PLoS Neglected Tropical Diseases, 2016 Snakebite envenomation is a serious medical problem in many tropical developing countries and was considered by WHO as a neglected tropical disease.
Kavi Ratanabanangkoon +8 more
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Polyamines as Snake Toxins and Their Probable Pharmacological Functions in Envenomation
Toxins, 2016 While decades of research have focused on snake venom proteins, far less attention has been paid to small organic venom constituents. Using mostly pooled samples, we surveyed 31 venoms (six elapid, six viperid, and 19 crotalid) for spermine, spermidine ...
Steven D. Aird +3 more
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Snake Venom Protease Detection and Inhibition in Serum. [PDF]
ChemMedChemA fluorescence assay enables sensitive detection of the activities of snake venom metalloproteases (SVMP) and serine proteases (SVSP) from viper venoms in buffer and serum. In combination with effective low‐molecular‐weight inhibitors such as ilomastat and nafamostat, this approach offers new prospects for the rapid diagnosis and adjunctive therapy of ...
Riedel M, Kersten C.
europepmc +2 more sources
Application of an Extracellular Matrix-Mimicking Fluorescent Polymer for the Detection of Proteolytic Venom Toxins [PDF]
Toxins, 2023 The cytotoxicity caused by snake venoms is a serious medical problem that greatly contributes to the morbidity observed in snakebite patients. The cytotoxic components found in snake venoms belong to a variety of toxin classes and may cause cytotoxic ...
Eric Wachtel +8 more
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Profiling cytotoxicity of nanofractionated elapid snake venoms in human cell lines representing different tissues [PDF]
Journal of Pharmaceutical AnalysisElapid snakebites cause severe toxicity, predominantly neurotoxicity and general cytotoxicity. However, the specific cellular impacts of individual venom toxins remain largely underexplored.
Haifeng Xu +5 more
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PLoS Neglected Tropical Diseases, 2020 The aim of this study was to develop an in vitro assay for use in place of in vivo assays of snake venom lethality and antivenom neutralizing potency.
Kritsada Pruksaphon +5 more
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Cross neutralization of Afro-Asian cobra and Asian krait venoms by a Thai polyvalent snake antivenom (Neuro Polyvalent Snake Antivenom). [PDF]
PLoS Neglected Tropical Diseases, 2012 BACKGROUND: Snake envenomation is a serious public health threat in the rural areas of Asian and African countries. To date, the only proven treatment for snake envenomation is antivenom therapy.
Poh Kuan Leong +5 more
doaj +4 more sources
Coral snake venoms: mode of action and pathophysiology of experimental envenomation [PDF]
Revista do Instituto de Medicina Tropical de São Paulo, 1987 Coral snakes, the New World Elapidae, are included in the genera Micniroides and Micrurus. The genus Mlcrurus comprises nearly all coral snake species and those which are responsible for human snake-bite accidents.
Oswald Vital Brazil
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A polygeneric immunogen composed of 22 venoms from sub-Saharan African snakes to expand the neutralization scope of the EchiTAb-plus-ICP antivenom [PDF]
Toxicon: XRecent research suggests that a polygeneric immunogen made from the venoms of the most medically important viperid and elapid snakes in sub-Saharan Africa could elicit a broader antibody response in horses compared to the current EchiTAb-plus-ICP ...
Andrés Sánchez +16 more
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Protease Activity Profiling of Snake Venoms Using High-Throughput Peptide Screening [PDF]
Toxins, 2019 Snake venom metalloproteinases (SVMPs) and snake venom serine proteinases (SVSPs) are among the most abundant enzymes in many snake venoms, particularly among viperids. These proteinases are responsible for some of the clinical manifestations classically
Konstantinos Kalogeropoulos +7 more
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