool for snakebite is highly sought after, owing to its clinically and forensically relevant medicolegal significance.
Sherin Kaul +6 more
doaj +1 more source