Results 31 to 40 of about 1,869 (190)
Frontiers in Pharmacology, 2023 Introduction: Most elapid snakes produce venoms that contain alpha-neurotoxins (α-NTXs), which are proteins that cause post-synaptic blockade and paralysis in snakebite envenoming.
Yi Wei Chan +3 more
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Investigating Toxin Diversity and Abundance in Snake Venom Proteomes
Frontiers in Pharmacology, 2022 Understanding snake venom proteomes is becoming increasingly important to understand snake venom biology, evolution and especially clinical effects of venoms and approaches to antivenom development.
Theo Tasoulis +2 more
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Elapid venom toxins: multiple recruitments of ancient scaffolds [PDF]
European Journal of Biochemistry, 1999 Nigroxins A and B, two myotoxic phospholipases A2 (PLA2s) from the venom of the American elapid Micrurus nigrocinctus, belong to a new PLA2 subclass. Their primary structures were established and compared with those of PLA2s that have already been studied with respect to myotoxic activity.
Alape Girón, Alberto +7 more
openaire +4 more sources
Comparative Analysis of Prothrombin Activators from the Venom of Australian Elapids [PDF]
Molecular Biology and Evolution, 2005 A key component of the venom of many Australian snakes belonging to the elapid family is a toxin that is structurally and functionally similar to that of the mammalian prothrombinase complex. In mammals, this complex is responsible for the cleavage of prothrombin to thrombin and is composed of factor Xa in association with its cofactors calcium ...
St. Pierre, Liam +6 more
openaire +5 more sources
Two pathways for venom toxin entry consequent to injection of an Australian elapid snake venom [PDF]
Scientific Reports, 2019 AbstractHere we test and refute the hypothesis that venom toxins from an Australian elapid, the Eastern Brown snake (Pseudonaja textilis, PTx), solely require lymphatic transport to enter the circulation. Studies were made using anaesthetised non-recovery rats in which a marker dye (India ink) or highly potent PTx venom was injected into the hind paw ...
Dirk F. van Helden +3 more
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Scientific Reports, 2022 Antivenom is currently the first-choice treatment for snakebite envenoming. However, only a low proportion of antivenom immunoglobulins are specific to venom toxins, resulting in poor dose efficacy and potency.
Stefanie K. Menzies +9 more
doaj +1 more source
Toxins, 2021 Bites from elapid snakes typically result in neurotoxic symptoms in snakebite victims. Neurotoxins are, therefore, often the focus of research relating to understanding the pathogenesis of elapid bites.
Taline D. Kazandjian +7 more
doaj +1 more source
Full-Length Venom Protein cDNA Sequences from Venom-Derived mRNA: Exploring Compositional Variation and Adaptive Multigene Evolution. [PDF]
PLoS Neglected Tropical Diseases, 2016 Envenomation of humans by snakes is a complex and continuously evolving medical emergency, and treatment is made that much more difficult by the diverse biochemical composition of many venoms.
Cassandra M Modahl, Stephen P Mackessy
doaj +1 more source
Toxinology of Venoms from Five Australian Lesser Known Elapid Snakes [PDF]
Basic & Clinical Pharmacology & Toxicology, 2012 AbstractResearch into Australian elapid venoms has mainly focused on the seven genera of greatest clinical significance: Acanthophis, Hoplocephalus, Notechis, Oxyuranus, Pseudechis, Pseudonaja and Tropidechis. However, even small species represent a potential for causing severe clinical envenoming.
Pycroft, Kyle +6 more
openaire +5 more sources
Mean antibody titer of ‘pan-specific’ antiserum (pAS) against homologous elapid venoms.
, 2016 Mean antibody titer of ‘pan-specific’ antiserum (pAS) against homologous elapid venoms.
Sukanya Eursakun (3174869) +8 more
core +1 more source