Results 11 to 20 of about 17,484 (210)
Knockdown of Expression of Cdk5 or p35 (a Cdk5 Activator) Results in Podocyte Apoptosis. [PDF]
PLoS ONE, 2016 Podocytes are terminally differentiated glomerular epithelial cells. Podocyte loss has been found in many renal diseases. Cdk5 is a cyclin-dependent protein kinase which is predominantly regulated by p35.
Ya-Li Zheng +11 more
doaj +5 more sources
Searching for novel Cdk5 substrates in brain by comparative phosphoproteomics of wild type and Cdk5-/- mice. [PDF]
PLoS ONE, 2014 Protein phosphorylation is the most common post-translational modification that regulates several pivotal functions in cells. Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase which is mostly active in the nervous system.
Erick Contreras-Vallejos +10 more
doaj +11 more sources
Structural Insights into Cdk5 Activation by a Neuronal Cdk5 Activator [PDF]
Biochemical and Biophysical Research Communications, 2001 Although Cdk5 shows high sequence identity to Cdk1 and Cdk2, it can be fully activated by its neuronal activators p35/p25(nck5a) and p39(nck5ai) in a phosphorylation-independent manner. To understand structural basis of the Cdk5/p25(nck5a) activation, the complex is modelled to assume either an obstructed or an opened conformation based on X-ray ...
Lim, HY +5 more
core +10 more sources
Journal of Biomedical Science, 2021 AbstractCdk5 is a proline-directed serine/threonine protein kinase that governs a variety of cellular processes in neurons, the dysregulation of which compromises normal brain function. The mechanisms underlying the modulation of Cdk5, its modes of action, and its effects on the nervous system have been a great focus in the field for nearly three ...
Pao, Ping-Chieh, Tsai, Li-Huei
openaire +5 more sources
The Structural Perspective on CDK5 [PDF]
Neurosignals, 2003 Cyclin-dependent kinase 5 (CDK5) plays an essential role in the development of the central nervous system during mammalian embryogenesis. In the adult, CDK5 is required for the maintenance of neuronal architecture. Its deregulation has profound cytotoxic effects and has been implicated in the development of neurodegenerative diseases such as Alzheimer ...
Mapelli, Marina, Musacchio, Andrea
openaire +6 more sources
Cdk5 regulates Rap1 activity [PDF]
Neurochemistry International, 2013 Rap1 signaling is important for migration, differentiation, axonal growth, and during neuronal polarity. Rap1 can be activated by external stimuli, which in turn regulates specific guanine nucleotide exchange factors such as C3G, among others. Cdk5 functions are also important to neuronal migration and differentiation.
Utreras Puratich, Elías +7 more
openaire +13 more sources
The Recycling Endosomal (Na<sup>+</sup>, K<sup>+</sup>)/H<sup>+</sup> Exchanger NHE6/SLC9A6 Facilitates Signal Transduction by Shuttling Cyclin-Dependent Kinase 5 to the Plasma Membrane. [PDF]
Acta Physiol (Oxf)ABSTRACT Aim The alkali cation/proton exchanger NHE6/SLC9A6 regulates luminal pH homeostasis and trafficking of recycling endosomes in most tissues, especially neurons. Loss‐of‐function mutations in NHE6 cause Christianson Syndrome, an X‐linked neurodevelopmental and neurodegenerative disorder; however, the underlying molecular and cellular mechanisms ...
Flessner R +6 more
europepmc +2 more sources
Biological functions of CDK5 and potential CDK5 targeted clinical treatments
Oncotarget, 2017 Cyclin dependent kinases are proline-directed serine/threonine protein kinases that are traditionally activated upon association with a regulatory subunit. For most CDKs, activation by a cyclin occurs through association and phosphorylation of the CDK's T-loop.
Shupp, Alison +2 more
openaire +4 more sources
CDK5 activator p35 downregulates E‐cadherin precursor independently of CDK5 [PDF]
FEBS Letters, 2008 Dysfunction of E-cadherins often results in metastasis of cancerous cells. Here we show that p35, a critical regulator of cyclin-dependent kinase 5 (CDK5), specifically depletes the precursor form of E-cadherin, but not the mature form, by using a precursor-specific antibody.
Lin, Shuyong +4 more
core +5 more sources
The role of Cdk5 in neurological disorders [PDF]
Frontiers in Cellular Neuroscience, 2022 Neurological disorders are a group of disorders with motor, sensory or cognitive damage, caused by dysfunction of the central or peripheral nervous system. Cyclin-dependent kinases 5 (Cdk5) is of vital significance for the development of the nervous system, including the migration and differentiation of neurons, the formation of synapses, and axon ...
Chuncao Ao +6 more
openaire +4 more sources