Results 11 to 20 of about 11,707 (151)

Evidence for Resistance to Coagulotoxic Effects of Australian Elapid Snake Venoms by Sympatric Prey (Blue Tongue Skinks) but Not by Predators (Monitor Lizards)

Toxins, 2021
Some Australian elapids possess potently procoagulant coagulotoxic venoms which activate the zymogen prothrombin into the functional enzyme thrombin. Although the activity of Australian elapid prothrombin-activators has been heavily investigated with ...
Nicholas J. Youngman, Joshua Llinas, Bryan G. Fry   +2 more
doaj   +2 more sources

Elapid Snake Venom Analyses Show the Specificity of the Peptide Composition at the Level of Genera Naja and Notechis

Toxins, 2014
Elapid snake venom is a highly valuable, but till now mainly unexplored, source of pharmacologically important peptides. We analyzed the peptide fractions with molecular masses up to 10 kDa of two elapid snake venoms—that of the African cobra, N.
Aisha Munawar, Maria Trusch, Dessislava Georgieva, Diana Hildebrand, Marcel Kwiatkowski, Henning Behnken, Sönke Harder, Raghuvir Arni, Patrick Spencer, Hartmut Schlüter, Christian Betzel   +10 more
doaj   +2 more sources

An immunoinformatic approach to assessing the immunogenic capacity of alpha-neurotoxins in elapid snake venoms

Frontiers in Pharmacology, 2023
Introduction: Most elapid snakes produce venoms that contain alpha-neurotoxins (α-NTXs), which are proteins that cause post-synaptic blockade and paralysis in snakebite envenoming.
Yi Wei Chan, Choo Hock Tan, Choon Han Heh, Kae Yi Tan   +3 more
doaj   +2 more sources

A Combined Bioassay and Nanofractionation Approach to Investigate the Anticoagulant Toxins of Mamba and Cobra Venoms and Their Inhibition by Varespladib [PDF]

Toxins, 2022
Envenomation by elapid snakes primarily results in neurotoxic symptoms and, consequently, are the primary focus of therapeutic research concerning such venoms. However, mounting evidence suggests these venoms can additionally cause coagulopathic symptoms,
Arif Arrahman, Taline D. Kazandjian, Kristina B. M. Still, Julien Slagboom, Govert W. Somsen, Freek J. Vonk, Nicholas R. Casewell, Jeroen Kool   +7 more
doaj   +2 more sources

From Venom to Vein: Factor VII Activation as a Major Pathophysiological Target for Procoagulant Australian Elapid Snake Venoms

Toxins
Australian elapid snake venoms are uniquely procoagulant, utilizing blood clotting enzyme Factor Xa (FXa) as a toxin, which evolved as a basal trait in this clade.
Uthpala Chandrasekara, Abhinandan Chowdhury, Lorenzo Seneci, Christina N. Zdenek, Nathan Dunstan, Bryan G. Fry   +5 more
doaj   +2 more sources

Coral snake venoms: mode of action and pathophysiology of experimental envenomation [PDF]

Revista do Instituto de Medicina Tropical de São Paulo, 1987
Coral snakes, the New World Elapidae, are included in the genera Micniroides and Micrurus. The genus Mlcrurus comprises nearly all coral snake species and those which are responsible for human snake-bite accidents.
Oswald Vital Brazil
doaj   +2 more sources

Cross neutralization of Afro-Asian cobra and Asian krait venoms by a Thai polyvalent snake antivenom (Neuro Polyvalent Snake Antivenom). [PDF]

PLoS Neglected Tropical Diseases, 2012
BACKGROUND: Snake envenomation is a serious public health threat in the rural areas of Asian and African countries. To date, the only proven treatment for snake envenomation is antivenom therapy.
Poh Kuan Leong, Si Mui Sim, Shin Yee Fung, Khomvilai Sumana, Visith Sitprija, Nget Hong Tan   +5 more
doaj   +4 more sources

A Simple and Novel Strategy for the Production of a Pan-specific Antiserum against Elapid Snakes of Asia.

PLoS Neglected Tropical Diseases, 2016
Snakebite envenomation is a serious medical problem in many tropical developing countries and was considered by WHO as a neglected tropical disease.
Kavi Ratanabanangkoon, Kae Yi Tan, Sukanya Eursakun, Choo Hock Tan, Pavinee Simsiriwong, Teeraporn Pamornsakda, Witthawat Wiriyarat, Chaiya Klinpayom, Nget Hong Tan   +8 more
doaj   +2 more sources

Polyamines as Snake Toxins and Their Probable Pharmacological Functions in Envenomation

Toxins, 2016
While decades of research have focused on snake venom proteins, far less attention has been paid to small organic venom constituents. Using mostly pooled samples, we surveyed 31 venoms (six elapid, six viperid, and 19 crotalid) for spermine, spermidine ...
Steven D. Aird, Alejandro Villar Briones, Michael C. Roy, Alexander S. Mikheyev   +3 more
doaj   +2 more sources

Impact of Naja nigricollis Venom on the Production of Methaemoglobin [PDF]

Toxins, 2018
Snakebite envenomation is an affliction currently estimated to be killing upwards of 100,000 people annually. Snakebite is associated with a diverse pathophysiology due to the magnitude of variation in venom composition that is observed worldwide.
Harry F. Williams, Paul Hayter, Divyashree Ravishankar, Anthony Baines, Harry J. Layfield, Lorraine Croucher, Catherine Wark, Andrew B. Bicknell, Steven Trim, Sakthivel Vaiyapuri   +9 more
doaj   +2 more sources