Results 21 to 30 of about 11,707 (151)

An in vitro α-neurotoxin-nAChR binding assay correlates with lethality and in vivo neutralization of a large number of elapid neurotoxic snake venoms from four continents. [PDF]

PLoS Neglected Tropical Diseases, 2020
The aim of this study was to develop an in vitro assay for use in place of in vivo assays of snake venom lethality and antivenom neutralizing potency.
Kritsada Pruksaphon, Kae Yi Tan, Choo Hock Tan, Pavinee Simsiriwong, José María Gutiérrez, Kavi Ratanabanangkoon   +5 more
doaj   +2 more sources

Protease Activity Profiling of Snake Venoms Using High-Throughput Peptide Screening [PDF]

Toxins, 2019
Snake venom metalloproteinases (SVMPs) and snake venom serine proteinases (SVSPs) are among the most abundant enzymes in many snake venoms, particularly among viperids. These proteinases are responsible for some of the clinical manifestations classically
Konstantinos Kalogeropoulos, Andreas Frederik Treschow, Ulrich auf dem Keller, Teresa Escalante, Alexandra Rucavado, José María Gutiérrez, Andreas Hougaard Laustsen, Christopher T. Workman   +7 more
doaj   +2 more sources

Evaluation of Antifungal Activity of Naja pallida and Naja mossambica Venoms against Three Candida Species

Toxins, 2020
In contrast to comprehensively investigated antibacterial activity of snake venoms, namely crude venoms and their selected components, little is known about antifungal properties of elapid snake venoms. In the present study, the proteome of two venoms of
Ewelina Kuna, Aleksandra Bocian, Konrad K. Hus, Vladimir Petrilla, Monika Petrillova, Jaroslav Legath, Anna Lewinska, Maciej Wnuk   +7 more
doaj   +2 more sources

Parallel in vitro ion channel and in vivo zebrafish assaying of elapid snake venoms following chromatographic separation of toxin components [PDF]

SLAS Discovery
Snake venoms are complex bioactive mixtures designed to paralyse, kill, or digest prey. These venoms are of pharmacological interest due to their ability to modulate molecular targets such as ion channels and receptors with high specificity and potency ...
Arif Arrahman, Haifeng Xu, Muzaffar A. Khan, Tijmen S. Bos, Julien Slagboom, Guus C. van der Velden, Ulrike Nehrdich, Nicholas R. Casewell, Michael K. Richardson, Christian Tudorache, Fernanda C. Cardoso, Jeroen Kool   +11 more
doaj   +2 more sources

Neutralization of the Principal Toxins from the Venoms of Thai Naja kaouthia and Malaysian Hydrophis schistosus: Insights into Toxin-Specific Neutralization by Two Different Antivenoms

Toxins, 2016
Antivenom neutralization against cobra venoms is generally low in potency, presumably due to poor toxin-specific immunoreactivity. This study aimed to investigate the effectiveness of two elapid antivenoms to neutralize the principal toxins purified from
Kae Yi Tan, Choo Hock Tan, Shin Yee Fung, Nget Hong Tan   +3 more
doaj   +2 more sources

Inflammation induced by snake venoms optimizes envenomation. [PDF]

J Physiol
Abstract figure legend Schematic illustrating mechanisms underlying direct vascular absorption and subsequent movement of venom toxins into the tissues consequent to snakebite. A, snakebite into prey deposits venom toxins into the tissue interstitium, with the venom then causing acute inflammation primarily in venules.
van Helden DF, Spratt N, Dosen PJ, McFadden SA, Holdsworth J, Beard DJ, Coupland K, Jobling P, Hardy TA, Laver DR.   +9 more
europepmc   +2 more sources

Immunological Cross-Reactivity and Neutralizing Efficacy of Antivenom Against Five Medically Important Iranian Viper Venoms. [PDF]

Vet Med Sci
Investigating Iranian viper venoms reveals compositional and antigenic diversity impacting antivenom efficacy. The study highlights the need to incorporate both broadly cross‐reactive and specifically under‐represented venoms into immunization mixtures to optimize paraspecific protection strategies.
Khamehchian S, Tahoori F, Rabie H, Nasrabadi NN, Tebianian M.   +4 more
europepmc   +2 more sources

Crystal structure and functional characterization of an Asp49 phospholipase A₂ from the bushmaster (Lachesis muta). [PDF]

Acta Crystallogr F Struct Biol Commun
The crystal structure of an Asp49 phospholipase A2 from L. muta is reported, revealing a tetrameric assembly, catalytic conservation and a polarized electrostatic surface potentially linked to membrane targeting.Snake‐venom phospholipases A2 (PLA2s) are small, structurally conserved enzymes that contribute significantly to the pathophysiology of ...
Neyra Chama NE, Romero Vargas FF, Condori Mamani E, Vargas JA, Alves Furtado A, D'Muniz Pereira H, Navarro Oviedo RD, Garratt RC, Vega Ramírez JLJ, Leonardo DA.   +9 more
europepmc   +2 more sources

Polyvalent Snake Antivenoms: Production Strategy and Their Therapeutic Benefits

Toxins, 2023
Snake envenomation remains an important yet neglected medical problem in many countries, with around five million people affected, and over a hundred thousand deaths annually. Plasma-derived antivenoms are the main therapeutic agent available. Monovalent
Kavi Ratanabanangkoon
doaj   +1 more source

Comparative venom toxin analyses of Nigerian viperidae and elapidae snakes

Scientific African, 2023
Envenoming by snakebite is a serious health problem that maims and kills a large number of people, primarily in rural areas of developing African countries. The first comparative venom proteomic analyses of four snakes from the viperidae (E.
Fatima Amin Adamude, Emeka John Dingwoke, Mujitaba Suleiman Abubakar, Gadija Mohamed, Ashwil Klein, Abdullahi Balarabe Sallau   +5 more
doaj   +1 more source