Results 21 to 30 of about 1,869 (190)
Parallel in vitro ion channel and in vivo zebrafish assaying of elapid snake venoms following chromatographic separation of toxin components [PDF]
SLAS DiscoverySnake venoms are complex bioactive mixtures designed to paralyse, kill, or digest prey. These venoms are of pharmacological interest due to their ability to modulate molecular targets such as ion channels and receptors with high specificity and potency ...
Arif Arrahman +11 more
doaj +2 more sources
Impact of Naja nigricollis Venom on the Production of Methaemoglobin [PDF]
Toxins, 2018 Snakebite envenomation is an affliction currently estimated to be killing upwards of 100,000 people annually. Snakebite is associated with a diverse pathophysiology due to the magnitude of variation in venom composition that is observed worldwide.
Harry F. Williams +9 more
doaj +2 more sources
Assessing the Utility of Broad-Acting Inhibitors as Therapeutics in Diverse Venoms [PDF]
ToxinsExamination of venom constituent bioactivities from diverse venomous animals shows certain highly conserved classes, including enzymes (e.g., phospholipases and metalloproteinases) and pore-forming proteins.
Raechel Kadler +2 more
doaj +2 more sources
Toxins, 2020 In contrast to comprehensively investigated antibacterial activity of snake venoms, namely crude venoms and their selected components, little is known about antifungal properties of elapid snake venoms. In the present study, the proteome of two venoms of
Ewelina Kuna +7 more
doaj +2 more sources
Toxins, 2016 Antivenom neutralization against cobra venoms is generally low in potency, presumably due to poor toxin-specific immunoreactivity. This study aimed to investigate the effectiveness of two elapid antivenoms to neutralize the principal toxins purified from
Kae Yi Tan +3 more
doaj +2 more sources
Cloning and characterisation of novel cystatins from elapid snake venom glands
Biochimie, 2011 Snake venoms contain a complex mixture of polypeptides that modulate prey homeostatic mechanisms through highly specific and targeted interactions. In this study we have identified and characterised cystatin-like cysteine-protease inhibitors from elapid snake venoms for the first time.
Richards, Renee +6 more
openaire +6 more sources
Pro-inflammatory activities in elapid snake venoms [PDF]
Toxicon, 1994 Snake venoms from the genera Micrurus (M. ibiboboca and M. spixii) and Naja (N. naja, N. melanoleuca and N. nigricollis) were analysed, using biological and immunochemical methods, to detect pro‐inflammatory activities, cobra venom factor (COF), proteolytic enzymes, thrombin‐like substances, haemorrhagic and oedema‐producing substances.
D V, Tambourgi +5 more
openaire +2 more sources
PLoS Neglected Tropical Diseases, 2021 Development of a rapid, on-site detection tool for snakebite is highly sought after, owing to its clinically and forensically relevant medicolegal significance.
Sherin Kaul +6 more
doaj +1 more source
Polyvalent Snake Antivenoms: Production Strategy and Their Therapeutic Benefits
Toxins, 2023 Snake envenomation remains an important yet neglected medical problem in many countries, with around five million people affected, and over a hundred thousand deaths annually. Plasma-derived antivenoms are the main therapeutic agent available. Monovalent
Kavi Ratanabanangkoon
doaj +1 more source
Comparative venom toxin analyses of Nigerian viperidae and elapidae snakes
Scientific African, 2023 Envenoming by snakebite is a serious health problem that maims and kills a large number of people, primarily in rural areas of developing African countries. The first comparative venom proteomic analyses of four snakes from the viperidae (E.
Fatima Amin Adamude +5 more
doaj +1 more source