Results 11 to 20 of about 1,625 (162)

Venom Down Under: Dynamic Evolution of Australian Elapid Snake Toxins [PDF]

Toxins, 2013
Despite the unparalleled diversity of venomous snakes in Australia, research has concentrated on a handful of medically significant species and even of these very few toxins have been fully sequenced.
Timothy N. W. Jackson, Kartik Sunagar, Eivind A. B. Undheim, Ivan Koludarov, Angelo H. C. Chan, Kate Sanders, Syed A. Ali, Iwan Hendrikx, Nathan Dunstan, Bryan G. Fry   +9 more
doaj   +6 more sources

Assessing the Utility of Broad-Acting Inhibitors as Therapeutics in Diverse Venoms [PDF]

Toxins
Examination of venom constituent bioactivities from diverse venomous animals shows certain highly conserved classes, including enzymes (e.g., phospholipases and metalloproteinases) and pore-forming proteins.
Raechel Kadler, Breanna Morrison, Angel Anne Yanagihara   +2 more
doaj   +2 more sources

Transcriptomic Insights Into the Evolution of Snake Venom: Mechanisms, Diversity, and Adaptation. [PDF]

Scientifica (Cairo)
Snake venoms are evolutionarily refined biochemical arsenals composed of diverse toxins with complex functional roles in predation, defense, and competition. Over the past 2 decades, transcriptomic approaches have transformed venom research by enabling high‐resolution insights into gene expression dynamics, molecular diversity, and the evolutionary ...
Sofyantoro F, Kusuma WA, Wahyudi ST, Lumbanraja FR, Rahmawan H, Rustamaji HC, Kurniawan DW, Rastuti U, Putri WA, Wibowo WA, Priyono DS, Yudha DS, Raharjo S, Nuringtyas TR.   +13 more
europepmc   +2 more sources

Application of an Extracellular Matrix-Mimicking Fluorescent Polymer for the Detection of Proteolytic Venom Toxins

Toxins, 2023
The cytotoxicity caused by snake venoms is a serious medical problem that greatly contributes to the morbidity observed in snakebite patients. The cytotoxic components found in snake venoms belong to a variety of toxin classes and may cause cytotoxic ...
Eric Wachtel, Matyas A. Bittenbinder, Bas van de Velde, Julien Slagboom, Axel de Monts de Savasse, Luis L. Alonso, Nicholas R. Casewell, Freek J. Vonk, Jeroen Kool   +8 more
doaj   +1 more source

Pro-inflammatory activities in elapid snake venoms [PDF]

Toxicon, 1994
Snake venoms from the genera Micrurus (M. ibiboboca and M. spixii) and Naja (N. naja, N. melanoleuca and N. nigricollis) were analysed, using biological and immunochemical methods, to detect pro‐inflammatory activities, cobra venom factor (COF), proteolytic enzymes, thrombin‐like substances, haemorrhagic and oedema‐producing substances.
D V, Tambourgi, M C, dos Santos, M de F, Furtado, M C, de Freitas, W D, da Silva, T L, Kipnis   +5 more
openaire   +2 more sources

Cytotoxin antibody-based colourimetric sensor for field-level differential detection of elapid among big four snake venom.

PLoS Neglected Tropical Diseases, 2021
Development of a rapid, on-site detection tool for snakebite is highly sought after, owing to its clinically and forensically relevant medicolegal significance.
Sherin Kaul, L Sai Keerthana, Pankaj Kumar, Komal Birader, Yathirajarao Tammineni, Deepali Rawat, Pankaj Suman   +6 more
doaj   +1 more source

Polyvalent Snake Antivenoms: Production Strategy and Their Therapeutic Benefits

Toxins, 2023
Snake envenomation remains an important yet neglected medical problem in many countries, with around five million people affected, and over a hundred thousand deaths annually. Plasma-derived antivenoms are the main therapeutic agent available. Monovalent
Kavi Ratanabanangkoon
doaj   +1 more source

A Combined Bioassay and Nanofractionation Approach to Investigate the Anticoagulant Toxins of Mamba and Cobra Venoms and Their Inhibition by Varespladib

Toxins, 2022
Envenomation by elapid snakes primarily results in neurotoxic symptoms and, consequently, are the primary focus of therapeutic research concerning such venoms. However, mounting evidence suggests these venoms can additionally cause coagulopathic symptoms,
Arif Arrahman, Taline D. Kazandjian, Kristina B. M. Still, Julien Slagboom, Govert W. Somsen, Freek J. Vonk, Nicholas R. Casewell, Jeroen Kool   +7 more
doaj   +1 more source

Comparative venom toxin analyses of Nigerian viperidae and elapidae snakes

Scientific African, 2023
Envenoming by snakebite is a serious health problem that maims and kills a large number of people, primarily in rural areas of developing African countries. The first comparative venom proteomic analyses of four snakes from the viperidae (E.
Fatima Amin Adamude, Emeka John Dingwoke, Mujitaba Suleiman Abubakar, Gadija Mohamed, Ashwil Klein, Abdullahi Balarabe Sallau   +5 more
doaj   +1 more source

An immunoinformatic approach to assessing the immunogenic capacity of alpha-neurotoxins in elapid snake venoms

Frontiers in Pharmacology, 2023
Introduction: Most elapid snakes produce venoms that contain alpha-neurotoxins (α-NTXs), which are proteins that cause post-synaptic blockade and paralysis in snakebite envenoming.
Yi Wei Chan, Choo Hock Tan, Choon Han Heh, Kae Yi Tan   +3 more
doaj   +1 more source