Differential Effects of Marimastat and Prinomastat on the Metalloprotease Activity of Various Snake Venoms [PDF]
ToxinsSnakebite envenoming is a neglected tropical disease, responsible for approximately 140,000 deaths globally each year. Vipers and elapid snakes represent the most significant snake families in medical contexts, exhibiting a variety of venom components ...
Mahtab Khatibi +6 more
doaj +3 more sources
From Venom to Vein: Factor VII Activation as a Major Pathophysiological Target for Procoagulant Australian Elapid Snake Venoms [PDF]
ToxinsAustralian elapid snake venoms are uniquely procoagulant, utilizing blood clotting enzyme Factor Xa (FXa) as a toxin, which evolved as a basal trait in this clade.
Uthpala Chandrasekara +5 more
doaj +3 more sources
X Marks the Clot: Evolutionary and Clinical Implications of Divergences in Procoagulant Australian Elapid Snake Venoms [PDF]
ToxinsAustralian elapid snakes possess potent procoagulant venoms, capable of inducing severe venom-induced consumption coagulopathy (VICC) in snakebite victims through rapid activation of the coagulation cascade by converting the FVII and prothrombin zymogens
Holly Morecroft +5 more
doaj +3 more sources
Venom Down Under: Dynamic Evolution of Australian Elapid Snake Toxins [PDF]
Toxins, 2013 Despite the unparalleled diversity of venomous snakes in Australia, research has concentrated on a handful of medically significant species and even of these very few toxins have been fully sequenced.
Timothy N. W. Jackson +9 more
doaj +8 more sources
Heating up the Blunts: Prothrombin Activation, with Factor Va as an Obligate Cofactor, Is the Dominant Procoagulant Mechanism of Blunt-Nosed Viper Venoms (Macrovipera Species) [PDF]
ToxinsVenoms of the Palearctic vipers in the Macrovipera genus cause severe procoagulant clinical effects, yet the precise molecular targets remain incompletely defined. To fill this toxicological knowledge gap, we tested five Macrovipera venoms—M.
Patrick S. Champagne +2 more
doaj +3 more sources
A Quest for a Universal Plasma-Derived Antivenom Against All Elapid Neurotoxic Snake Venoms
Frontiers in Immunology, 2021 This review describes the research aimed at the development of universal antivenom against elapid neurotoxic snake venoms. The antivenoms produced in Thailand in the 1980s were of low potency, especially against the elapid venoms.
Kavi Ratanabanangkoon
exaly +3 more sources
Toxins, 2021 Some Australian elapids possess potently procoagulant coagulotoxic venoms which activate the zymogen prothrombin into the functional enzyme thrombin. Although the activity of Australian elapid prothrombin-activators has been heavily investigated with ...
Nicholas J. Youngman +2 more
doaj +2 more sources
A Combined Bioassay and Nanofractionation Approach to Investigate the Anticoagulant Toxins of Mamba and Cobra Venoms and Their Inhibition by Varespladib [PDF]
Toxins, 2022 Envenomation by elapid snakes primarily results in neurotoxic symptoms and, consequently, are the primary focus of therapeutic research concerning such venoms. However, mounting evidence suggests these venoms can additionally cause coagulopathic symptoms,
Arif Arrahman +7 more
doaj +2 more sources
Toxins, 2014 Elapid snake venom is a highly valuable, but till now mainly unexplored, source of pharmacologically important peptides. We analyzed the peptide fractions with molecular masses up to 10 kDa of two elapid snake venoms—that of the African cobra, N.
Aisha Munawar +10 more
doaj +2 more sources
Crystal structure and functional characterization of an Asp49 phospholipase A<sub>2</sub> from the bushmaster (Lachesis muta). [PDF]
Acta Crystallogr F Struct Biol CommunThe crystal structure of an Asp49 phospholipase A2 from L. muta is reported, revealing a tetrameric assembly, catalytic conservation and a polarized electrostatic surface potentially linked to membrane targeting.Snake‐venom phospholipases A2 (PLA2s) are small, structurally conserved enzymes that contribute significantly to the pathophysiology of ...
Neyra Chama NE +9 more
europepmc +2 more sources