Results 61 to 70 of about 26,313 (264)

A Rapid and International Applicable Diagnostic Device for Cobra (Genus Naja) Snakebites

Toxins, 2020
Cobra snakes (genus Naja) are some of the most dangerous snake species in Asia and Africa, as their bites cause severe life-threatening respiratory failure and local tissue destruction, especially in the case of late diagnosis. The differential diagnosis
Jing-Hua Lin, Wang-Chou Sung, Jiunn-Wang Liao, Dong-Zong Hung   +3 more
doaj   +1 more source

Identification and management of Snake Bite in Asia: A narrative review

Journal of the Scientific Society, 2023
Snake bites are an important cause of illness and deaths in the rural population in tropical, subtropical and southeast Asian countries. There are more than 3000 species of snakes found all over the world of which around 300 species are found in India ...
M Rathinasamy, M Mithuna, Sunitha Ramasamy, J Antony, V Jaishree, M Alexander   +5 more
doaj   +1 more source

Recognition of glycine versus non‐glycine citrulline motifs dictates the HLA class II association of anti‐citrullinated protein antibodies ‐ insights from autoantibody profiling of 6900 Scandinavian rheumatoid arthritis patients

Arthritis &Rheumatology, Accepted Article.
Objectives Rheumatoid arthritis (RA) associated anti‐citrullinated protein antibodies (ACPA) target various antigens by binding short citrulline‐amino acid motifs, resulting in heterogeneous ACPA‐profiles among patients. Here we analyzed ACPA‐patterns by recognized citrulline‐motifs in relation to the RA risk factors HLA‐DRB1 shared epitope (SE ...
Linda Mathsson Alm, Helga Westerlind, Isabel Gehring, Monika Hansson, Nasim Ghasemzadeh, Jessica Rojas‐Restrepo, Saedis Saevarsdottir, Joe Sexton, Siri Lillegraven, Espen Haavardsholm, Bente Glintborg, Hilde Berner Hammer, Tore K. Kvien, Merete Lund Hetland, Leonid Padyukov, Swedish Rheumatology Quality Register Biobank Study Group (SRQb), The Danish Rheumatologic Biobank Study Group, Oliver Hendricks, Estrid Høgdall, Tue Wenzel Kragstrup, Dorte Vendelbo Jensen, Heidi Lausten Munk, Jens Kristian Pedersen, Torkell Ellingsen, Anne Gitte Loft, Ellen‐Margrethe Hauge, Salome Kristensen, Lene Dreyer, Asta Linauskas, Søren Jacobsen, Johan Askling, Caroline Grönwall   +31 more
wiley   +1 more source

Flux Sampling Suggests Metabolic Signatures of High Antibody‐Producing CHO Cells

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Chinese hamster ovary (CHO) cells remain the industry standard for producing numerous therapeutic proteins, particularly monoclonal antibodies (mAbs). However, achieving higher recombinant protein titers remains an ongoing challenge and a fundamental understanding of the cellular mechanism driving improved bioprocess performance remains ...
Kate E. Meeson, Joanne Watson, Susan Rosser, Ellie Hawke, Andrew Pitt, Tessa Moses, Leon Pybus, Magnus Rattray, Alan J. Dickson, Jean‐Marc Schwartz   +9 more
wiley   +1 more source

Harnessing cell aggregates for enhanced adeno‐associated virus manufacturing: Cultivation strategies and scale‐up considerations

Biotechnology Progress, EarlyView.
Abstract The possibility to produce recombinant adeno‐associated virus (rAAV) by adherent HEK293T cells was studied in a stirred tank bioreactor (STR) culture of cell aggregates. A proof‐of‐concept of rAAV production was successfully demonstrated in a process where single cells were first expanded, then cell aggregates were formed by dilution into a ...
Brian Ladd, Torbjörn Gräslund, Véronique Chotteau   +2 more
wiley   +1 more source

A Comprehensive Review of Intramolecular Hydrosilylation of Alkynes and Alkenes

ChemCatChem, EarlyView.
Intramolecular hydrosilylation is a powerful method for alkenes or alkynes functionalization, and provides easy access to silylated heterocycles. The reaction involves the addition of an Si─H bond to a C─C double or triple bond, usually in the presence of a metal catalyst. This review explores the developments in this methodology, as well as the regio‐
Mathias Reboli, Muriel Durandetti
wiley   +1 more source

Human Monoclonal scFvs that Neutralize Fribrinogenolytic Activity of Kaouthiagin, a Zinc-Metalloproteinase in Cobra (Naja kaouthia) Venom

Toxins, 2018
Snake venom-metalloproteinases (SVMPs) are the primary factors that disturb hemostasis and cause hemorrhage in the venomous snake bitten subjects. Kaouthiagin is a unique SVMP that binds and cleaves von Willebrand factor (vWF) at a specific peptide bond ...
Jirawat Khanongnoi, Siratcha Phanthong, Onrapak Reamtong, Anchalee Tungtronchitr, Wanpen Chaicumpa, Nitat Sookrung   +5 more
doaj   +1 more source

Spatiotemporal distribution of neural crest cells in the common wall lizard Podarcis muralis

Developmental Dynamics, EarlyView.
Abstract Background Neural crest cells (NCCs) are migratory embryonic stem cells that give rise to a diverse set of cell types. Here we describe the dynamic distribution of NCCs in developing embryos of the common wall lizard Podarcis muralis inferred from 10 markers.
Robin Pranter, Nathalie Feiner
wiley   +1 more source

Enucleação em serpente urutu (Bothrops alternatus) no tratamento de endoftalmite decorrente de traumatismo de escama corneal

Ciência Rural, 2014
A urutu, Bothrops alternatus, é uma espécie de serpente peçonhenta da família Viperidae e subfamília Crotalinae. Como em outras espécies, ela pode ser acometida por acidentes ofídicos em algumas situações.
Kelly Cristine de Sousa Pontes, Moacir Carreta Júnior, Luis Eugênio Franklin Augusto   +2 more
doaj   +1 more source

Transition-metal-catalyzed C–H bond activation as a sustainable strategy for the synthesis of fluorinated molecules: an overview

Beilstein Journal of Organic Chemistry, 2023
The last decade has witnessed the emergence of innovative synthetic tools for the synthesis of fluorinated molecules. Among these approaches, the transition-metal-catalyzed functionalization of various scaffolds with a panel of fluorinated groups (XRF, X
Louis Monsigny, Floriane Doche, Tatiana Besset   +2 more
doaj   +1 more source