Results 31 to 40 of about 11,707 (151)

Engineering Antivenom: Research Progress and Future Directions in Snakebite Envenoming Therapy. [PDF]

Ann N Y Acad Sci
Snakebite envenoming therapy is evolving from plasma‐derived antivenoms toward rationally engineered therapeutics. Advances in toxicovenomics, structural biology, antibody engineering, computational protein design, recombinant expression, small‐molecule inhibitors, and diagnostics are enabling toxin‐centric development of safer, more effective, and ...
Laustsen AH.
europepmc   +2 more sources

Snake Venom Protease Detection and Inhibition in Serum. [PDF]

ChemMedChem
A fluorescence assay enables sensitive detection of the activities of snake venom metalloproteases (SVMP) and serine proteases (SVSP) from viper venoms in buffer and serum. In combination with effective low‐molecular‐weight inhibitors such as ilomastat and nafamostat, this approach offers new prospects for the rapid diagnosis and adjunctive therapy of ...
Riedel M, Kersten C.
europepmc   +2 more sources

Investigating Toxin Diversity and Abundance in Snake Venom Proteomes

Frontiers in Pharmacology, 2022
Understanding snake venom proteomes is becoming increasingly important to understand snake venom biology, evolution and especially clinical effects of venoms and approaches to antivenom development.
Theo Tasoulis, Tara L. Pukala, Geoffrey K. Isbister   +2 more
doaj   +1 more source

Brightfield microscopy images of RPTEC/TERT1 cells in response to three different venoms, which were used to quantify the cell surface area.

, 2023
Conditions shown for three different venoms: cytotoxic viper, cytotoxic elapid and non-cytotoxic elapid. Top row represents the ‘training’ of the software to differentiate cell populations (red dots) from the ‘empty well area’ (green dots) using a simple
Nicholas R. Casewell (7062380), Matyas A. Bittenbinder (11784741), Bas van de Velde (16846520), Paul Jennings (562110), Liliana Capinha (16846517), Daniel Da Costa Pereira (4962769), Julien Slagboom (7062371), Jeroen Kool (1778482), Freek J. Vonk (11726221)   +8 more
core   +1 more source

Virus-like particles displaying conserved toxin epitopes stimulate polyspecific, murine antibody responses capable of snake venom recognition

Scientific Reports, 2022
Antivenom is currently the first-choice treatment for snakebite envenoming. However, only a low proportion of antivenom immunoglobulins are specific to venom toxins, resulting in poor dose efficacy and potency.
Stefanie K. Menzies, Charlotte A. Dawson, Edouard Crittenden, Rebecca J. Edge, Steven R. Hall, Jaffer Alsolaiss, Mark C. Wilkinson, Nicholas R. Casewell, Robert A. Harrison, Stuart Ainsworth   +9 more
doaj   +1 more source

Anticoagulant Activity of Naja nigricollis Venom Is Mediated by Phospholipase A2 Toxins and Inhibited by Varespladib

Toxins, 2021
Bites from elapid snakes typically result in neurotoxic symptoms in snakebite victims. Neurotoxins are, therefore, often the focus of research relating to understanding the pathogenesis of elapid bites.
Taline D. Kazandjian, Arif Arrahman, Kristina B. M. Still, Govert W. Somsen, Freek J. Vonk, Nicholas R. Casewell, Mark C. Wilkinson, Jeroen Kool   +7 more
doaj   +1 more source

Mean antibody titer of ‘pan-specific’ antiserum (pAS) against homologous elapid venoms.

, 2016
Mean antibody titer of ‘pan-specific’ antiserum (pAS) against homologous elapid venoms.
Sukanya Eursakun (3174869), Choo Hock Tan (573250), Teeraporn Pamornsakda (3174878), Witthawat Wiriyarat (119671), Pavinee Simsiriwong (3174872), Kae Yi Tan (3174875), Nget Hong Tan (320262), Kavi Ratanabanangkoon (702432), Chaiya Klinpayom (3174881)   +8 more
core   +1 more source

Full-Length Venom Protein cDNA Sequences from Venom-Derived mRNA: Exploring Compositional Variation and Adaptive Multigene Evolution. [PDF]

PLoS Neglected Tropical Diseases, 2016
Envenomation of humans by snakes is a complex and continuously evolving medical emergency, and treatment is made that much more difficult by the diverse biochemical composition of many venoms.
Cassandra M Modahl, Stephen P Mackessy
doaj   +1 more source

Mean antibody titer of ‘pan-specific antiserum’ (pAS) against heterologous elapid venoms.

, 2016
Mean antibody titer of ‘pan-specific antiserum’ (pAS) against heterologous elapid venoms.
Sukanya Eursakun (3174869), Choo Hock Tan (573250), Teeraporn Pamornsakda (3174878), Witthawat Wiriyarat (119671), Pavinee Simsiriwong (3174872), Kae Yi Tan (3174875), Nget Hong Tan (320262), Kavi Ratanabanangkoon (702432), Chaiya Klinpayom (3174881)   +8 more
core   +1 more source

Comparison of lethality of crude venoms and toxin fractions (TF) of four elapid snakes.

, 2016
Comparison of lethality of crude venoms and toxin fractions (TF) of four elapid snakes.
Sukanya Eursakun (3174869), Choo Hock Tan (573250), Teeraporn Pamornsakda (3174878), Witthawat Wiriyarat (119671), Pavinee Simsiriwong (3174872), Kae Yi Tan (3174875), Nget Hong Tan (320262), Kavi Ratanabanangkoon (702432), Chaiya Klinpayom (3174881)   +8 more
core   +1 more source