Results 41 to 50 of about 2,588 (206)

Molecular Evolution and Phylogeny of Elapid Snake Venom Three-Finger Toxins [PDF]

Journal of Molecular Evolution, 2003
Animal venom components are of considerable interest to researchers across a wide variety of disciplines, including molecular biology, biochemistry, medicine, and evolutionary genetics. The three-finger family of snake venom peptides is a particularly interesting and biochemically complex group of venom peptides, because they are encoded by a large ...
Fry, B.G., Wüster, W., Kini, R.M., Brusic, V., Khan, A., Venkataraman, D., Rooney, A.P.   +6 more
openaire   +3 more sources

Anticoagulant Activity of Naja nigricollis Venom Is Mediated by Phospholipase A2 Toxins and Inhibited by Varespladib

Toxins, 2021
Bites from elapid snakes typically result in neurotoxic symptoms in snakebite victims. Neurotoxins are, therefore, often the focus of research relating to understanding the pathogenesis of elapid bites.
Taline D. Kazandjian, Arif Arrahman, Kristina B. M. Still, Govert W. Somsen, Freek J. Vonk, Nicholas R. Casewell, Mark C. Wilkinson, Jeroen Kool   +7 more
doaj   +1 more source

Impact of Naja nigricollis Venom on the Production of Methaemoglobin

Toxins, 2018
Snakebite envenomation is an affliction currently estimated to be killing upwards of 100,000 people annually. Snakebite is associated with a diverse pathophysiology due to the magnitude of variation in venom composition that is observed worldwide.
Harry F. Williams, Paul Hayter, Divyashree Ravishankar, Anthony Baines, Harry J. Layfield, Lorraine Croucher, Catherine Wark, Andrew B. Bicknell, Steven Trim, Sakthivel Vaiyapuri   +9 more
doaj   +1 more source

An in vitro α-neurotoxin-nAChR binding assay correlates with lethality and in vivo neutralization of a large number of elapid neurotoxic snake venoms from four continents.

PLoS Neglected Tropical Diseases, 2020
The aim of this study was to develop an in vitro assay for use in place of in vivo assays of snake venom lethality and antivenom neutralizing potency.
Kritsada Pruksaphon, Kae Yi Tan, Choo Hock Tan, Pavinee Simsiriwong, José María Gutiérrez, Kavi Ratanabanangkoon   +5 more
doaj   +1 more source

Evaluation of Antifungal Activity of Naja pallida and Naja mossambica Venoms against Three Candida Species

Toxins, 2020
In contrast to comprehensively investigated antibacterial activity of snake venoms, namely crude venoms and their selected components, little is known about antifungal properties of elapid snake venoms. In the present study, the proteome of two venoms of
Ewelina Kuna, Aleksandra Bocian, Konrad K. Hus, Vladimir Petrilla, Monika Petrillova, Jaroslav Legath, Anna Lewinska, Maciej Wnuk   +7 more
doaj   +1 more source

Engineered nanoparticles bind elapid snake venom toxins and inhibit venom-induced dermonecrosis

PLOS Neglected Tropical Diseases, 2018
Envenomings by snakebites constitute a serious and challenging global health issue. The mainstay in the therapy of snakebite envenomings is the parenteral administration of animal-derived antivenoms. Significantly, antivenoms are only partially effective in the control of local tissue damage. A novel approach to mitigate the progression of local tissue
Jeffrey O’Brien, Shih-Hui Lee, José María Gutiérrez, Kenneth J. Shea   +3 more
openaire   +6 more sources

Two pathways for venom toxin entry consequent to injection of an Australian elapid snake venom [PDF]

Scientific Reports, 2019
AbstractHere we test and refute the hypothesis that venom toxins from an Australian elapid, the Eastern Brown snake (Pseudonaja textilis, PTx), solely require lymphatic transport to enter the circulation. Studies were made using anaesthetised non-recovery rats in which a marker dye (India ink) or highly potent PTx venom was injected into the hind paw ...
Dirk F. van Helden, Peter J. Dosen, Margaret A. O’Leary, Geoffrey K. Isbister   +3 more
openaire   +2 more sources

The venom gland transcriptome of the Desert Massasauga Rattlesnake (): towards an understanding of venom composition among advanced snakes (Superfamily Colubroidea) [PDF]

, 2007
BACKGROUND: Snake venoms are complex mixtures of pharmacologically active proteins and peptides which belong to a small number of superfamilies. Global cataloguing of the venom transcriptome facilitates the identification of new families of toxins as ...
Kini, R. Manjunatha, Mackessy, Stephen P., Pahari, Susanta   +2 more
core   +4 more sources

Full-Length Venom Protein cDNA Sequences from Venom-Derived mRNA: Exploring Compositional Variation and Adaptive Multigene Evolution. [PDF]

PLoS Neglected Tropical Diseases, 2016
Envenomation of humans by snakes is a complex and continuously evolving medical emergency, and treatment is made that much more difficult by the diverse biochemical composition of many venoms.
Cassandra M Modahl, Stephen P Mackessy
doaj   +1 more source

Inventing an arsenal: adaptive evolution and neofunctionalization of snake venom phospholipase A genes [PDF]

, 2007
Background Gene duplication followed by functional divergence has long been hypothesized to be the main source of molecular novelty. Convincing examples of neofunctionalization, however, remain rare.
Lynch Vincent J
core   +1 more source