Results 1 to 10 of about 17,484 (210)
Targeting p35/Cdk5 signalling via CIP-peptide promotes angiogenesis in hypoxia. [PDF]
PLoS ONE, 2013 Cyclin-dependent kinase-5 (Cdk5) is over-expressed in both neurons and microvessels in hypoxic regions of stroke tissue and has a significant pathological role following hyper-phosphorylation leading to calpain-induced cell death.
Alessandra Bosutti +17 more
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ERK MAP kinase activation in spinal cord regulates phosphorylation of Cdk5 at serine 159 and contributes to peripheral inflammation induced pain/hypersensitivity. [PDF]
PLoS ONE, 2014 Cyclin-dependent kinase 5 is a proline-directed serine/threonine kinase and its activity participates in the regulation of nociceptive signaling. Like binding with the activators (P35 or P25), the phosphorylation of Cdk5 plays a critical role in Cdk5 ...
Xiaoqin Zhang +4 more
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生物医学转化, 2022 Objective This study aims to elucidate the underlying mechanism of hyperglycemia induced Alzheimer's disease (AD)-like pathological changes. Methods Thirty Sprague Dawley rats (aged 18 weeks) were randomly divided into one control groups and two ...
Cai Hongbin +7 more
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A kinase of many talents: non-neuronal functions of CDK5 in development and disease [PDF]
Open Biology, 2020 The cyclin-dependent kinase 5 (CDK5) represents an unusual member of the family of cyclin-dependent kinases, which is activated upon binding to non-cyclin p35 and p39 proteins. The role of CDK5 in the nervous system has been very well established.
Samanta Sharma, Piotr Sicinski
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Role of caspases, calpain and cdk5 in ammonia-induced cell death in developing brain cells
Neurobiology of Disease, 2008 Hyperammonemia in neonates and infants causes irreversible damages in the developing CNS due to brain cell loss. Elucidating the mechanisms triggering ammonia-induced cell death in CNS is necessary for the development of neuroprotective strategies.
Laurène Cagnon, Olivier Braissant
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CDK5-mediated phosphorylation and stabilization of TPX2 promotes hepatocellular tumorigenesis
Journal of Experimental & Clinical Cancer Research, 2019 Background CDK5, an atypical member of the CDK family, play a significant role in the tumorigenesis of multiple organ, but CDK5 and its substrates in genesis and development of HCC is still unclear.
Fuqiang Wang +10 more
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Regulation of Sox6 by cyclin dependent kinase 5 in brain. [PDF]
PLoS ONE, 2014 Cyclin dependent kinase 5 (Cdk5) is a proline-directed Ser/Thr kinase involved in various biological functions during normal brain development and neurodegeneration.
Parvathi Rudrabhatla +3 more
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Cancer Cell International, 2019 Background Bridging integrator 1 (BIN1) has showed outstanding tumor-suppressive potential via inhibiting c-MYC-mediated tumorigenesis. However, a frequent phosphorylation of c-MYC at Ser-62 site could block the BIN1/c-MYC interaction and limits the ...
Xiangyu Zhang +8 more
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Active Cdk5 Immunoprecipitation and Kinase Assay
Bio-Protocol, 2017 Cdk5 activity is regulated by the amounts of two activator proteins, p35 and p39 (Tsai et al., 1994; Zheng et al., 1998; Humbert et al., 2000). The p35-Cdk5 and p39-Cdk5 complexes have differing sensitivity to salt and detergent concentrations (Hisanaga ...
Andrew Bankston, Li Ku, Yue Feng
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Regulation of hippocampal and behavioral excitability by cyclin-dependent kinase 5.
PLoS ONE, 2009 Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase that has been implicated in learning, synaptic plasticity, neurotransmission, and numerous neurological disorders.
Ammar H Hawasli +7 more
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